Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   DZL40_RS08620 Genome accession   NZ_CP031639
Coordinates   1714453..1716897 (-) Length   814 a.a.
NCBI ID   WP_011018294.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain MGAS7914     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1712318..1750087 1714453..1716897 within 0


Gene organization within MGE regions


Location: 1712318..1750087
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DZL40_RS08610 (DZL40_08600) groL 1712318..1713949 (-) 1632 WP_129846776.1 chaperonin GroEL -
  DZL40_RS08615 (DZL40_08605) groES 1713985..1714275 (-) 291 WP_002991292.1 co-chaperone GroES -
  DZL40_RS08620 (DZL40_08610) clpC 1714453..1716897 (-) 2445 WP_011018294.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  DZL40_RS08625 (DZL40_08615) - 1716897..1717358 (-) 462 WP_002982312.1 CtsR family transcriptional regulator -
  DZL40_RS08630 (DZL40_08620) - 1717554..1717757 (-) 204 WP_002991299.1 cold-shock protein -
  DZL40_RS08635 (DZL40_08625) - 1718347..1719417 (-) 1071 WP_000179397.1 site-specific integrase -
  DZL40_RS08640 (DZL40_08630) - 1719539..1719943 (-) 405 WP_001173134.1 DUF4429 domain-containing protein -
  DZL40_RS08645 (DZL40_08635) - 1719996..1720376 (-) 381 WP_000762727.1 ImmA/IrrE family metallo-endopeptidase -
  DZL40_RS08650 (DZL40_08640) - 1720383..1720745 (-) 363 WP_000114553.1 helix-turn-helix transcriptional regulator -
  DZL40_RS08660 (DZL40_08650) - 1721031..1721195 (+) 165 WP_000511144.1 hypothetical protein -
  DZL40_RS08665 (DZL40_08655) - 1721178..1721648 (-) 471 WP_001052630.1 hypothetical protein -
  DZL40_RS08670 (DZL40_08660) - 1721709..1721918 (+) 210 WP_000082755.1 helix-turn-helix transcriptional regulator -
  DZL40_RS08675 (DZL40_08665) - 1721921..1722631 (+) 711 WP_001002368.1 ORF6C domain-containing protein -
  DZL40_RS08680 (DZL40_08670) - 1722691..1722975 (+) 285 WP_000998973.1 hypothetical protein -
  DZL40_RS08685 (DZL40_08675) - 1722992..1723207 (+) 216 WP_001061697.1 hypothetical protein -
  DZL40_RS08690 (DZL40_08680) dnaB 1723216..1724547 (+) 1332 WP_000343908.1 replicative DNA helicase -
  DZL40_RS08695 (DZL40_08685) - 1724547..1725152 (+) 606 WP_000988139.1 hypothetical protein -
  DZL40_RS08700 (DZL40_08690) - 1725130..1725876 (+) 747 WP_000079054.1 conserved phage C-terminal domain-containing protein -
  DZL40_RS08705 (DZL40_08695) - 1725877..1726698 (+) 822 WP_001067867.1 ATP-binding protein -
  DZL40_RS08710 (DZL40_08700) - 1726698..1726760 (+) 63 Protein_1616 DNA cytosine methyltransferase -
  DZL40_RS09765 - 1726741..1726896 (+) 156 WP_153204894.1 hypothetical protein -
  DZL40_RS08715 (DZL40_08705) - 1726889..1727380 (+) 492 WP_000169322.1 MazG-like family protein -
  DZL40_RS08720 (DZL40_08710) - 1727380..1727709 (+) 330 WP_000793494.1 DUF1372 family protein -
  DZL40_RS09710 (DZL40_08715) - 1727727..1728065 (+) 339 WP_340639386.1 DUF3310 domain-containing protein -
  DZL40_RS08730 (DZL40_08720) - 1728062..1728268 (+) 207 WP_000748199.1 hypothetical protein -
