Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   EH163_RS03820 Genome accession   NZ_CP034115
Coordinates   728376..729743 (+) Length   455 a.a.
NCBI ID   WP_058649886.1    Uniprot ID   -
Organism   Staphylococcus epidermidis strain CDC121     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 677477..750436 728376..729743 within 0


Gene organization within MGE regions


Location: 677477..750436
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EH163_RS03540 mecA 677477..679486 (-) 2010 WP_063852638.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  EH163_RS03545 - 679583..679690 (+) 108 Protein_655 beta-lactam sensor/signal transducer MecR1 -
  EH163_RS03550 - 679731..680405 (+) 675 Protein_656 IS6 family transposase -
  EH163_RS03555 - 680465..680893 (-) 429 WP_000671996.1 VOC family protein -
  EH163_RS03560 - 680974..681903 (+) 930 WP_000750311.1 HTH domain-containing protein -
  EH163_RS03565 - 682065..682529 (+) 465 Protein_659 hypothetical protein -
  EH163_RS03570 - 682615..683756 (+) 1142 WP_089418807.1 IS3 family transposase -
  EH163_RS03575 - 683763..685328 (+) 1566 WP_021758024.1 DUF6038 family protein -
  EH163_RS03580 - 685523..686632 (+) 1110 WP_000283873.1 DNA polymerase -
  EH163_RS03585 - 686625..686996 (+) 372 WP_124726190.1 hypothetical protein -
  EH163_RS03590 - 686993..688612 (+) 1620 WP_044466479.1 DUF5906 domain-containing protein -
  EH163_RS03595 - 688838..690517 (+) 1680 WP_044466480.1 recombinase family protein -
  EH163_RS03600 - 690606..690944 (+) 339 WP_000175891.1 SAUGI family uracil-DNA glycosylase inhibitor -
  EH163_RS03610 - 691038..691349 (+) 312 WP_000700854.1 DUF960 domain-containing protein -
  EH163_RS03615 - 691364..691844 (+) 481 Protein_668 DUF1643 domain-containing protein -
  EH163_RS03620 - 691858..692079 (+) 222 WP_001015191.1 hypothetical protein -
  EH163_RS03625 - 692154..695273 (-) 3120 WP_124743116.1 type I restriction endonuclease subunit R -
  EH163_RS03630 - 695257..696504 (-) 1248 WP_058649891.1 restriction endonuclease subunit S -
  EH163_RS03635 - 696494..698008 (-) 1515 WP_049387566.1 class I SAM-dependent DNA methyltransferase -
  EH163_RS03640 - 698227..698712 (+) 486 WP_049387565.1 hypothetical protein -
  EH163_RS03645 - 698832..699056 (+) 225 Protein_674 YfcC family protein -
  EH163_RS03650 - 699375..699713 (-) 339 WP_124743117.1 hypothetical protein -
  EH163_RS03655 - 699717..700847 (-) 1131 Protein_676 IS3 family transposase -
  EH163_RS03660 - 700875..701390 (-) 516 WP_241157415.1 hypothetical protein -
  EH163_RS03670 - 702161..702372 (-) 212 Protein_678 hypothetical protein -
  EH163_RS03675 - 702644..703717 (+) 1074 WP_058649890.1 hypothetical protein -
  EH163_RS03680 - 703752..704500 (+) 749 Protein_680 hypothetical protein -
  EH163_RS03685 - 704517..705518 (+) 1002 WP_058649889.1 DUF1002 domain-containing protein -
  EH163_RS03690 - 705589..706278 (+) 690 WP_049387562.1 hypothetical protein -
  EH163_RS03700 - 707685..708116 (-) 432 WP_000475805.1 universal stress protein -
  EH163_RS03705 - 708705..709151 (+) 447 WP_000711814.1 ArgR family transcriptional regulator -
  EH163_RS03710 arcA 709420..710655 (+) 1236 WP_000249804.1 arginine deiminase -
  EH163_RS03715 arcD 710741..712162 (+) 1422 WP_000344142.1 arginine-ornithine antiporter -
  EH163_RS03720 - 712204..712893 (+) 690 WP_000272781.1 Crp/Fnr family transcriptional regulator -
