NTDB

Overview

Name	comR	Type	Regulator
Locus tag	E5Q10_RS09480	Genome accession	NZ_CP038808
Coordinates	1774532..1775431 (-)	Length	299 a.a.
NCBI ID	WP_000904866.1	Uniprot ID	Q8DND0
Organism	Streptococcus pneumoniae strain R6CIB17
Function	activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1769532..1780431

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E5Q10_RS09460 (E5Q10_09455)	rsmA	1770286..1771158 (-)	873	WP_001216869.1	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	-
E5Q10_RS09465 (E5Q10_09460)	-	1771289..1771597 (-)	309	WP_000333257.1	hypothetical protein	-
E5Q10_RS09470 (E5Q10_09465)	-	1771590..1772231 (-)	642	WP_000565531.1	ABC transporter ATP-binding protein	-
E5Q10_RS09475 (E5Q10_09470)	-	1772233..1774263 (-)	2031	WP_000825280.1	bacteriocin-associated integral membrane family protein	-
E5Q10_RS09480 (E5Q10_09475)	comR	1774532..1775431 (-)	900	WP_000904866.1	helix-turn-helix domain-containing protein	Regulator
E5Q10_RS09485 (E5Q10_09480)	rnmV	1775503..1776063 (-)	561	WP_000664448.1	ribonuclease M5	-
E5Q10_RS09490 (E5Q10_09485)	-	1776063..1776836 (-)	774	WP_000575607.1	TatD family hydrolase	-
E5Q10_RS09500 (E5Q10_09495)	-	1777142..1777861 (-)	720	Protein_1777	DUF1542 domain-containing protein	-
E5Q10_RS09505 (E5Q10_09500)	rpmH	1778070..1778204 (-)	135	WP_000831905.1	50S ribosomal protein L34	-
E5Q10_RS09510 (E5Q10_09505)	-	1778349..1779563 (-)	1215	WP_000666469.1	pyridoxal phosphate-dependent aminotransferase	-
E5Q10_RS09515 (E5Q10_09510)	-	1779719..1780012 (-)	294	WP_000977365.1	hypothetical protein	-

Sequence

Protein

Download Length: 299 a.a. Molecular weight: 35191.98 Da Isoelectric Point: 4.8875

                                >NTDB_id=315919 E5Q10_RS09480 WP_000904866.1 1774532..1775431(-) (comR) [Streptococcus pneumoniae strain R6CIB17]

MLIGQKIKEIRIEKGISRPDFCGDEQGLTVRQLSRIESGASQPSLPKLAYIARRLGVPVYSLMPDFSALPSAYLELKYQI

LREPIYGKEEEYDKKEACLEEIYKTYFDNLPKEEQLACEVLQACLDTSRTRRPEYAELILEEHMPQIIEKEAYSINDMLL

IRLFFYQMLIRKDLAKFINQIEKLMLFLLEQKKVTQIENYFIIRDTLISGMCCLEKVGVTDCFNDYLSCLQEIMDKTQDY

QKKPLVFMFLWKQALRVERDFSLAESFYQSSKTFAKLIGDGFLVKELTEEWQEDVKKYL

Nucleotide

Download Length: 900 bp

                                >NTDB_id=315919 E5Q10_RS09480 WP_000904866.1 1774532..1775431(-) (comR) [Streptococcus pneumoniae strain R6CIB17]

ATGTTAATTGGTCAAAAAATTAAAGAGATTCGGATAGAAAAAGGAATTAGTCGTCCAGATTTTTGTGGAGATGAGCAAGG

ACTGACAGTTCGTCAACTGTCGCGAATTGAAAGTGGAGCTTCGCAACCGAGTTTGCCCAAGTTAGCCTATATTGCTCGCC

GGCTAGGAGTTCCAGTTTATAGCCTTATGCCGGATTTTTCAGCTCTTCCTTCTGCTTATTTAGAATTGAAATACCAGATT

TTACGTGAACCAATCTATGGTAAAGAAGAGGAGTACGATAAGAAGGAAGCGTGTTTGGAAGAGATTTATAAAACATACTT

TGATAATCTTCCTAAAGAAGAACAATTAGCATGTGAAGTATTGCAGGCGTGTTTGGATACTTCTAGAACTAGAAGGCCTG

AATATGCAGAGTTAATACTTGAGGAACATATGCCTCAGATTATAGAAAAAGAAGCTTATTCAATAAATGATATGTTGTTG

ATTCGTTTGTTTTTTTATCAAATGCTCATTAGAAAAGATCTTGCCAAATTTATAAATCAAATCGAAAAGCTAATGCTCTT

TCTTTTGGAACAGAAGAAGGTAACTCAAATAGAGAATTACTTTATAATTAGAGATACTCTTATTTCAGGAATGTGTTGTC

TTGAAAAGGTAGGAGTAACTGATTGTTTTAATGATTATCTATCGTGTTTACAAGAAATTATGGATAAAACTCAAGATTAT

CAAAAGAAACCTCTTGTATTTATGTTTTTGTGGAAGCAAGCATTAAGAGTAGAAAGAGATTTTAGTTTAGCTGAATCATT

TTATCAGTCTTCTAAAACATTTGCGAAGCTAATTGGAGATGGATTTCTAGTAAAGGAATTGACAGAGGAATGGCAAGAGG

ATGTCAAAAAATATTTATAA

Domains

Predicted by InterProScan.

Helix-turn-helix (HTH_3)

(7-59)

ComR tetratricopeptide (ComR_TPR)

(70-291)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	Q8DND0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comR	Streptococcus mutans UA159	37.755	98.328	0.371
comR	Streptococcus suis P1/7	37.457	97.324	0.365
comR	Streptococcus suis 05ZYH33	37.457	97.324	0.365

Detailed information NTG0315919