Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   SMI_RS09760 Genome accession   NC_013853
Coordinates   1987770..1989719 (-) Length   649 a.a.
NCBI ID   WP_000018198.1    Uniprot ID   -
Organism   Streptococcus mitis B6     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1982770..1994719
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMI_RS09735 (smi_1926) - 1983463..1984407 (+) 945 WP_000815623.1 magnesium transporter CorA family protein -
  SMI_RS09740 (smi_1927) - 1984419..1985096 (+) 678 WP_000078366.1 DUF1129 domain-containing protein -
  SMI_RS09745 (smi_1928) - 1985389..1986420 (+) 1032 WP_164925574.1 S66 family peptidase -
  SMI_RS09750 (smi_1929) - 1986588..1987151 (-) 564 WP_000166578.1 DNA-3-methyladenine glycosylase I -
  SMI_RS09755 (smi_1930) ruvA 1987161..1987754 (-) 594 WP_000273417.1 Holliday junction branch migration protein RuvA Machinery gene
  SMI_RS09760 (smi_1931) hexB 1987770..1989719 (-) 1950 WP_000018198.1 DNA mismatch repair endonuclease MutL Machinery gene
  SMI_RS09765 (smi_1933) - 1989925..1990365 (+) 441 WP_000861978.1 LytTR family DNA-binding domain-containing protein -
  SMI_RS09770 (smi_1934) - 1990362..1990820 (+) 459 WP_000743981.1 DUF3021 domain-containing protein -
  SMI_RS09775 (smi_1935) nrdI 1990868..1991332 (-) 465 WP_000849614.1 class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI -
  SMI_RS09780 (smi_1936) - 1991410..1991943 (-) 534 WP_164925575.1 ABC transporter permease -
  SMI_RS09785 (smi_1937) - 1992001..1993287 (-) 1287 WP_000278886.1 response regulator transcription factor -

Sequence

Protein


Download         Length: 649 a.a.        Molecular weight: 73360.66 Da        Isoelectric Point: 5.1717

>NTDB_id=32340 SMI_RS09760 WP_000018198.1 1987770..1989719(-) (hexB) [Streptococcus mitis B6]
MSHIIELPEVLANQIAAGEVIERPASVVKELVENAIDAGSSQIIIEIEEAGLKKIQITDNGHGIAHDEVELALRRHATSK
IKNQADLFRIRTLGFRGEALPSIASVSVLTLLTAVDGASHGTKLVARGGEVEEVIPATSPVGTKVCVEDLFFNTPARLKY
MKSQQAELSHIIDIVNRLGLAHPEISFSLISDGKEMTRTAGTGQLRQAIAGIYGLASAKKMIEIENSDLDFEITGFVSLP
ELTRANRNYISLFINGRYIKNFLLNRAILDGYGSKLMVGRFPLAVIHIHIDPYLADVNVHPTKQEVRISKEKELMTLVSE
AIANSLKEQTLIPDALENLAKSTVRNREKVEQTILPLKENTLYYEQTEANRSSQAEVADYQVELTDEGQDLTLFAKETLD
QLTKPAKLRFAERKPANYDQLDHPELDLASLDKAYDKLEREESSSFPELEFFGQMHGTYLFAQGRDGLYIIDQHAAQERV
KYEEYRESIGNVDQSQQQLLVPYIFEFPADDALRIKERMALLEEVGVFLAEYGENQFILREHPIWMAEEEIESGIYEMCD
MLLLTKEVSIKKYRAELAIMMSCKRSIKANHRIDDHSARQLLYQLSQCDNPYNCPHGRPVLVHFTKSDMEKMFRRIQENH
TSLRELGKY

