Detailed information NTG0033471

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SZO_RS05275
• Genome accession: NC_012470
• Coordinates: 1117268..1118005 (-)
• Length: 245 a.a.
• NCBI ID: WP_012515591.1
• Uniprot ID: B4U2V5
• Organism: Streptococcus equi subsp. zooepidemicus
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1112268..1123005

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SZO_RS05250 (SZO_09950)	-	1112469..1113320 (-)	852	WP_012515597.1	thioredoxin family protein	-
SZO_RS05255 (SZO_09952)	-	1114113..1114343 (-)	231	WP_012515596.1	Blp family class II bacteriocin	-
SZO_RS05260 (SZO_09960)	-	1114605..1115768 (-)	1164	WP_012677980.1	ABC transporter permease subunit	-
SZO_RS05265 (SZO_09970)	-	1115774..1116628 (-)	855	WP_012515593.1	ABC transporter ATP-binding protein	-
SZO_RS05270 (SZO_09980)	-	1116695..1116895 (-)	201	WP_012515592.1	hypothetical protein	-
SZO_RS05275 (SZO_09990)	comE/blpR	1117268..1118005 (-)	738	WP_012515591.1	response regulator transcription factor	Regulator
SZO_RS05280 (SZO_10000)	-	1118772..1119077 (-)	306	WP_012677981.1	AraC family ligand binding domain-containing protein	-
SZO_RS05285 (SZO_10010)	-	1119079..1119417 (-)	339	WP_012677982.1	cupin domain-containing protein	-
SZO_RS05290 (SZO_10020)	-	1119445..1120200 (-)	756	WP_041790440.1	class I SAM-dependent methyltransferase	-
SZO_RS05295 (SZO_10030)	-	1120460..1120915 (+)	456	WP_012677984.1	DUF1836 domain-containing protein	-
SZO_RS05300 (SZO_10040)	trhA	1120899..1121549 (+)	651	WP_012677985.1	PAQR family membrane homeostasis protein TrhA	-
SZO_RS05305 (SZO_10050)	-	1121660..1122565 (+)	906	WP_012677986.1	diacylglycerol/lipid kinase family protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28894.28 Da
• Isoelectric Point: 7.8796

>NTDB_id=33471 SZO_RS05275 WP_012515591.1 1117268..1118005(-) (comE/blpR) [Streptococcus equi subsp. zooepidemicus]
MNIFILEDDLGQQFRLEMKIQEILDKHHWTCDRFEVYGKPYQLLANVTERGRHQLFFLDSQIRNDEKKGLAVAREIRKRD
PYALIVFVTTHSELMPVSFRYQVSALDFIDKELSMKHFSDRIERAIIYAYEEQENVTSEGLFIFVTAKAQVQVPFSSLLF
IETSSTPHKLILHSQNERIEFYGFLSEVLKQDSRLVQCHRSYVINPYNVSFLDRDKRLLYFKNGQSCMVSRLKMKALEAS
IKALH

Nucleotide

• Length: 738 bp

>NTDB_id=33471 SZO_RS05275 WP_012515591.1 1117268..1118005(-) (comE/blpR) [Streptococcus equi subsp. zooepidemicus]
ATGAATATTTTTATTCTCGAAGATGATCTAGGCCAACAGTTTAGGCTTGAGATGAAGATTCAAGAGATATTGGATAAGCA
TCACTGGACTTGTGATCGTTTTGAAGTTTATGGAAAGCCCTACCAGCTTCTGGCAAATGTTACAGAGAGAGGCAGGCATC
AGCTTTTCTTTCTCGATAGTCAAATTCGAAATGATGAGAAAAAGGGCTTAGCTGTTGCTCGTGAGATCAGAAAGCGTGAC
CCTTATGCCCTTATTGTTTTTGTCACCACACATTCTGAGCTTATGCCAGTTTCTTTTCGTTATCAGGTGTCTGCTCTAGA
TTTTATTGATAAGGAATTGTCAATGAAACATTTCTCAGATAGGATTGAAAGAGCCATTATATATGCTTATGAAGAGCAAG
AAAATGTAACCTCAGAGGGCTTATTTATTTTTGTAACGGCTAAGGCTCAGGTGCAGGTTCCTTTTTCAAGCCTATTGTTC
ATTGAGACCTCTAGTACTCCTCACAAGTTGATTTTGCATTCTCAAAACGAGCGAATAGAATTTTATGGCTTTCTTTCAGA
GGTTCTTAAGCAAGATTCCAGACTAGTCCAATGTCATCGTTCTTATGTTATCAATCCTTACAATGTTTCGTTTCTTGATC
GTGATAAGCGTTTACTCTATTTCAAGAATGGGCAGTCTTGCATGGTTTCAAGACTAAAAATGAAAGCACTTGAGGCGTCT
ATTAAGGCTTTGCATTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-240)

• Response regulator receiver domain (Response_reg) (18-122)

3D structure

• AlphaFold DB: B4U2V5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.719	98.776	0.531
comE/comE1	Streptococcus equinus JB1	45.455	98.776	0.449
comE/comE2	Streptococcus equinus JB1	36.885	99.592	0.367