Detailed information NTG0316361

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SaO326_RS10190
• Genome accession: NZ_CP032481
• Coordinates: 1991135..1992178 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain O326
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1986135..1997178

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SaO326_RS10160 (SaO326_01856)	-	1986556..1987812 (-)	1257	WP_001793428.1	aminopeptidase	-
SaO326_RS10165 (SaO326_01857)	-	1987815..1988015 (-)	201	WP_000180460.1	DUF1128 family protein	-
SaO326_RS10170 (SaO326_01858)	-	1988162..1988626 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
SaO326_RS10175 (SaO326_01859)	-	1988633..1988908 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SaO326_RS10180 (SaO326_01860)	-	1989186..1990403 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
SaO326_RS10185 (SaO326_01861)	vraR	1990516..1991145 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
SaO326_RS10190 (SaO326_01862)	vraS	1991135..1992178 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SaO326_RS10195 (SaO326_01863)	liaF	1992175..1992876 (-)	702	WP_000149070.1	cell wall-active antibiotics response protein LiaF	-
SaO326_RS10200 (SaO326_01864)	-	1992891..1993277 (-)	387	WP_001110179.1	hypothetical protein	-
SaO326_RS10205 (SaO326_01865)	map	1993494..1994252 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
SaO326_RS10215 (SaO326_01866)	-	1994779..1995765 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
SaO326_RS10220 (SaO326_01867)	-	1995954..1996367 (-)	414	WP_025174666.1	hypothetical protein	-
SaO326_RS10225	-	1996396..1996506 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=316361 SaO326_RS10190 WP_001017131.1 1991135..1992178(-) (vraS) [Staphylococcus aureus strain O326]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=316361 SaO326_RS10190 WP_001017131.1 1991135..1992178(-) (vraS) [Staphylococcus aureus strain O326]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATTTTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATT
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCGGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1