Detailed information NTG0336627

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: EQH46_RS10025
• Genome accession: NZ_CP035234
• Coordinates: 1946586..1947293 (+)
• Length: 235 a.a.
• NCBI ID: WP_000166475.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain TVO_1902277
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	1945492..1945806	1946586..1947293	flank	780

Gene organization within MGE regions

Location: 1945492..1947293

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH46_RS10015 (EQH46_10530)	-	1945492..1946031 (-)	540	Protein_1963	transposase family protein	-
EQH46_RS10020 (EQH46_10535)	-	1946017..1946502 (+)	486	WP_001826677.1	cupin domain-containing protein	-
EQH46_RS10025 (EQH46_10540)	vicR	1946586..1947293 (+)	708	WP_000166475.1	response regulator transcription factor	Regulator

Sequence

Protein

• Length: 235 a.a.
• Molecular weight: 27230.61 Da
• Isoelectric Point: 6.6568

>NTDB_id=336627 EQH46_RS10025 WP_000166475.1 1946586..1947293(+) (vicR) [Streptococcus pneumoniae strain TVO_1902277]
MTKQVLLVDDEEHILKLLDYHLSKEGFSTQLVTNGRKALALAETEPFDFILLDIMLPQLDGMEVCKRLRAKGVKTPIMMV
SAKSDEFDKVLALELGADDYLTKPFSPRELLARVKAVLRRTKGEQEGDDSDNIADDSWLFGTLKVYPERHEVYKANKLLS
LTPKEFELLLYLMKHPNMTLTRERLLERIWGYDFGQETRLVDVHIGKLREKIEDNPKAPQFIRTIRGYGYKFKEL

Nucleotide

• Length: 708 bp

>NTDB_id=336627 EQH46_RS10025 WP_000166475.1 1946586..1947293(+) (vicR) [Streptococcus pneumoniae strain TVO_1902277]
ATGACAAAACAAGTCTTATTAGTGGATGATGAAGAACACATTCTGAAATTGCTTGACTACCATTTAAGTAAGGAAGGCTT
TTCTACTCAATTGGTAACAAATGGACGGAAGGCCTTAGCTTTGGCAGAAACAGAACCCTTTGATTTTATCTTGCTTGATA
TCATGTTACCACAATTAGATGGCATGGAAGTTTGTAAGCGGCTGAGAGCCAAAGGCGTCAAAACTCCAATTATGATGGTT
TCTGCGAAAAGTGATGAATTTGATAAGGTTTTGGCCTTGGAATTAGGGGCTGATGACTACCTGACCAAGCCTTTTAGCCC
TAGAGAATTGCTGGCGCGTGTCAAGGCTGTCCTCAGGCGAACTAAAGGAGAACAAGAAGGAGATGATTCAGATAATATCG
CTGACGATTCTTGGCTATTTGGGACCTTGAAAGTATACCCTGAGCGTCATGAAGTCTACAAGGCGAATAAGTTACTGAGT
TTGACCCCAAAAGAATTTGAACTCTTGCTCTATCTTATGAAACATCCCAACATGACACTGACTAGAGAGCGTCTTTTGGA
ACGTATCTGGGGGTATGACTTTGGGCAGGAAACACGTTTGGTGGACGTTCATATTGGTAAGTTGAGGGAAAAAATTGAAG
ACAATCCTAAAGCCCCTCAATTTATTCGAACCATTCGGGGTTATGGTTATAAGTTCAAGGAGTTATAG

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (159-232)

• Response regulator receiver domain (Response_reg) (5-115)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	48.707	98.723	0.481
micA	Streptococcus pneumoniae Cp1015	47.845	98.723	0.472
covR	Lactococcus lactis subsp. lactis strain DGCC12653	40.773	99.149	0.404
covR	Streptococcus salivarius strain HSISS4	39.744	99.574	0.396