  DZL40_RS08735 (DZL40_08725) ssb 1728258..1728674 (+) 417 WP_000609566.1 single-stranded DNA-binding protein Machinery gene
  DZL40_RS08740 (DZL40_08730) - 1728684..1728944 (+) 261 WP_001008140.1 hypothetical protein -
  DZL40_RS08745 (DZL40_08735) - 1728941..1729288 (+) 348 WP_000776714.1 helix-turn-helix transcriptional regulator -
  DZL40_RS08750 (DZL40_08740) - 1729285..1729749 (+) 465 WP_000163169.1 hypothetical protein -
  DZL40_RS08755 (DZL40_08745) - 1729859..1730401 (+) 543 WP_001028147.1 site-specific integrase -
  DZL40_RS08760 (DZL40_08755) - 1730691..1730978 (+) 288 WP_000651009.1 hypothetical protein -
  DZL40_RS08765 (DZL40_08760) - 1731101..1731337 (+) 237 WP_223846017.1 HNH endonuclease -
  DZL40_RS08770 (DZL40_08765) - 1731425..1731910 (+) 486 WP_000601035.1 hypothetical protein -
  DZL40_RS08775 (DZL40_08770) - 1731903..1733615 (+) 1713 WP_000230004.1 terminase TerL endonuclease subunit -
  DZL40_RS08780 (DZL40_08775) - 1733624..1734766 (+) 1143 WP_001067328.1 phage portal protein -
  DZL40_RS08785 (DZL40_08780) - 1734816..1735358 (+) 543 WP_000413200.1 HK97 family phage prohead protease -
  DZL40_RS08790 (DZL40_08785) - 1735369..1736631 (+) 1263 WP_000749070.1 phage major capsid protein -
  DZL40_RS08795 (DZL40_08790) - 1736652..1736987 (+) 336 WP_000153862.1 hypothetical protein -
  DZL40_RS08800 (DZL40_08795) - 1736984..1737289 (+) 306 WP_000842789.1 head-tail adaptor protein -
  DZL40_RS08805 (DZL40_08800) - 1737289..1737636 (+) 348 WP_001074486.1 hypothetical protein -
  DZL40_RS08810 (DZL40_08805) - 1737623..1737967 (+) 345 WP_000508738.1 hypothetical protein -
  DZL40_RS08815 (DZL40_08810) - 1737982..1738665 (+) 684 WP_000222195.1 hypothetical protein -
  DZL40_RS09850 - 1738665..1738856 (+) 192 WP_242493980.1 hypothetical protein -
  DZL40_RS09855 - 1738898..1739140 (+) 243 WP_242493981.1 hypothetical protein -
  DZL40_RS09900 (DZL40_08820) - 1739179..1739307 (+) 129 WP_011058372.1 hypothetical protein -
  DZL40_RS08830 (DZL40_08825) - 1739326..1742061 (+) 2736 WP_000140779.1 phage tail tape measure protein -
  DZL40_RS08835 (DZL40_08830) - 1742058..1742780 (+) 723 WP_000161557.1 hypothetical protein -
  DZL40_RS08840 (DZL40_08835) - 1742781..1746455 (+) 3675 WP_001895725.1 phage tail spike protein -
  DZL40_RS08845 (DZL40_08840) - 1746472..1746702 (+) 231 WP_001071121.1 hypothetical protein -
  DZL40_RS08850 (DZL40_08845) - 1746705..1747043 (+) 339 WP_000213866.1 hypothetical protein -
  DZL40_RS08855 (DZL40_08850) - 1747078..1747488 (+) 411 WP_001135353.1 hypothetical protein -
  DZL40_RS08860 (DZL40_08855) - 1747491..1747820 (+) 330 WP_000192161.1 phage holin -
  DZL40_RS08865 (DZL40_08860) - 1747824..1749230 (+) 1407 WP_000405192.1 peptidoglycan amidohydrolase family protein -
  DZL40_RS08870 (DZL40_08865) - 1749437..1749622 (+) 186 WP_000139836.1 type II toxin-antitoxin system HicA family toxin -
  DZL40_RS08875 (DZL40_08870) - 1749683..1750087 (+) 405 WP_000878126.1 type II toxin-antitoxin system HicB family antitoxin -

