Detailed information    

insolico Bioinformatically predicted

Overview

Name   covS   Type   Regulator
Locus tag   EFD52_RS07290 Genome accession   NZ_CP033606
Coordinates   1494296..1495771 (-) Length   491 a.a.
NCBI ID   WP_010906048.1    Uniprot ID   A0A2A9ICZ0
Organism   Lactococcus lactis strain IL6288     
Function   repress the expression of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1489296..1500771
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EFD52_RS07275 (EFD52_07275) murD 1490556..1491908 (-) 1353 WP_003130748.1 UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase -
  EFD52_RS07280 (EFD52_07280) - 1492399..1492740 (-) 342 WP_010906046.1 P-II family nitrogen regulator -
  EFD52_RS07285 (EFD52_07285) - 1492872..1494113 (-) 1242 WP_003130753.1 ammonium transporter -
  EFD52_RS07290 (EFD52_07290) covS 1494296..1495771 (-) 1476 WP_010906048.1 HAMP domain-containing histidine kinase Regulator
  EFD52_RS07295 (EFD52_07295) covR 1495779..1496471 (-) 693 WP_003130756.1 response regulator transcription factor Regulator
  EFD52_RS07300 (EFD52_07300) - 1496627..1497157 (-) 531 WP_003130758.1 DUF177 domain-containing protein -
  EFD52_RS07305 (EFD52_07305) - 1497288..1497533 (-) 246 WP_003130760.1 type B 50S ribosomal protein L31 -
  EFD52_RS07310 (EFD52_07310) - 1497689..1498153 (-) 465 WP_003130761.1 hypothetical protein -
  EFD52_RS07315 (EFD52_07315) - 1498235..1498597 (-) 363 WP_010906050.1 TIGR02328 family protein -
  EFD52_RS07325 (EFD52_07325) - 1499082..1499612 (-) 531 WP_003130764.1 CHAP domain-containing protein -
  EFD52_RS07330 (EFD52_07330) - 1499673..1500509 (-) 837 WP_003130766.1 metallophosphoesterase -

Sequence

Protein


Download         Length: 491 a.a.        Molecular weight: 56195.08 Da        Isoelectric Point: 4.8253

>NTDB_id=324320 EFD52_RS07290 WP_010906048.1 1494296..1495771(-) (covS) [Lactococcus lactis strain IL6288]
MKKLFTFNKKKETVEESSAKRSIMLRWAFANTVFCFITFTLFATLTYQLTISSFIKEEQQLLTRSMDSVEEVLEKADAPL
NSSNLNTYIEATSKIQNGESEGMSLGSIIGTRKAFYIYDLNHKLLYSTNRHTFGFQNQANNEMKEIRGENPGYLVQRKII
SKSTGQVVGYLQAFYDTTTYHRISNLLLIVLLILEIVALIVAQLIGYFMANYFMKPLEKLYQGMQEMANDPTNDFEPIEI
QSGDEIEELAHVYNDMMLKMKAYLEQQNRFVSDVSHELRTPLAVLDGHINLLNRWGKNDPEVLDESLQASLDEVDRMKKM
LEEMLALARLENVDLSSEELDCDVGKVCNRALKNFQLLHDDFEIVLDNRLIYPTHARISENHFEQGLRILLDNAAKYSPD
DRKEIVITVSEDEQFVITSVSDKGIGISEEDINHLFERFFRADKARNREIGGTGLGLSILARLAENYQGEIEVNSELGLG
STFTLKFPKIK

Nucleotide


Download         Length: 1476 bp        

>NTDB_id=324320 EFD52_RS07290 WP_010906048.1 1494296..1495771(-) (covS) [Lactococcus lactis strain IL6288]
ATGAAAAAACTATTTACTTTCAATAAGAAAAAAGAGACGGTAGAGGAAAGTTCGGCTAAGCGGTCTATCATGCTTAGGTG
GGCTTTTGCTAACACCGTTTTTTGTTTTATTACTTTTACTTTGTTTGCTACTTTGACTTATCAATTGACAATCAGTTCTT
TTATTAAAGAAGAACAACAATTATTAACTCGCTCTATGGATAGTGTTGAGGAAGTCTTAGAAAAAGCAGATGCTCCTTTG
AATTCATCGAATTTGAACACATATATTGAAGCGACATCAAAGATTCAAAATGGTGAGTCTGAAGGAATGAGTTTGGGTAG
TATCATTGGGACACGGAAAGCATTTTATATTTATGACTTAAATCATAAATTATTGTATTCAACGAATCGACATACTTTTG
GTTTTCAGAATCAGGCTAATAATGAAATGAAAGAGATTCGGGGAGAAAATCCAGGTTATTTAGTTCAGAGAAAAATTATT
TCTAAGTCAACAGGACAAGTTGTGGGATACTTACAGGCTTTTTATGATACGACGACTTATCATCGAATTTCTAATCTTCT
TTTGATTGTCTTGTTAATTTTAGAAATTGTTGCCTTGATTGTCGCTCAGTTGATTGGTTATTTCATGGCTAATTACTTTA
TGAAACCATTGGAAAAACTTTATCAGGGCATGCAAGAAATGGCAAATGATCCAACAAATGATTTTGAACCGATTGAAATT
CAAAGTGGAGATGAAATCGAAGAGTTGGCTCATGTTTACAATGATATGATGTTGAAGATGAAGGCATATCTTGAACAGCA
AAATCGCTTTGTTTCTGATGTTTCTCATGAATTAAGAACACCTTTAGCTGTCTTGGATGGACATATTAACTTGTTGAATC
GATGGGGGAAAAATGATCCAGAAGTATTAGATGAATCTTTGCAGGCAAGTTTAGATGAAGTTGATCGAATGAAGAAAATG
CTTGAGGAGATGTTGGCTCTTGCTCGCCTTGAAAATGTTGACTTATCAAGTGAAGAACTGGATTGTGATGTTGGAAAAGT
TTGTAATCGGGCCCTTAAGAATTTTCAGCTTTTGCATGATGATTTTGAAATAGTGCTTGATAACCGGCTTATTTATCCCA
CTCATGCGCGAATTTCAGAAAATCATTTTGAACAAGGGTTACGAATTCTGTTAGATAATGCTGCTAAATACTCTCCTGAT
GATCGTAAAGAAATCGTGATTACTGTTTCTGAGGATGAACAGTTTGTGATTACGAGTGTATCTGACAAAGGAATTGGAAT
TTCAGAAGAAGATATTAATCATCTTTTTGAGCGTTTCTTTAGAGCGGACAAGGCTCGCAATCGAGAAATTGGTGGAACTG
GTTTAGGTTTATCAATTTTAGCTCGATTGGCAGAAAATTATCAAGGGGAAATTGAGGTAAATTCAGAACTGGGTCTTGGT
TCAACTTTTACACTAAAATTCCCGAAAATAAAATAA

Domains

Predicted by InterproScan.

ArlS sensor domain (ArlS_N)

(54-185)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(380-489)

HAMP domain (HAMP)

(208-258)

His Kinase A (phospho-acceptor) domain (HisKA)

(267-332)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2A9ICZ0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covS Lactococcus lactis subsp. lactis strain DGCC12653

100

100

1

Multiple sequence alignment