Detailed information NTG0031365

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: SEZ_RS03075
• Genome accession: NC_011134
• Coordinates: 630667..632919 (-)
• Length: 750 a.a.
• NCBI ID: WP_012515248.1
• Uniprot ID: B4U1V5
• Organism: Streptococcus equi subsp. zooepidemicus MGCS10565
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 625667..637919

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SEZ_RS03060 (Sez_0602)	ileS	626443..629241 (+)	2799	WP_012515245.1	isoleucine--tRNA ligase	-
SEZ_RS03065 (Sez_0603)	-	629710..630012 (-)	303	WP_012515246.1	DUF1827 family protein	-
SEZ_RS03070 (Sez_0604)	-	630074..630520 (-)	447	WP_012515247.1	NUDIX hydrolase	-
SEZ_RS03075 (Sez_0605)	clpE	630667..632919 (-)	2253	WP_012515248.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
SEZ_RS03080 (Sez_0606)	-	633202..633432 (+)	231	WP_012515249.1	DUF1797 family protein	-
SEZ_RS03085 (Sez_0608)	-	633877..635202 (-)	1326	WP_012515251.1	LPXTG cell wall anchor domain-containing protein	-
SEZ_RS03090 (Sez_0609)	-	635548..636232 (+)	685	Protein_577	amino acid ABC transporter permease	-
SEZ_RS03095 (Sez_0611)	-	636234..636971 (+)	738	WP_012515254.1	amino acid ABC transporter ATP-binding protein	-

Sequence

Protein

• Length: 750 a.a.
• Molecular weight: 83831.25 Da
• Isoelectric Point: 5.6718

>NTDB_id=31365 SEZ_RS03075 WP_012515248.1 630667..632919(-) (clpE) [Streptococcus equi subsp. zooepidemicus MGCS10565]
MLCQNCNLNESTIHLYTSINGKQRQIDLCQNCYQIMKTDPKNPILGGYNGNQKAQQPSQNPFFDDFFGDLNNFRAFGQLP
NTPPTQSGGQHGGGHNGYRPNQTQPAQETNKGLLEEFGINITEMAKRGDIDPVIGRDDEIIRVIEILNRRTKNNPVLIGE
PGVGKTAVVEGLAQKIVDGDVPQKLQSKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRKRHDVILFIDEIHEIVGAGA
VGDGSMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQAKYEDYHHVKYSQS
AIEAAANLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKDIDKRLIEAENLKTQATRDEDYERAAYFRDQIAKYKE
MQAQKLDEQDIPIITDKTIEAIVEQKTNIPVGDLKEKEQSQLVNLAADLKKHVIGQDDAVDKIAKAIRRNRVGLGAPNRP
IGSFLFVGPTGVGKTELSKQLAIELFGSADNMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEQVRRNPYSLILLD
EIEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKTEASVGFGAAREGRTNSVLGELSHFFSPEFMNR
FDGIIEFQPLSKDNLLHIVHLMLDDVNHRLAHNNIRLDVTQKVKEKLVELGYDPKMGARPLRRTIQDYIEDAITDFYLEH
PAEKDLRAVLTSNGHIIIKPVVKSQAKQAD

