Detailed information NTG0033473

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: SZO_RS05495
• Genome accession: NC_012470
• Coordinates: 1159030..1159704 (-)
• Length: 224 a.a.
• NCBI ID: WP_012515548.1
• Uniprot ID: B4U2R0
• Organism: Streptococcus equi subsp. zooepidemicus
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1154030..1164704

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SZO_RS05450 (SZO_10360)	-	1154125..1154538 (-)	414	WP_041790454.1	hypothetical protein	-
SZO_RS05455 (SZO_10370)	-	1154554..1154814 (-)	261	WP_012678010.1	hypothetical protein	-
SZO_RS05460 (SZO_10380)	-	1154811..1155194 (-)	384	WP_041790456.1	hypothetical protein	-
SZO_RS05465 (SZO_10390)	-	1155367..1155618 (-)	252	WP_012678012.1	hypothetical protein	-
SZO_RS05470 (SZO_10400)	-	1155620..1156003 (-)	384	WP_012678013.1	hypothetical protein	-
SZO_RS05475	-	1155927..1156217 (-)	291	WP_021320713.1	hypothetical protein	-
SZO_RS05480 (SZO_10420)	-	1156227..1156634 (-)	408	WP_014622815.1	hypothetical protein	-
SZO_RS10635 (SZO_10430)	-	1156650..1156826 (-)	177	WP_014622814.1	hypothetical protein	-
SZO_RS05485 (SZO_10440)	-	1156908..1157342 (-)	435	WP_012678015.1	hypothetical protein	-
SZO_RS05490 (SZO_10450)	ciaH	1157727..1159037 (-)	1311	WP_012515549.1	sensor histidine kinase	Regulator
SZO_RS05495 (SZO_10460)	ciaR	1159030..1159704 (-)	675	WP_012515548.1	response regulator transcription factor	Regulator
SZO_RS05500 (SZO_10470)	-	1160123..1162660 (-)	2538	WP_012678017.1	M1 family metallopeptidase	-
SZO_RS05505 (SZO_10480)	phoU	1162894..1163547 (-)	654	WP_012678018.1	phosphate signaling complex protein PhoU	-
SZO_RS05510 (SZO_10490)	pstB	1163618..1164376 (-)	759	WP_012678019.1	phosphate ABC transporter ATP-binding protein PstB	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25541.52 Da
• Isoelectric Point: 4.5644

>NTDB_id=33473 SZO_RS05495 WP_012515548.1 1159030..1159704(-) (ciaR) [Streptococcus equi subsp. zooepidemicus]
MIKLLLVEDDLSLSNSIFDFLDDFADVTQVFDGDEGLYEAESGIYDLILLDLMLPEKDGFQVLKALREKDIKIPVLIMTA
KESIDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRVGKFNDKSLKFGNLTVDTTRKEVQVNGQAIELLGKELDLLIY
ILQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTDFVNHLQTLRSVGYILKANE

Nucleotide

• Length: 675 bp

>NTDB_id=33473 SZO_RS05495 WP_012515548.1 1159030..1159704(-) (ciaR) [Streptococcus equi subsp. zooepidemicus]
ATGATAAAACTATTATTAGTAGAAGACGATTTAAGCTTGTCAAATTCTATCTTTGATTTTTTAGATGACTTTGCTGATGT
GACGCAGGTTTTTGATGGTGACGAAGGACTCTATGAGGCAGAAAGCGGTATTTATGATTTGATTCTGTTAGATTTGATGC
TGCCTGAAAAGGATGGCTTTCAAGTGTTAAAAGCCTTACGTGAAAAAGACATCAAAATTCCCGTCTTGATCATGACTGCC
AAAGAAAGCATCGATGACAAGGGGCATGGCTTTGAGCTTGGTGCTGATGACTATTTAACTAAGCCCTTTTACCTAGAAGA
ATTAAAAATGCGGATTCAGGCCTTGCTTAAGCGTGTAGGAAAGTTTAATGATAAGAGCCTTAAATTTGGCAACTTGACTG
TAGATACTACCCGTAAAGAGGTACAGGTCAATGGGCAGGCCATAGAGCTATTAGGCAAGGAGCTTGATTTACTAATCTAT
ATCCTTCAAAATCAAAATGTTATTTTGCCAAAATCACAAATTTTTGATCGTATCTGGGGCTTTGATAGTGATACCACTAT
CTCTGTTGTAGAGGTCTATGTCTCTAAAATTCGTAAGAAGCTTAAGGGGACAGACTTTGTTAATCATCTTCAAACCTTGA
GAAGTGTAGGATATATCTTAAAAGCTAATGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (5-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: B4U2R0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	84.615	98.661	0.835
ciaR	Streptococcus pneumoniae Rx1	80.543	98.661	0.795
ciaR	Streptococcus pneumoniae D39	80.543	98.661	0.795
ciaR	Streptococcus pneumoniae R6	80.543	98.661	0.795
ciaR	Streptococcus pneumoniae TIGR4	80.543	98.661	0.795
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.428	100	0.393
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.362