Detailed information NTG0309121

Bioinformatically predicted

Overview

• Name: vicK
• Type: Regulator
• Locus tag: DZM45_RS06950
• Genome accession: NZ_CP031638
• Coordinates: 1396710..1398062 (-)
• Length: 450 a.a.
• NCBI ID: WP_002995609.1
• Uniprot ID: A0A4U7GC27
• Organism: Streptococcus pyogenes strain MGAS8347
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1391710..1403062

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DZM45_RS06940 (DZM45_06935)	rnc	1394772..1395464 (-)	693	WP_011284596.1	ribonuclease III	-
DZM45_RS06945 (DZM45_06940)	vicX	1395897..1396706 (-)	810	WP_002985641.1	MBL fold metallo-hydrolase	Regulator
DZM45_RS06950 (DZM45_06945)	vicK	1396710..1398062 (-)	1353	WP_002995609.1	cell wall metabolism sensor histidine kinase VicK	Regulator
DZM45_RS06955 (DZM45_06950)	vicR	1398055..1398765 (-)	711	WP_002985645.1	response regulator YycF	Regulator
DZM45_RS06960 (DZM45_06955)	-	1398927..1399961 (-)	1035	WP_011284595.1	DUF3114 domain-containing protein	-
DZM45_RS06965 (DZM45_06960)	-	1400017..1401264 (-)	1248	WP_011284594.1	AMP-binding protein	-
DZM45_RS06970 (DZM45_06965)	-	1401221..1402369 (-)	1149	WP_011284593.1	acetyl-CoA C-acyltransferase	-
DZM45_RS06975 (DZM45_06970)	-	1402764..1402913 (-)	150	WP_002990686.1	hypothetical protein	-

Sequence

Protein

• Length: 450 a.a.
• Molecular weight: 51391.82 Da
• Isoelectric Point: 5.4026

>NTDB_id=309121 DZM45_RS06950 WP_002995609.1 1396710..1398062(-) (vicK) [Streptococcus pyogenes strain MGAS8347]
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRDLINGRYTDIIDEKADIELMELSDQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVYEIVRDYPITS
VWIEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD

Nucleotide

• Length: 1353 bp

>NTDB_id=309121 DZM45_RS06950 WP_002995609.1 1396710..1398062(-) (vicK) [Streptococcus pyogenes strain MGAS8347]
ATGACTAGAGATATCATTGGAAACTTATCCACATTTGAATTAGCGATCCTTATCTTACTTGTTTTTGTTGCTTTTTACTT
TATCCATCTTGCGGTGCGTGATTACCGAAATGCACGTATTATTCGGATGATGAGCCATAAAATCCGAGACTTGATTAATG
GTCGCTATACTGATATAATCGACGAAAAAGCAGACATTGAGTTAATGGAGCTTTCAGACCAGTTAAATGACCTATCAGAT
GTTTTTCGCTTGACGCATGAAAATCTTGCCCAAGAAAAAAATCGCTTGGCAAGTATTTTGGCTTATATGTCAGATGGTGT
ACTTGCTACAGACCGGTCTGGTAAAATCATCATGATTAACGAGACAGCTCGCAAGCAATTAAATTTAAGTAAAGAAGAGG
CACTAAAGAAAAACATTACAGATTTGTTAGAAGGTGATACTTCATATACCTACCGTGATTTGGTATCTAAAACACCAGTG
GTAACTGTTAATAGCCGAAATGATATGGGTGAGTTTGTCTCATTACGCTTGCGCTTTGCGTTGAATAGGAGAGAGAGTGG
TTTTATTTCGGGCTTGGTTGTGGTGCTCCATGACACCACAGAACAAGAAAAAGAAGAACGTGAACGCCGTCTTTTTGTCT
CTAATGTAAGTCATGAATTAAGGACCCCTTTAACTTCGGTTAAATCCTACTTGGAGGCTCTTGATGAAGGTGCACTTAAA
GAAGATATTGCTCCAAGTTTCATAAAAGTTTCTCTTGATGAAACTAATCGGATGATGCGTATGATTTCAGATCTTTTAAA
CCTGTCTCGGATTGATAATCAAGTAACCCAATTAGCAGTAGAGATGACTAATTTTACTGCTTTTATAACTTCTATTTTAA
ACAGATTTGATTTGGTTAAAAATCAGCATACAGGTACAGGAAAAGTCTATGAAATTGTAAGAGATTACCCTATTACCTCT
GTCTGGATTGAAATTGATAATGATAAAATGACACAGGTTATCGAGAATATTTTGAACAATGCCATTAAGTATTCTCCAGA
TGGTGGAAAAATCACAGTCCGTATGAAAACAACAGATACCCAATTAATTATTTCCATTTCAGACCAAGGACTAGGTATCC
CTAAAACAGATTTGCCTCTTATTTTTGATCGGTTCTATCGTGTAGACAAGGCAAGAAGTCGTGCCCAAGGAGGGACCGGT
CTAGGCCTTGCCATTGCTAAAGAAATCATCAAGCAGCACCATGGCTTTATCTGGGCTAAGAGTGACTATGGTAAAGGATC
GACCTTTACTATTGTCTTGCCTTATGAAAAAGATGCAGCCATCTATGAAGAATGGGAGGAAGATGTAGACTAA

Domains

Predicted by InterproScan.

• PAS fold (PAS) (95-162)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (326-436)

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

3D structure

• AlphaFold DB: A0A4U7GC27

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicK	Streptococcus mutans UA159	72.947	92	0.671
micB	Streptococcus pneumoniae Cp1015	67.765	94.444	0.64