Nucleotide


Download         Length: 1950 bp        

>NTDB_id=32340 SMI_RS09760 WP_000018198.1 1987770..1989719(-) (hexB) [Streptococcus mitis B6]
ATGTCTCATATTATTGAATTGCCAGAGGTGCTGGCAAACCAGATTGCAGCTGGAGAGGTTATCGAGCGTCCAGCTAGCGT
TGTTAAGGAGCTGGTAGAAAACGCCATTGACGCGGGCTCTAGTCAGATTATCATTGAGATCGAGGAAGCTGGTCTCAAGA
AGATTCAAATCACGGATAATGGTCATGGAATTGCTCACGATGAGGTGGAATTGGCCTTGCGTCGTCATGCGACCAGTAAG
ATAAAAAATCAAGCAGATCTCTTTCGGATTCGGACGCTTGGTTTTCGTGGTGAAGCCCTGCCCTCTATCGCGTCTGTCAG
TGTACTGACTCTGTTGACGGCGGTGGATGGTGCGAGTCATGGGACTAAGCTCGTCGCACGTGGGGGAGAAGTAGAAGAAG
TCATCCCAGCGACTAGTCCTGTGGGGACCAAGGTTTGTGTGGAGGACCTATTTTTCAATACGCCTGCCCGTCTCAAGTAT
ATGAAGAGCCAGCAAGCGGAGCTGTCTCATATCATTGATATTGTCAACCGTCTGGGTTTGGCCCATCCTGAGATTTCTTT
CAGCTTGATTAGTGATGGCAAGGAAATGACGCGGACAGCTGGGACTGGTCAACTGCGTCAAGCTATTGCAGGGATTTACG
GTTTGGCGAGTGCCAAGAAGATGATTGAAATTGAGAATTCTGATCTAGATTTCGAAATTACAGGTTTTGTGTCCTTGCCT
GAGTTGACTCGAGCTAATCGCAACTATATCAGCCTCTTCATCAATGGTCGTTATATCAAGAATTTCCTACTCAATCGTGC
TATTCTTGACGGCTATGGCAGTAAGCTCATGGTAGGCCGTTTTCCACTGGCTGTCATTCATATCCATATTGACCCCTATC
TAGCGGATGTCAATGTGCATCCGACTAAGCAAGAGGTGCGGATTTCCAAGGAAAAAGAACTGATGACCCTGGTTTCAGAA
GCTATTGCAAACAGTCTCAAGGAGCAGACCTTGATACCTGATGCCTTGGAAAATCTTGCCAAATCGACCGTGCGTAATCG
TGAGAAGGTGGAGCAAACTATTCTCCCACTCAAAGAAAATACGCTTTACTATGAGCAAACAGAGGCAAATAGATCTAGTC
AAGCTGAGGTGGCTGATTATCAGGTAGAATTGACTGATGAAGGGCAGGATTTAACCCTGTTTGCCAAAGAAACCTTGGAC
CAATTGACCAAGCCAGCAAAACTGCGTTTTGCAGAGAGAAAACCTGCTAACTATGACCAATTAGACCATCCTGAGTTGGA
CCTAGCTAGTCTGGATAAGGCCTATGACAAACTGGAGCGAGAAGAATCATCAAGCTTCCCAGAGTTGGAATTTTTCGGGC
AAATGCATGGAACCTATCTCTTTGCCCAGGGGAGAGATGGGCTTTACATCATAGATCAACACGCAGCTCAGGAACGGGTC
AAATACGAGGAGTACCGTGAGAGCATTGGCAATGTTGACCAGAGCCAGCAGCAACTGCTAGTGCCCTACATCTTTGAATT
TCCTGCGGATGATGCCCTGCGTATCAAGGAAAGAATGGCACTTTTGGAGGAAGTGGGTGTCTTTCTAGCAGAGTACGGGG
AAAATCAATTCATCTTACGTGAACATCCTATTTGGATGGCAGAGGAGGAGATTGAGTCAGGTATCTATGAGATGTGCGAC
ATGCTCCTTTTGACCAAGGAAGTTTCTATCAAGAAATACCGAGCAGAGTTGGCTATTATGATGTCCTGCAAGCGGTCTAT
CAAGGCCAATCATCGTATTGACGACCATTCAGCTAGACAACTCCTCTATCAGCTTTCTCAATGTGACAATCCCTATAACT
GTCCTCACGGACGTCCTGTTTTGGTGCATTTCACCAAGTCGGATATGGAAAAGATGTTCCGACGTATTCAGGAAAATCAC
ACCAGTCTCCGTGAGTTGGGGAAATATTAA

Domains

Predicted by InterProScan.

MutL C terminal dimerisation domain (MutL_C)

(450-592)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-107)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

97.535

100

0.975

Multiple sequence alignment