Detailed information NTG0325196

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: EGX68_RS08355
• Genome accession: NZ_CP033735
• Coordinates: 1618581..1619624 (-)
• Length: 347 a.a.
• NCBI ID: WP_019469615.1
• Uniprot ID: A0A6N7XY82
• Organism: Staphylococcus cohnii strain FDAARGOS_538
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1613581..1624624

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EGX68_RS08325 (EGX68_08330)	-	1614137..1615375 (-)	1239	WP_019469621.1	aminopeptidase	-
EGX68_RS08330 (EGX68_08335)	-	1615390..1615593 (-)	204	WP_019469620.1	DUF1128 family protein	-
EGX68_RS08335 (EGX68_08340)	-	1615726..1616190 (+)	465	WP_019469619.1	low molecular weight protein-tyrosine-phosphatase	-
EGX68_RS08340 (EGX68_08345)	-	1616198..1616482 (+)	285	WP_103211099.1	hypothetical protein	-
EGX68_RS08345 (EGX68_08350)	-	1616795..1617874 (+)	1080	WP_019469617.1	YihY/virulence factor BrkB family protein	-
EGX68_RS08350 (EGX68_08355)	vraR	1617962..1618591 (-)	630	WP_019469616.1	response regulator transcription factor	Regulator
EGX68_RS08355 (EGX68_08360)	vraS	1618581..1619624 (-)	1044	WP_019469615.1	sensor histidine kinase	Regulator
EGX68_RS08360 (EGX68_08365)	liaF	1619621..1620322 (-)	702	WP_019469614.1	cell wall-active antibiotics response protein LiaF	-
EGX68_RS08365 (EGX68_08370)	-	1620339..1620725 (-)	387	WP_019469613.1	hypothetical protein	-
EGX68_RS08370 (EGX68_08375)	map	1620830..1621582 (-)	753	WP_019469612.1	type I methionyl aminopeptidase	-
EGX68_RS08375 (EGX68_08380)	-	1621759..1622745 (+)	987	WP_019469611.1	aromatic acid exporter family protein	-
EGX68_RS08380 (EGX68_08385)	-	1622839..1623561 (-)	723	WP_019469610.1	type 1 glutamine amidotransferase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40030.41 Da
• Isoelectric Point: 5.8532

>NTDB_id=325196 EGX68_RS08355 WP_019469615.1 1618581..1619624(-) (vraS) [Staphylococcus cohnii strain FDAARGOS_538]
MNHYIRAIGSMLILVYSTFFAMFFIDKVFVNIIYFQGMIYTQIFGIPVLLFINLLVILLCIIVGSVLAYKINQQNHWLQD
QIERSIEGQTVGINDQNIELYNETIELYQTLVPLNQEVHRLRLKTQNLTNESYNMNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETDLKAPLDQQIPVLEKMIQDSQLEMRALLLHLRPIGLKDKSLGQGIKDLVVDLQKKVPMKVVHDI
EEFDVPKGIEDHLFRITQEAISNTLRHSKGTKVTIELFNREEYLLLRIQDDGKGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYAD

Nucleotide

• Length: 1044 bp

>NTDB_id=325196 EGX68_RS08355 WP_019469615.1 1618581..1619624(-) (vraS) [Staphylococcus cohnii strain FDAARGOS_538]
ATGAATCACTACATAAGAGCAATAGGATCAATGTTGATATTAGTTTATAGTACATTTTTCGCTATGTTTTTTATAGATAA
AGTTTTTGTGAATATTATATATTTTCAAGGCATGATTTATACGCAAATCTTTGGAATACCAGTTTTACTATTTATCAACT
TATTAGTTATATTACTTTGCATCATTGTTGGCTCAGTATTAGCGTATAAAATCAATCAACAAAATCATTGGTTACAAGAC
CAAATTGAGCGTTCTATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATAGAATTATATAATGAAACAATTGAATT
ATATCAAACGCTTGTACCGCTCAATCAAGAAGTTCATAGATTGCGTTTAAAAACACAAAATTTAACGAATGAATCATATA
ATATGAACGATGTGAAAGTTAAAAAAATAATTGAAGACGAAAGACAAAGACTGGCTCGAGAGTTACATGATTCCGTAAGC
CAGCAATTGTTTGCAGCAAGTATGATGCTCTCTGCTATTAAAGAAACTGATTTGAAAGCACCTTTAGATCAACAAATTCC
AGTATTGGAAAAAATGATCCAAGATTCACAGTTAGAAATGCGTGCCTTGCTATTGCATTTAAGACCAATTGGCTTGAAAG
ATAAATCACTTGGCCAAGGTATCAAAGATTTAGTGGTTGATTTGCAGAAAAAGGTGCCTATGAAAGTTGTACATGATATT
GAAGAATTCGACGTACCCAAAGGTATAGAAGATCATTTATTTAGAATTACACAAGAAGCAATTTCAAATACATTAAGACA
TTCAAAAGGGACAAAAGTTACAATTGAATTGTTTAATAGAGAAGAATATTTATTATTACGTATACAAGATGATGGTAAAG
GCTTTAATGTAGATGATAAGGTAGAACAAAGCTATGGGTTAAAAAATATGCGCGAACGAGCACTTGAAATAGGCGCAACG
TTTCATATAGTATCACTGCCAGATTCAGGAACACGAATTGAAGTCAAAGCCCCATTAAATAAGGAGGATTCATATGCCGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A6N7XY82

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	86.455	100	0.865