Sequence

Protein


Download         Length: 814 a.a.        Molecular weight: 90682.41 Da        Isoelectric Point: 6.9323

>NTDB_id=309182 DZL40_RS08620 WP_011018294.1 1714453..1716897(-) (clpC) [Streptococcus pyogenes strain MGAS7914]
MIMYSTKMQDIFRQAQFQAARFDSHCLETWHVLLAMVAVDNSLANMILSEYDAQVAIEEYEAAAILAMGKTPKEQLSRVD
FRPQSKTLTNLLAFAQAISQITRDQEVGSEHVLFAILLNPDIMASRLLEIAGYQIKDNGNGQPRLADLRKAIERHAGYSK
EMIKAIHELRKPKKTKTQGTFSDMMKPPSTAGELSDFTRDLTEMARQGLLESVIGRDQEVSRMIQVLSRKTKNNPVLVGD
AGVGKTALAYGLAQRIANGAIPYELKEMRVLELDMMSVVAGTRFRGDFEERMNQIIDDIEADGQIILFVDELHTIMGSGS
GIDSTLDAANILKPALSRGTLHMVGATTQEEYQKHIEKDAALSRRFAKILIEEPNTEDAYQILMGLKLSYETYHNVSISN
EAVKTAVKMAHRYLTSKNLPDSAIDLLDEASAAVQNMVKKSAPETLTPIDQALINGDMKKVSRLLAKEAKGQMRKPTPVT
EDDILATLSKLSGIPLEKLTQADSKKYLNLEKELHKRVIGQDAAVTAISRAIRRNQSGIRTGKRPIGSFMFLGPTGVGKT
ELAKALAEVLFDDEAALIRFDMSEYMEKFAASRLNGAPPGYVGYDEGGELTQKVRNKPYSVLLFDEVEKAHPDIFNVLLQ
VLDDGILTDSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFGVKGIHQDHQAMEKRILEELRKTYRPEFINRIDEKVVFH
SLTQDNMRDVVKIMVQPLITTLAEKGITLKIQPLALKHLSEVGYDEHMGARPLRRTLQTEIEDKLSELILSRELTSGHTL
KIGLSYGKLTFHIA

