Detailed information NTG0336635

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: EQH46_RS10775
• Genome accession: NZ_CP035234
• Coordinates: 2103144..2103896 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain TVO_1902277
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2098144..2108896

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH46_RS11045 (EQH46_11275)	-	2100582..2102231 (-)	1650	Protein_2109	YhgE/Pip family protein	-
EQH46_RS10760 (EQH46_11280)	-	2102359..2102901 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
EQH46_RS10775 (EQH46_11295)	comE	2103144..2103896 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
EQH46_RS10780 (EQH46_11300)	comD	2103893..2105220 (-)	1328	Protein_2112	competence system sensor histidine kinase ComD	-
EQH46_RS10785 (EQH46_11305)	comC/comC1	2105241..2105366 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
EQH46_RS10795 (EQH46_11315)	rlmH	2105649..2106128 (-)	480	WP_000695930.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EQH46_RS10800 (EQH46_11320)	htrA	2106311..2107492 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
EQH46_RS10805 (EQH46_11325)	spo0J	2107550..2108308 (+)	759	WP_000410380.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=336635 EQH46_RS10775 WP_000866065.1 2103144..2103896(-) (comE) [Streptococcus pneumoniae strain TVO_1902277]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=336635 EQH46_RS10775 WP_000866065.1 2103144..2103896(-) (comE) [Streptococcus pneumoniae strain TVO_1902277]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408