Detailed information NTG0333915

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: EMO94_RS01670
• Genome accession: NZ_CP035005
• Coordinates: 311474..312517 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain PCFH-226
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 306474..317517

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EMO94_RS01635	-	307089..307199 (+)	111	WP_014937049.1	hypothetical protein	-
EMO94_RS01640	-	307228..307641 (+)	414	WP_025174370.1	hypothetical protein	-
EMO94_RS01645	-	307830..308816 (-)	987	WP_000999712.1	aromatic acid exporter family protein	-
EMO94_RS01655	map	309400..310158 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
EMO94_RS01660	-	310375..310761 (+)	387	WP_001110182.1	hypothetical protein	-
EMO94_RS01665	liaF	310776..311477 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
EMO94_RS01670	vraS	311474..312517 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
EMO94_RS01675	vraR	312507..313136 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
EMO94_RS01680	-	313249..314466 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
EMO94_RS01685	-	314744..315019 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
EMO94_RS01690	-	315026..315490 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
EMO94_RS01695	-	315637..315837 (+)	201	WP_000180460.1	DUF1128 family protein	-
EMO94_RS01700	-	315840..317096 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=333915 EMO94_RS01670 WP_001017131.1 311474..312517(+) (vraS) [Staphylococcus aureus strain PCFH-226]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=333915 EMO94_RS01670 WP_001017131.1 311474..312517(+) (vraS) [Staphylococcus aureus strain PCFH-226]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1