Nucleotide

• Length: 2253 bp

>NTDB_id=31365 SEZ_RS03075 WP_012515248.1 630667..632919(-) (clpE) [Streptococcus equi subsp. zooepidemicus MGCS10565]
ATGCTTTGTCAAAACTGTAATTTAAATGAATCAACCATTCATCTTTATACAAGCATTAACGGAAAGCAAAGGCAGATTGA
CCTCTGTCAAAATTGCTACCAAATCATGAAAACAGACCCTAAAAATCCTATCTTAGGAGGCTATAATGGCAACCAAAAGG
CGCAGCAGCCTTCTCAAAACCCTTTCTTTGATGACTTTTTTGGTGACCTCAACAACTTTAGAGCCTTTGGTCAGCTCCCC
AATACACCACCTACCCAATCAGGAGGCCAGCATGGCGGAGGTCACAATGGCTACCGTCCCAATCAAACACAGCCAGCACA
AGAGACTAACAAAGGTTTGCTTGAGGAATTCGGCATTAATATCACTGAAATGGCCAAGCGCGGTGATATTGATCCTGTCA
TCGGACGTGACGATGAGATTATCCGCGTCATCGAAATTCTCAACCGTCGTACCAAAAATAACCCTGTCCTAATCGGAGAA
CCAGGTGTTGGTAAGACTGCTGTCGTTGAAGGCCTTGCTCAAAAAATCGTTGATGGTGATGTGCCACAAAAGCTACAGAG
TAAGCAGGTGATTCGCCTTGATGTGGTTAGCCTCGTTCAGGGGACAGGTATTCGTGGCCAATTTGAAGAGCGCATGCAAA
AGCTCATGGAGGAAATCCGCAAGCGCCATGACGTTATCCTTTTTATTGATGAAATCCATGAAATTGTGGGAGCCGGGGCA
GTTGGTGATGGCAGTATGGACGCAGGAAATATTTTAAAGCCAGCACTTGCTCGTGGTGAGCTTCAATTAGTGGGAGCCAC
CACTCTCAATGAATACCGCATTATCGAAAAGGACGCAGCCCTCGAACGACGCATGCAGCCGGTTAAGGTAGATGAGCCCT
CGGTTGAAGAAACAATCACGATCCTAAAAGGAATCCAAGCCAAATACGAGGACTATCACCATGTCAAATATAGCCAGTCG
GCTATTGAAGCAGCTGCTAACCTCTCCAACCGCTATATTCAAGACCGCTTCTTGCCTGATAAGGCCATTGACCTGCTAGA
TGAAGCCGGCTCAAAGATGAACCTAACCCTTAACTTTGTTGACCCCAAAGACATTGATAAGCGTTTGATTGAGGCTGAAA
ACCTCAAGACACAAGCCACACGTGATGAGGATTATGAGCGAGCAGCCTATTTCCGCGATCAAATCGCCAAATATAAAGAA
ATGCAGGCTCAAAAGCTAGATGAGCAGGATATTCCAATCATCACTGACAAGACCATCGAAGCAATCGTTGAGCAAAAAAC
CAATATTCCAGTTGGTGATTTAAAGGAAAAGGAACAATCACAGCTAGTCAATCTGGCTGCTGATCTCAAAAAGCATGTTA
TCGGTCAAGACGATGCTGTTGATAAAATTGCAAAAGCTATCCGTCGTAATCGTGTTGGACTGGGAGCCCCAAATCGTCCT
ATCGGCTCCTTCCTCTTTGTTGGCCCAACTGGTGTCGGTAAAACAGAGCTTTCCAAGCAATTAGCCATTGAGCTTTTTGG
CTCTGCTGATAACATGATTCGCTTTGACATGTCTGAATACATGGAAAAGCACGCTGTGGCTAAGCTTGTCGGTGCCCCTC
CCGGCTACGTCGGCTATGAGGAGGCAGGTCAGTTAACAGAGCAGGTGCGCCGCAACCCTTACTCGCTCATTTTGTTAGAT
GAGATCGAAAAGGCTCACCCTGATGTCATGCACATGTTTTTACAGGTCCTAGATGACGGACGATTAACCGACGGACAAGG
ACGTACCGTTAGCTTTAAGGACACTATTATCATCATGACATCAAATGCTGGCACTGGCAAAACAGAGGCCTCAGTAGGCT
TTGGCGCTGCTAGAGAAGGGCGGACAAACTCTGTTTTAGGAGAGCTCAGTCATTTCTTTAGCCCCGAGTTCATGAATCGC
TTTGATGGCATTATTGAGTTTCAGCCACTAAGCAAGGACAATCTTTTACATATCGTTCATTTAATGCTCGATGATGTTAA
CCACCGCCTTGCTCACAATAACATTCGCCTTGATGTCACCCAAAAGGTCAAAGAAAAGCTCGTTGAGCTAGGCTATGATC
CTAAGATGGGAGCACGACCATTGCGCCGCACCATTCAGGACTACATTGAGGATGCCATTACCGACTTCTACCTTGAGCAC
CCAGCAGAAAAAGACCTGCGAGCTGTCCTGACCTCTAATGGACACATTATAATCAAGCCTGTAGTCAAATCTCAGGCGAA
GCAGGCGGACTAA

Domains

Predicted by InterproScan.

• ATPase family associated with various cellular activities (AAA) (AAA) (156-269)

• AAA domain (Cdc48 subfamily) (AAA_2) (479-642)

• AAA lid domain (AAA_lid_9) (294-391)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (650-724)

3D structure

• AlphaFold DB: B4U1V5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	84.791	99.067	0.84
clpE	Streptococcus pneumoniae Rx1	82.361	100	0.828
clpE	Streptococcus pneumoniae D39	82.361	100	0.828
clpE	Streptococcus pneumoniae R6	82.361	100	0.828
clpE	Streptococcus pneumoniae TIGR4	82.228	100	0.827
clpC	Lactococcus lactis subsp. cremoris KW2	75.499	100	0.756
clpC	Bacillus subtilis subsp. subtilis str. 168	51.07	87.2	0.445
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	46.573	85.6	0.399
clpC	Streptococcus pneumoniae Rx1	48.065	82.667	0.397
clpC	Streptococcus pneumoniae D39	48.065	82.667	0.397
clpC	Streptococcus pneumoniae TIGR4	47.903	82.667	0.396
clpC	Streptococcus mutans UA159	47.343	82.8	0.392
clpC	Streptococcus thermophilus LMD-9	46.349	84	0.389
clpC	Streptococcus thermophilus LMG 18311	46.032	84	0.387