Nucleotide


Download         Length: 2445 bp        

>NTDB_id=309182 DZL40_RS08620 WP_011018294.1 1714453..1716897(-) (clpC) [Streptococcus pyogenes strain MGAS7914]
ATGATTATGTATTCAACGAAGATGCAAGACATTTTTAGACAGGCGCAGTTCCAAGCTGCTCGCTTTGATAGCCATTGCCT
GGAAACTTGGCATGTTTTGTTAGCTATGGTAGCTGTAGATAATTCTTTAGCAAATATGATTTTAAGTGAATATGATGCCC
AAGTCGCCATAGAAGAATATGAAGCTGCAGCTATTTTAGCCATGGGCAAAACCCCTAAGGAACAGTTGTCTCGTGTAGAC
TTCAGACCTCAATCTAAAACCTTGACTAACTTGTTAGCTTTTGCGCAGGCTATTAGCCAAATCACTAGGGATCAAGAAGT
CGGCTCTGAGCATGTCTTATTTGCTATTTTATTGAATCCAGATATCATGGCGAGTCGTTTGTTAGAAATAGCAGGCTATC
AGATAAAAGATAACGGCAATGGGCAGCCGCGATTAGCTGACTTGCGAAAAGCAATAGAACGTCATGCAGGTTACAGTAAG
GAAATGATTAAGGCTATTCACGAACTACGTAAGCCTAAAAAAACGAAAACACAAGGGACCTTTTCAGATATGATGAAGCC
ACCAAGTACAGCTGGTGAATTGAGTGATTTCACAAGAGATTTGACTGAAATGGCAAGACAAGGTTTGTTAGAATCGGTGA
TTGGACGTGACCAAGAAGTATCTCGTATGATTCAGGTACTAAGTCGTAAAACGAAAAACAATCCTGTCTTGGTAGGTGAT
GCAGGTGTTGGTAAAACTGCGCTTGCTTATGGCCTTGCTCAACGGATTGCAAATGGCGCTATTCCTTATGAACTTAAGGA
GATGCGTGTCCTAGAATTAGACATGATGAGTGTGGTAGCAGGAACCCGTTTTCGTGGGGATTTTGAAGAGCGCATGAATC
AAATCATTGATGATATTGAAGCTGATGGTCAGATTATTCTTTTTGTTGATGAACTACATACTATTATGGGTTCTGGCAGT
GGTATTGACAGTACACTTGATGCGGCTAACATTTTAAAACCAGCATTATCGCGCGGTACTCTTCATATGGTTGGAGCAAC
AACTCAAGAAGAATATCAAAAACATATTGAAAAAGATGCAGCTCTTTCGCGTCGTTTTGCTAAAATATTAATTGAAGAAC
CTAATACAGAAGATGCTTATCAGATTTTGATGGGCCTAAAATTATCTTATGAGACCTACCATAATGTCTCGATATCAAAT
GAGGCAGTTAAAACAGCTGTAAAAATGGCACACCGTTATTTAACCAGTAAAAATCTCCCTGATTCAGCTATCGATTTATT
AGATGAAGCTAGTGCTGCTGTGCAAAACATGGTGAAAAAATCAGCTCCTGAGACTTTAACACCAATAGACCAAGCTCTTA
TCAATGGTGATATGAAAAAAGTATCTCGCCTCTTAGCTAAAGAAGCAAAAGGTCAGATGAGAAAACCAACACCAGTGACA
GAAGATGATATTTTGGCAACCTTGAGTAAGTTATCGGGAATTCCACTTGAAAAACTGACGCAAGCTGATAGTAAAAAATA
CCTCAATTTAGAAAAAGAACTGCATAAGCGTGTGATTGGTCAGGATGCTGCTGTTACGGCTATTTCAAGAGCCATTCGTC
GCAATCAGTCAGGTATTCGAACAGGAAAACGTCCTATTGGATCATTTATGTTTCTTGGCCCAACAGGAGTAGGTAAGACA
GAACTAGCAAAGGCCCTTGCAGAAGTTCTCTTTGATGATGAAGCAGCGCTTATTCGTTTTGATATGTCTGAGTACATGGA
AAAATTCGCAGCGTCTAGGCTTAATGGAGCACCTCCTGGTTATGTCGGCTATGATGAAGGAGGTGAACTGACACAGAAAG
TTAGAAATAAACCTTATTCAGTCTTGCTTTTTGATGAAGTGGAAAAAGCACATCCTGATATTTTTAACGTTCTCCTTCAA
GTATTAGATGATGGTATATTGACTGATAGTCGTGGGCGTAAGGTCGATTTTTCAAATACTATTATTATCATGACCAGCAA
TCTTGGCGCAACAGCCCTGCGTGATGATAAAACGGTCGGTTTTGGGGTCAAAGGCATTCACCAAGACCATCAAGCTATGG
AGAAACGTATTTTAGAAGAATTAAGAAAAACTTACCGCCCAGAATTTATCAATCGTATTGATGAAAAAGTGGTCTTTCAT
AGTCTGACCCAAGATAACATGCGCGATGTGGTTAAAATCATGGTACAGCCTCTGATTACTACATTGGCAGAAAAAGGTAT
TACCCTTAAAATTCAGCCTTTGGCCTTGAAACATTTGTCCGAGGTCGGCTATGATGAGCATATGGGGGCAAGACCATTAC
GTCGAACGCTGCAAACTGAGATAGAAGATAAGCTATCAGAGCTTATCCTTTCTCGAGAATTGACAAGTGGGCATACGCTA
AAAATTGGATTATCATATGGCAAATTAACGTTTCACATAGCTTAA

Domains

Predicted by InterproScan.

AAA domain (Cdc48 subfamily) (AAA_2)

(544-715)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(722-801)

AAA lid domain (AAA_lid_9)

(376-459)

Clp amino terminal domain, pathogenicity island component (Clp_N)

(95-130)

ATPase family associated with various cellular activities (AAA) (AAA)

(236-368)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Streptococcus mutans UA159

75.154

99.877

0.751
  clpC Streptococcus thermophilus LMG 18311

71.324

100

0.715
  clpC Streptococcus thermophilus LMD-9

71.201

100

0.714
  clpC Streptococcus pneumoniae TIGR4

65.971

100

0.66
  clpC Streptococcus pneumoniae Rx1

65.971

100

0.66
  clpC Streptococcus pneumoniae D39

65.971

100

0.66
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.852

100

0.493
  clpC Bacillus subtilis subsp. subtilis str. 168

42.326

100

0.434

Multiple sequence alignment