Detailed information NTG0335161

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: EQI48_RS00575
• Genome accession: NZ_CP035164
• Coordinates: 103089..105521 (+)
• Length: 810 a.a.
• NCBI ID: WP_003235011.1
• Uniprot ID: P37571
• Organism: Bacillus subtilis strain SRCM104005
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 98089..110521

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQI48_RS00560 (EQI48_00560)	ctsR	100966..101430 (+)	465	WP_003225724.1	transcriptional regulator CtsR	-
EQI48_RS00565 (EQI48_00565)	mcsA	101444..102001 (+)	558	WP_015252993.1	protein-arginine kinase activator protein McsA	-
EQI48_RS00570 (EQI48_00570)	mcsB	102001..103092 (+)	1092	WP_003235007.1	protein arginine kinase	-
EQI48_RS00575 (EQI48_00575)	clpC	103089..105521 (+)	2433	WP_003235011.1	ATP-dependent protease ATP-binding subunit ClpC	Regulator
EQI48_RS00580 (EQI48_00580)	radA	105613..106989 (+)	1377	WP_029727024.1	DNA repair protein RadA	Machinery gene
EQI48_RS00585 (EQI48_00585)	disA	106993..108075 (+)	1083	WP_003225736.1	DNA integrity scanning diadenylate cyclase DisA	-
EQI48_RS00590 (EQI48_00590)	yacL	108191..109291 (+)	1101	WP_003235014.1	PIN/TRAM domain-containing protein	-
EQI48_RS00595 (EQI48_00595)	ispD	109306..110004 (+)	699	WP_046664350.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-
EQI48_RS00600 (EQI48_00600)	ispF	109997..110473 (+)	477	WP_003225745.1	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	-

Sequence

Protein

• Length: 810 a.a.
• Molecular weight: 90118.60 Da
• Isoelectric Point: 6.0257

>NTDB_id=335161 EQI48_RS00575 WP_003235011.1 103089..105521(+) (clpC) [Bacillus subtilis strain SRCM104005]
MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEGIAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHY
TPRAKKVIELSMDEARKLGHSYVGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT
PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIINNEVPEILRDKRVM
TLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIILFIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEY
RKYIEKDAALERRFQPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAIDLIDEAGS
KVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLREQVEDTKKSWKEKQGQENSEVTVDDIAMVV
SSWTGVPVSKIAQTETDKLLNMENILHSRVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAE
SIFGDEESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHPDVFNILLQVLEDGRLT
DSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNHKDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLT
EIVSLMSDQLTKRLKEQDLSIELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVEDGE
FVVKTTAKTN

