Detailed information NTG0032916

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: SUB_RS02605
• Genome accession: NC_012004
• Coordinates: 479631..481784 (-)
• Length: 717 a.a.
• NCBI ID: WP_012658032.1
• Uniprot ID: A0A6L6GAR2
• Organism: Streptococcus uberis 0140J
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 474631..486784

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SUB_RS02580 (SUB0495)	-	474906..475697 (+)	792	WP_012658026.1	hypothetical protein	-
SUB_RS02590 (SUB0497)	-	476300..476929 (+)	630	WP_012658028.1	ATP-binding cassette domain-containing protein	-
SUB_RS09805	-	476975..477114 (+)	140	Protein_477	DNA mismatch repair protein MutT	-
SUB_RS02595 (SUB0498)	-	477357..478097 (+)	741	WP_012658029.1	LytR/AlgR family response regulator transcription factor	-
SUB_RS02600 (SUB0499)	-	478624..479439 (+)	816	WP_170123120.1	sensor histidine kinase	-
SUB_RS09810	-	479449..479595 (-)	147	WP_080502297.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
SUB_RS02605 (SUB0501)	comA/nlmT	479631..481784 (-)	2154	WP_012658032.1	peptide cleavage/export ABC transporter	Regulator
SUB_RS02610 (SUB0502)	-	482015..482248 (+)	234	Protein_482	ComC/BlpC family peptide pheromone/bacteriocin	-
SUB_RS02615 (SUB0505)	-	482867..483091 (+)	225	WP_046388584.1	Blp family class II bacteriocin	-
SUB_RS02620 (SUB0506)	-	483102..483302 (+)	201	WP_012658034.1	hypothetical protein	-
SUB_RS02630 (SUB0509)	-	483979..484224 (+)	246	WP_012658036.1	garvicin Q family class II bacteriocin	-
SUB_RS02635 (SUB0510)	-	484227..484526 (+)	300	WP_012658037.1	bacteriocin immunity protein	-
SUB_RS02640	-	484915..485130 (+)	216	WP_154590649.1	hypothetical protein	-
SUB_RS02645 (SUB0512)	-	485369..485596 (+)	228	WP_012658038.1	bacteriocin	-
SUB_RS09305 (SUB0513)	-	485672..485992 (+)	321	WP_052718489.1	bacteriocin immunity protein	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 81505.49 Da
• Isoelectric Point: 9.8184

>NTDB_id=32916 SUB_RS02605 WP_012658032.1 479631..481784(-) (comA/nlmT) [Streptococcus uberis 0140J]
MFYYYKSYTSQVDENDCGVAALASIAKYYGSHYSISYFRQLANTTREGTTALGIINAANALGFKTKAIKADISLFDIKNL
DFPLIVHVIKNNELAHYYIVYKSYRNHLLIGDPDPSVKIVKMAKDKFAEEWTGVALLFKPSRNYSPTNQNFFSPVSYTKV
ISKRLTLIFLITIISLIITLISILSSYYLQATIDFYIPNKMFSALEIITFGLISTFILQEILTYFRDYLLILLNQKLSID
IILAYIQHLFKLPLSFFSTRRTGEITSRFNDANSIIDAIASTILTIFLDFLMTICVGMTLFFQNKILFTITLVGIPIYTI
LILSFYKSFKKMNQELMQANALVSSTIIEDLNGIETIKALSCEEKSFKRINDEFREVLQKSFRLQKLTVLQSALKKGTQQ
ILNVIILWVGAKLVISGKISIGQLITFNALLVYFTTPIENIINLQNKIQSAKEANNRLNEVYYEKSEFENNQNTKLKIDK
LRTIDLKNISFKYGIGHDLLKNINLTIREGEKICIIGTSGSGKTTLAKLIVGFQKPTEGKITINNYDMDKINKKTIRYFI
NYLPQQPYLFTGTIIENLTFGIYKDISQEKIEEACRIAAILGDIEKMPLKFNTKFSDGFGLSGGQKQRIALVRALLSDSP
ILILDEATSGLDIQTEKLIINNLLKLKNKTIIFIAHRLAIAEKTDRIIVMNRGKISEMGSHKELISRKGAYYQLLNS

