Detailed information NTG0309654

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DD548_RS05095
• Genome accession: NZ_CP031673
• Coordinates: 961545..962588 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain MOZ66
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 956545..967588

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DD548_RS05050 (DD548_05050)	-	956974..957084 (+)	111	WP_001790257.1	hypothetical protein	-
DD548_RS05055 (DD548_05055)	-	957113..957526 (+)	414	WP_001549145.1	hypothetical protein	-
DD548_RS05065 (DD548_05065)	-	957957..958943 (-)	987	WP_000999713.1	FUSC family protein	-
DD548_RS05080 (DD548_05080)	map	959471..960229 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
DD548_RS05085 (DD548_05085)	-	960446..960832 (+)	387	WP_001110179.1	hypothetical protein	-
DD548_RS05090 (DD548_05090)	liaF	960847..961548 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
DD548_RS05095 (DD548_05095)	vraS	961545..962588 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
DD548_RS05100 (DD548_05100)	vraR	962578..963207 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
DD548_RS05105 (DD548_05105)	-	963323..964540 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
DD548_RS05110 (DD548_05110)	-	964818..965093 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
DD548_RS05115 (DD548_05115)	-	965100..965564 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
DD548_RS05120 (DD548_05120)	-	965711..965911 (+)	201	WP_000180461.1	DUF1128 family protein	-
DD548_RS05125 (DD548_05125)	-	965914..967170 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=309654 DD548_RS05095 WP_001017131.1 961545..962588(+) (vraS) [Staphylococcus aureus strain MOZ66]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=309654 DD548_RS05095 WP_001017131.1 961545..962588(+) (vraS) [Staphylococcus aureus strain MOZ66]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1