  EH163_RS03725 argF 712931..713929 (+) 999 WP_000793596.1 ornithine carbamoyltransferase -
  EH163_RS03730 arcC 713949..714878 (+) 930 WP_002502213.1 carbamate kinase -
  EH163_RS03735 - 714978..715969 (-) 992 Protein_691 IS3 family transposase -
  EH163_RS03740 - 715956..716170 (+) 215 Protein_692 D-alanyl-D-alanine carboxypeptidase family protein -
  EH163_RS03745 - 716758..717108 (+) 351 WP_002502216.1 SAUGI family uracil-DNA glycosylase inhibitor -
  EH163_RS03755 - 717195..717506 (+) 312 WP_000700852.1 DUF960 family protein -
  EH163_RS03760 - 717521..718023 (+) 503 Protein_695 DUF1643 domain-containing protein -
  EH163_RS03765 - 718038..718259 (+) 222 WP_002502218.1 hypothetical protein -
  EH163_RS03770 - 718517..719644 (-) 1128 WP_058649888.1 zinc-dependent alcohol dehydrogenase family protein -
  EH163_RS13180 - 719826..719954 (+) 129 WP_001791888.1 hypothetical protein -
  EH163_RS03775 - 720142..720639 (+) 498 WP_000776433.1 GNAT family N-acetyltransferase -
  EH163_RS03780 - 721153..722003 (+) 851 Protein_700 IS3 family transposase -
  EH163_RS03790 - 722533..722892 (+) 360 WP_000432278.1 hypothetical protein -
  EH163_RS03795 - 722969..723298 (-) 330 WP_000124775.1 hypothetical protein -
  EH163_RS03800 - 723390..723581 (-) 192 WP_000291518.1 hypothetical protein -
  EH163_RS03805 - 723678..724643 (-) 966 WP_000027972.1 HNH endonuclease -
  EH163_RS12895 - 725045..725215 (+) 171 WP_001141152.1 hypothetical protein -
  EH163_RS03810 - 725424..725612 (+) 189 Protein_706 hypothetical protein -
  EH163_RS03815 - 725905..727725 (-) 1821 WP_058649887.1 AAA family ATPase -
  EH163_RS03820 ccrA 728376..729743 (+) 1368 WP_058649886.1 recombinase family protein Machinery gene
  EH163_RS03825 ccrB 729740..731365 (+) 1626 WP_058649885.1 recombinase family protein Machinery gene
  EH163_RS03830 - 731887..732237 (+) 351 WP_058649884.1 SAUGI family uracil-DNA glycosylase inhibitor -
  EH163_RS03835 - 732324..732635 (+) 312 WP_058649883.1 DUF960 domain-containing protein -
  EH163_RS03840 - 732650..733153 (+) 504 WP_124743118.1 DUF1643 domain-containing protein -
  EH163_RS03845 gtfB 733334..734653 (-) 1320 WP_001551922.1 accessory Sec system glycosylation chaperone GtfB -
  EH163_RS03850 gtfA 734646..736154 (-) 1509 WP_001551920.1 accessory Sec system glycosyltransferase GtfA -
  EH163_RS03855 - 736243..739476 (-) 3234 WP_124743119.1 SdrD B-like domain-containing protein -
  EH163_RS03860 - 739716..739949 (+) 234 WP_002467980.1 hypothetical protein -
  EH163_RS03865 - 740406..740573 (-) 168 WP_000669688.1 hypothetical protein -
  EH163_RS03870 - 741223..741435 (+) 213 WP_001257909.1 DUF1958 domain-containing protein -
  EH163_RS03875 - 741524..742942 (+) 1419 WP_032605060.1 aspartate aminotransferase family protein -
  EH163_RS03880 - 743010..743192 (-) 183 Protein_720 MFS transporter -
  EH163_RS03885 - 743402..745150 (-) 1749 WP_000585108.1 ATP-dependent helicase -
  EH163_RS03890 - 745152..747248 (-) 2097 WP_223200550.1 AAA family ATPase -
  EH163_RS03895 - 747657..749171 (+) 1515 WP_000190901.1 class I SAM-dependent DNA methyltransferase -
  EH163_RS13060 - 749161..749337 (+) 177 WP_241157416.1 hypothetical protein -
  EH163_RS03900 - 749327..750436 (+) 1110 WP_241157417.1 restriction endonuclease subunit S -

Sequence

Protein


Download         Length: 455 a.a.        Molecular weight: 53471.41 Da        Isoelectric Point: 9.8406