Nucleotide

• Length: 2154 bp

>NTDB_id=32916 SUB_RS02605 WP_012658032.1 479631..481784(-) (comA/nlmT) [Streptococcus uberis 0140J]
ATGTTCTACTATTACAAAAGCTATACTTCACAAGTTGACGAAAATGATTGTGGAGTGGCGGCATTAGCTTCTATTGCAAA
ATATTATGGATCACATTATTCTATTAGCTATTTTCGACAATTAGCTAATACTACACGCGAAGGAACTACAGCTCTTGGAA
TAATAAATGCAGCAAACGCACTTGGTTTCAAAACAAAAGCTATTAAAGCGGATATATCACTTTTTGACATTAAAAATTTG
GATTTTCCATTAATTGTTCATGTCATTAAAAATAATGAATTGGCACATTACTATATTGTTTATAAATCATATAGAAATCA
CCTCCTCATTGGAGATCCTGATCCCTCAGTTAAAATCGTAAAAATGGCAAAGGATAAGTTTGCTGAGGAATGGACTGGGG
TTGCCCTACTTTTTAAACCTAGTCGAAATTACTCTCCTACAAATCAAAATTTTTTCTCTCCTGTATCATATACAAAAGTC
ATTAGTAAGCGTCTTACACTGATTTTTCTGATAACAATAATTAGTTTAATAATTACTCTTATAAGTATATTATCTTCCTA
TTACCTACAAGCCACGATAGATTTCTACATTCCGAATAAAATGTTTTCTGCTTTAGAAATCATCACATTCGGATTAATTA
GCACTTTCATTCTTCAAGAAATATTAACTTATTTTCGAGATTACCTACTTATCCTATTAAATCAAAAACTAAGTATTGAT
ATAATATTAGCCTATATTCAACATCTTTTTAAATTACCTTTATCCTTTTTTTCAACTAGGCGAACTGGAGAAATAACCTC
TAGATTTAATGATGCTAATTCTATTATAGATGCCATAGCATCAACTATATTAACGATTTTTCTGGATTTTTTGATGACAA
TTTGTGTCGGAATGACACTCTTTTTTCAAAATAAAATATTATTTACTATTACTTTAGTTGGAATTCCAATTTATACCATA
CTCATATTATCTTTTTATAAATCATTTAAGAAAATGAATCAAGAATTAATGCAAGCAAATGCATTGGTTAGTTCAACAAT
TATTGAAGATTTAAATGGTATAGAAACTATCAAAGCCCTATCTTGTGAAGAAAAAAGTTTTAAAAGAATTAATGATGAAT
TTAGAGAGGTCCTACAAAAATCATTTCGTTTACAAAAATTAACAGTACTTCAGAGTGCTTTAAAAAAAGGTACCCAACAA
ATATTAAATGTTATTATTTTGTGGGTTGGAGCAAAATTGGTTATCTCTGGAAAAATTTCAATTGGACAGTTAATTACTTT
CAATGCACTACTTGTTTACTTCACTACTCCTATTGAAAATATAATAAATTTACAAAATAAGATACAATCTGCAAAAGAAG
CAAATAACAGACTTAATGAAGTATATTATGAGAAATCAGAATTCGAAAATAATCAGAATACAAAATTAAAAATTGATAAA
CTTCGTACCATAGATTTAAAAAATATCTCCTTTAAATATGGGATTGGTCACGATCTCTTGAAAAATATTAATTTAACAAT
TAGGGAGGGAGAAAAAATTTGTATAATTGGAACTAGCGGCTCTGGAAAAACGACACTTGCAAAGTTGATTGTTGGTTTCC
AAAAACCAACTGAAGGTAAAATAACTATTAATAATTATGATATGGATAAGATTAATAAAAAAACAATCCGATATTTTATT
AACTATTTACCACAGCAACCCTATTTATTTACAGGGACGATAATAGAAAATTTGACATTTGGTATCTATAAAGATATCTC
TCAAGAAAAAATTGAGGAAGCTTGTCGAATTGCTGCAATACTAGGAGATATAGAGAAAATGCCACTCAAATTTAATACCA
AATTCAGTGATGGATTTGGCCTTTCTGGAGGACAAAAGCAAAGAATCGCTTTAGTTAGGGCATTGTTAAGTGATTCTCCC
ATTCTCATATTAGATGAAGCAACGAGTGGATTGGATATTCAAACAGAAAAATTGATTATAAATAATCTCTTGAAATTAAA
AAATAAAACCATTATTTTTATAGCACATCGATTAGCTATCGCTGAGAAAACTGATCGAATTATTGTAATGAATAGAGGTA
AAATTTCTGAAATGGGAAGTCATAAAGAATTAATTTCAAGAAAAGGTGCCTACTATCAATTATTAAATTCTTAA

Domains

Predicted by InterproScan.

• ABC transporter transmembrane region (ABC_membrane) (168-437)

• ABC transporter (ABC_tran) (500-649)

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: A0A6L6GAR2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	55.634	99.024	0.551
comA	Streptococcus mitis NCTC 12261	52.999	100	0.53
comA	Streptococcus mitis SK321	53.221	99.582	0.53
comA	Streptococcus pneumoniae D39	52.301	100	0.523
comA	Streptococcus pneumoniae Rx1	52.301	100	0.523
comA	Streptococcus pneumoniae R6	52.301	100	0.523
comA	Streptococcus gordonii str. Challis substr. CH1	51.95	100	0.52
comA	Streptococcus pneumoniae TIGR4	52.022	100	0.52