Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   E3169_RS17515 Genome accession   NZ_CP038408
Coordinates   3436132..3436788 (-) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli O157:H7 strain 86-24     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 3431132..3441788
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E3169_RS17475 (E3169_18040) - 3431135..3432268 (-) 1134 WP_032161728.1 IS30-like element IS30 family transposase -
  E3169_RS17480 (E3169_18045) - 3432210..3432404 (-) 195 WP_115801851.1 hypothetical protein -
  E3169_RS17485 (E3169_18050) - 3432425..3432706 (-) 282 WP_001303543.1 hypothetical protein -
  E3169_RS17505 (E3169_18070) pgsA 3433698..3434246 (-) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  E3169_RS17510 (E3169_18075) uvrC 3434303..3436135 (-) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  E3169_RS17515 (E3169_18080) letA 3436132..3436788 (-) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  E3169_RS28350 (E3169_18085) - 3436930..3437046 (+) 117 WP_001302039.1 hypothetical protein -
  E3169_RS17520 (E3169_18090) yecU 3437084..3437260 (+) 177 WP_001302050.1 protein YecU -
  E3169_RS17525 (E3169_18095) yecF 3437247..3437471 (+) 225 WP_000106479.1 DUF2594 family protein YecF -
  E3169_RS17530 (E3169_18100) sdiA 3437539..3438261 (-) 723 WP_001154288.1 transcriptional regulator SdiA -
  E3169_RS17535 (E3169_18105) tcyN 3438491..3439243 (-) 753 WP_001273005.1 L-cystine ABC transporter ATP-binding protein TcyN -
  E3169_RS17540 (E3169_18110) tcyL 3439240..3439908 (-) 669 WP_001158226.1 cystine ABC transporter permease -
  E3169_RS17545 (E3169_18115) dcyD 3439923..3440909 (-) 987 WP_001128226.1 D-cysteine desulfhydrase -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=314181 E3169_RS17515 WP_000611328.1 3436132..3436788(-) (letA) [Escherichia coli O157:H7 strain 86-24]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=314181 E3169_RS17515 WP_000611328.1 3436132..3436788(-) (letA) [Escherichia coli O157:H7 strain 86-24]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGCCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTAAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATCCGTTCTGTCTATTCTGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CATTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACGAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482

Multiple sequence alignment