Detailed information NTG0032709

Bioinformatically predicted

Overview

• Name: braR
• Type: Regulator
• Locus tag: HMPREF0837_RS08950
• Genome accession: NC_014251
• Coordinates: 1715195..1715872 (-)
• Length: 225 a.a.
• NCBI ID: WP_000548959.1
• Uniprot ID: Q9S1K2
• Organism: Streptococcus pneumoniae TCH8431/19A
• Function: promote expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1710195..1720872

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HMPREF0837_RS08920 (HMPREF0837_11866)	-	1710358..1710987 (-)	630	WP_000762091.1	NAD(P)-dependent oxidoreductase	-
HMPREF0837_RS08925 (HMPREF0837_11868)	-	1711225..1711425 (+)	201	WP_001814296.1	hypothetical protein	-
HMPREF0837_RS08930 (HMPREF0837_11869)	-	1711855..1711995 (+)	141	WP_000422775.1	MazG-like protein	-
HMPREF0837_RS08935 (HMPREF0837_11870)	-	1712002..1712178 (+)	177	WP_000166031.1	MazG-like protein	-
HMPREF0837_RS08940 (HMPREF0837_11871)	thrS	1712236..1714179 (+)	1944	WP_000608349.1	threonine--tRNA ligase	-
HMPREF0837_RS08945 (HMPREF0837_11872)	-	1714228..1715202 (-)	975	WP_000887953.1	HAMP domain-containing histidine kinase	-
HMPREF0837_RS08950 (HMPREF0837_11873)	braR	1715195..1715872 (-)	678	WP_000548959.1	response regulator transcription factor	Regulator
HMPREF0837_RS08955 (HMPREF0837_11874)	-	1716028..1717101 (+)	1074	WP_001273823.1	DUF2974 domain-containing protein	-
HMPREF0837_RS08960 (HMPREF0837_11875)	-	1717192..1717494 (-)	303	WP_000281609.1	hypothetical protein	-
HMPREF0837_RS08965 (HMPREF0837_11876)	-	1717562..1717999 (-)	438	WP_001166785.1	Rrf2 family transcriptional regulator	-
HMPREF0837_RS08970 (HMPREF0837_11877)	-	1718075..1718917 (-)	843	WP_000160938.1	metallophosphoesterase	-
HMPREF0837_RS08975 (HMPREF0837_11878)	-	1719029..1719679 (+)	651	WP_000188505.1	metal-dependent transcriptional regulator	-
HMPREF0837_RS13375 (HMPREF0837_11879)	-	1719660..1719851 (+)	192	WP_001816503.1	hypothetical protein	-
HMPREF0837_RS08985 (HMPREF0837_11880)	-	1719877..1720552 (+)	676	Protein_1714	nicotinamide mononucleotide transporter	-
HMPREF0837_RS13445	-	1720654..1720725 (+)	72	Protein_1715	glutamine ABC transporter permease	-

Sequence

Protein

• Length: 225 a.a.
• Molecular weight: 25964.16 Da
• Isoelectric Point: 5.1362

>NTDB_id=32709 HMPREF0837_RS08950 WP_000548959.1 1715195..1715872(-) (braR) [Streptococcus pneumoniae TCH8431/19A]
MHKILLIEDDQVIRQQIGKMLSEWGFEVVLVEDFMEVLSLFVQSEPHLVLMDIGLPLFNGYHWCQEIRKISKVPIMFLSS
RDQAMDIVMAINMGADDFVTKPFDQQVLLAKVQGLLRRSYEFGRDESLLEYAGVILNTKSMDLHYQGQVLNLTKNEFQIL
RVLFEHAGNIVARDDLMRELWNSDFFIDDNTLSVNVARLRKKLEEQGLVGFIETKKGIGYGLKHA

Nucleotide

• Length: 678 bp

>NTDB_id=32709 HMPREF0837_RS08950 WP_000548959.1 1715195..1715872(-) (braR) [Streptococcus pneumoniae TCH8431/19A]
ATGCACAAGATTTTATTAATAGAAGATGATCAGGTCATTCGTCAACAGATTGGGAAAATGCTCTCTGAATGGGGATTTGA
AGTGGTCCTGGTAGAAGACTTTATGGAAGTTTTGAGTCTATTTGTTCAGTCGGAACCTCATCTGGTCCTCATGGATATTG
GTTTGCCCTTGTTTAATGGTTATCACTGGTGTCAGGAAATCCGCAAGATTTCCAAGGTACCTATCATGTTTCTTTCTTCG
AGAGACCAGGCTATGGATATTGTCATGGCAATCAATATGGGGGCGGATGACTTTGTGACCAAGCCTTTTGACCAGCAGGT
TCTTTTAGCTAAGGTTCAGGGCTTGTTGCGTCGTTCCTATGAGTTTGGGCGTGATGAGAGTTTGCTGGAATATGCTGGTG
TTATCCTCAATACCAAATCCATGGATTTACATTATCAAGGGCAAGTCTTGAATTTGACCAAGAATGAATTCCAGATTTTA
CGCGTGTTATTTGAGCATGCAGGCAACATCGTAGCACGTGACGACCTGATGCGGGAACTTTGGAACAGTGACTTTTTCAT
TGATGATAATACCCTCTCTGTCAATGTGGCTCGTTTGCGTAAAAAGTTGGAGGAGCAGGGATTGGTAGGATTTATCGAGA
CCAAGAAAGGAATAGGGTACGGATTGAAGCATGCTTGA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (147-221)

3D structure

• AlphaFold DB: Q9S1K2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
braR	Staphylococcus aureus N315	48.624	96.889	0.471
vicR	Streptococcus mutans UA159	35.319	100	0.369