Nucleotide

• Length: 2433 bp

>NTDB_id=335161 EQI48_RS00575 WP_003235011.1 103089..105521(+) (clpC) [Bacillus subtilis strain SRCM104005]
ATGATGTTTGGAAGATTTACAGAACGAGCTCAAAAAGTACTGGCGCTAGCACAGGAAGAAGCACTTCGGTTAGGTCATAA
TAACATTGGCACTGAGCATATTTTATTAGGACTGGTAAGAGAAGGAGAGGGCATTGCTGCTAAAGCTCTTCAAGCGCTTG
GACTCGGTTCAGAAAAAATTCAGAAAGAAGTAGAAAGTTTGATCGGGCGCGGGCAGGAAATGTCTCAAACGATTCATTAT
ACTCCTAGAGCTAAAAAAGTCATTGAGCTTTCAATGGATGAGGCAAGAAAACTCGGTCATTCTTATGTTGGAACAGAACA
TATTCTTCTTGGTCTGATTCGTGAAGGAGAAGGTGTTGCTGCGAGAGTTCTGAATAATCTCGGTGTCAGCTTAAATAAAG
CAAGACAGCAGGTGCTCCAGCTTCTAGGAAGTAATGAAACAGGATCATCAGCGGCAGGAACAAACAGCAATGCGAATACG
CCTACGCTCGACAGCTTGGCAAGAGACTTAACTGCTATTGCGAAGGAAGACAGCCTTGATCCTGTAATCGGCAGAAGCAA
GGAGATCCAGCGTGTCATTGAAGTGTTAAGCCGCAGAACGAAAAACAACCCTGTTCTCATTGGGGAACCAGGTGTAGGTA
AAACGGCTATCGCAGAAGGTTTGGCACAGCAAATTATCAATAATGAAGTGCCCGAAATTTTGCGTGATAAACGTGTGATG
ACATTAGACATGGGAACAGTTGTTGCCGGCACAAAATACCGCGGAGAATTTGAGGATCGCCTGAAGAAGGTCATGGATGA
AATTCGCCAGGCAGGAAATATCATTCTATTCATCGATGAGCTCCATACATTAATCGGGGCAGGCGGAGCAGAAGGTGCTA
TTGATGCATCTAATATTTTAAAACCTTCACTTGCTCGCGGTGAACTCCAATGTATTGGTGCAACGACTCTTGATGAGTAC
CGTAAATATATTGAAAAAGATGCAGCACTGGAACGCCGTTTTCAGCCGATTCAGGTTGATCAGCCATCTGTAGATGAAAG
TATTCAAATTTTACAAGGTCTGCGTGACAGATACGAAGCCCACCACCGCGTTTCTATCACTGATGATGCCATTGAAGCTG
CGGTTAAGCTTTCTGACAGATATATTTCTGACCGCTTCCTTCCGGATAAAGCAATTGACTTGATCGATGAAGCAGGTTCA
AAGGTGAGACTGCGCTCATTTACAACGCCTCCTAACTTAAAAGAGCTTGAGCAGAAGCTTGATGAGGTTCGTAAAGAGAA
GGATGCGGCAGTGCAAAGCCAAGAGTTTGAAAAAGCTGCTTCCTTGCGTGATACTGAACAACGCCTGCGCGAGCAAGTAG
AGGATACGAAGAAATCATGGAAAGAGAAGCAAGGGCAGGAAAACTCAGAGGTTACTGTGGATGATATTGCGATGGTTGTA
TCCAGCTGGACCGGTGTGCCTGTATCTAAAATCGCCCAAACTGAAACTGATAAGCTTCTCAATATGGAAAACATTCTTCA
TTCCCGCGTCATCGGCCAGGATGAGGCAGTTGTAGCTGTTGCAAAAGCCGTCAGACGTGCGAGAGCAGGGTTGAAAGATC
CTAAACGCCCAATCGGCTCATTCATTTTCTTAGGCCCTACAGGTGTAGGTAAAACAGAACTTGCACGAGCACTTGCTGAA
TCCATTTTTGGCGATGAAGAATCCATGATCAGAATTGACATGTCTGAATACATGGAAAAACACTCAACTTCAAGACTTGT
TGGTTCACCTCCGGGATATGTGGGATATGATGAAGGCGGTCAATTGACAGAGAAAGTCAGAAGAAAACCTTACTCTGTCG
TGCTTCTTGATGAGATCGAGAAAGCGCACCCTGATGTCTTCAATATCCTTCTGCAAGTTCTTGAAGACGGGCGATTGACT
GATTCTAAAGGACGCACAGTCGATTTCCGCAATACCATTCTGATCATGACATCAAACGTCGGAGCAAGTGAGCTGAAACG
CAATAAATATGTCGGCTTTAACGTTCAGGATGAAACTCAAAATCATAAAGACATGAAAGATAAAGTGATGGGTGAATTGA
AACGAGCGTTCAGACCTGAGTTCATCAACCGTATTGATGAAATCATTGTCTTCCATTCACTTGAGAAAAAACATCTTACT
GAAATTGTGTCATTAATGTCTGATCAATTAACGAAACGCCTGAAAGAACAAGATCTTTCTATCGAATTGACAGATGCTGC
AAAAGCGAAAGTCGCGGAAGAGGGCGTTGACCTGGAATACGGTGCCCGTCCGTTAAGAAGAGCGATCCAAAAACATGTCG
AGGATCGTTTATCTGAAGAACTCCTCAGAGGAAATATTCATAAAGGACAGCATATTGTTCTTGATGTAGAAGATGGCGAA
TTTGTCGTAAAAACGACTGCTAAAACGAATTAA

Domains

Predicted by InterproScan.

• Clp amino terminal domain, pathogenicity island component (Clp_N) (93-143)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (17-69)

• AAA lid domain (AAA_lid_9) (343-444)

• ATPase family associated with various cellular activities (AAA) (AAA) (205-317)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (714-793)

• AAA domain (Cdc48 subfamily) (AAA_2) (536-708)

3D structure

• PDB: 2K77
• PDB: 2Y1Q
• PDB: 2Y1R
• PDB: 3J3R
• PDB: 3J3S
• PDB: 3J3T
• PDB: 3J3U
• PDB: 3PXG
• PDB: 3PXI
• PDB: 5HBN
• PDB: 7ABR
• PDB: 8B3S
• PDB: 8OTK

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	100	100	1
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	50.499	99.012	0.5
clpC	Streptococcus thermophilus LMD-9	46.65	100	0.473
clpC	Streptococcus thermophilus LMG 18311	46.407	100	0.47
clpC	Streptococcus pneumoniae Rx1	45.241	99.877	0.452
clpC	Streptococcus pneumoniae D39	45.241	99.877	0.452
clpC	Streptococcus pneumoniae TIGR4	45.117	99.877	0.451
clpC	Streptococcus mutans UA159	43.584	100	0.444
clpE	Streptococcus mutans UA159	53.313	80.123	0.427
clpC	Lactococcus lactis subsp. cremoris KW2	48.664	87.778	0.427
clpE	Streptococcus pneumoniae TIGR4	52.388	80.123	0.42
clpE	Streptococcus pneumoniae Rx1	52.388	80.123	0.42
clpE	Streptococcus pneumoniae D39	52.388	80.123	0.42
clpE	Streptococcus pneumoniae R6	52.388	80.123	0.42