>NTDB_id=329146 EH163_RS03820 WP_058649886.1 728376..729743(+) (ccrA) [Staphylococcus epidermidis strain CDC121]
MVEAIGYVRQSTLKQQSLATQKSLIMETAKQYGWHNIEFYDDKKTGRHTKRSGYQRMVEAITSRKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHVTIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQVQNGIREKAKQGKLITTHAPFGYRYR
KGRFIVHKEEAYTVKIVYRWYLQGLGYKKISQKLDKDMNFISRKPYQVRNILMNPNYCGRVINKYGTFNDIVSPIIDVDT
FEEAQERRIHKQHNRSNSRNKLKRRIKCPYCQSTLTNLTIKKRNHSLRYYVCPKNMNDAYYTCSFKGMNAQTIEAEILDT
CKSYFKEQAHHSHLNERIIETLERQKMKHKQTQITQEELIEKLAQNHIDVETFKQLSTSNESETHCSSPTYLSNQMTKTI
SHISKGKLTLEDIAPLIGDITITQTKQLQGIYLKHSPINIVEQSHLIPCERNENL

Nucleotide


Download         Length: 1368 bp        

>NTDB_id=329146 EH163_RS03820 WP_058649886.1 728376..729743(+) (ccrA) [Staphylococcus epidermidis strain CDC121]
ATGGTAGAAGCCATTGGTTACGTACGTCAAAGTACATTAAAACAACAAAGTTTAGCTACTCAAAAGTCACTTATTATGGA
AACTGCAAAGCAATATGGTTGGCACAATATAGAATTTTATGACGATAAGAAAACAGGTCGACATACAAAACGTTCGGGTT
ATCAAAGGATGGTAGAAGCGATTACGTCCAGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAATCGACTTCATCGTAAT
TTGAAAAACGCTATACAATTCTTTGAAATTTGTAAAAAGCATCACGTCACAATCATCAGTGTAAACGATGGCTATTTTGA
TTTGTCTAAAGAATTTGATTGTTTTCGCTTGAACATACTCATGAGTCTAGCAGAAATGGAATCAAACAATATTAGTGAAC
AAGTACAAAATGGTATAAGAGAAAAAGCCAAACAAGGTAAGTTGATTACAACACATGCCCCTTTTGGCTATCGTTATAGA
AAAGGCCGCTTTATTGTACACAAAGAAGAAGCGTATACAGTTAAAATAGTTTATCGTTGGTATTTACAAGGCCTAGGTTA
TAAGAAAATTTCTCAAAAGCTGGATAAAGATATGAATTTTATTTCTCGTAAGCCCTACCAAGTTAGAAACATTCTCATGA
ATCCTAACTATTGTGGTCGTGTTATCAATAAGTATGGCACATTTAATGATATCGTTTCGCCTATTATTGATGTTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACACAATCGATCCAATTCTAGAAATAAGCTAAAACGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACTAACTTGACGATTAAAAAAAGGAATCATTCACTACGTTACTACGTTTGTCCTA
AGAATATGAATGATGCTTATTACACTTGTTCGTTTAAAGGTATGAATGCACAAACAATTGAAGCAGAAATTCTCGATACT
TGTAAATCATATTTTAAAGAACAAGCACATCACAGTCATCTAAATGAGAGAATAATTGAAACACTAGAACGTCAAAAAAT
GAAACACAAACAAACACAGATAACACAAGAAGAGCTTATCGAAAAACTAGCTCAAAATCATATTGATGTAGAAACATTTA
AACAACTATCTACTAGTAATGAGAGCGAAACACATTGCTCTTCCCCCACTTATTTATCTAATCAAATGACTAAGACAATC
AGTCATATATCTAAAGGTAAATTGACATTAGAAGATATAGCCCCTTTGATTGGTGACATTACAATAACTCAAACCAAACA
ATTACAAGGAATCTACTTGAAACATAGTCCAATCAATATCGTTGAACAATCTCACTTAATACCTTGTGAAAGGAATGAAA
ACTTATGA

Domains

Predicted by InterproScan.

Recombinase (Recombinase)

(168-248)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-322)

Resolvase, N terminal domain (Resolvase)

(4-147)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus COL

53.363

98.022

0.523
  ccrA Staphylococcus aureus N315

50.45

97.582

0.492

Multiple sequence alignment