Detailed information NTG0308272

Bioinformatically predicted

Overview

• Name: vicK
• Type: Regulator
• Locus tag: DZV70_RS07375
• Genome accession: NZ_CP031622
• Coordinates: 1443489..1444841 (-)
• Length: 450 a.a.
• NCBI ID: WP_002995609.1
• Uniprot ID: A0A4U7GC27
• Organism: Streptococcus pyogenes strain MGAS28686
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1438489..1449841

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DZV70_RS07365 (DZV70_07360)	rnc	1441551..1442243 (-)	693	WP_011284596.1	ribonuclease III	-
DZV70_RS07370 (DZV70_07365)	vicX	1442676..1443485 (-)	810	WP_002985641.1	MBL fold metallo-hydrolase	Regulator
DZV70_RS07375 (DZV70_07370)	vicK	1443489..1444841 (-)	1353	WP_002995609.1	cell wall metabolism sensor histidine kinase VicK	Regulator
DZV70_RS07380 (DZV70_07375)	vicR	1444834..1445544 (-)	711	WP_002985645.1	response regulator YycF	Regulator
DZV70_RS07385 (DZV70_07380)	-	1445706..1446740 (-)	1035	WP_011284595.1	DUF3114 domain-containing protein	-
DZV70_RS07390 (DZV70_07385)	-	1446796..1448043 (-)	1248	WP_011284594.1	AMP-binding protein	-
DZV70_RS07395 (DZV70_07390)	-	1448000..1449148 (-)	1149	WP_011284593.1	acetyl-CoA C-acyltransferase	-
DZV70_RS07400 (DZV70_07395)	-	1449543..1449692 (-)	150	WP_002990686.1	hypothetical protein	-

Sequence

Protein

• Length: 450 a.a.
• Molecular weight: 51391.82 Da
• Isoelectric Point: 5.4026

>NTDB_id=308272 DZV70_RS07375 WP_002995609.1 1443489..1444841(-) (vicK) [Streptococcus pyogenes strain MGAS28686]
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRDLINGRYTDIIDEKADIELMELSDQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVYEIVRDYPITS
VWIEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD

Nucleotide

• Length: 1353 bp

>NTDB_id=308272 DZV70_RS07375 WP_002995609.1 1443489..1444841(-) (vicK) [Streptococcus pyogenes strain MGAS28686]
ATGACTAGAGATATCATTGGAAACTTATCCACATTTGAATTAGCGATCCTTATCTTACTTGTTTTTGTTGCTTTTTACTT
TATCCATCTTGCGGTGCGTGATTACCGAAATGCACGTATTATTCGGATGATGAGCCATAAAATCCGAGACTTGATTAATG
GTCGCTATACTGATATAATCGACGAAAAAGCAGACATTGAGTTAATGGAGCTTTCAGACCAGTTAAATGACCTATCAGAT
GTTTTTCGCTTGACGCATGAAAATCTTGCCCAAGAAAAAAATCGCTTGGCAAGTATTTTGGCTTATATGTCAGATGGTGT
ACTTGCTACAGACCGGTCTGGTAAAATCATCATGATTAACGAGACAGCTCGCAAGCAATTAAATTTAAGTAAAGAAGAGG
CACTAAAGAAAAACATTACAGATTTGTTAGAAGGTGATACTTCATATACCTACCGTGATTTGGTATCTAAAACACCAGTG
GTAACTGTTAATAGCCGAAATGATATGGGTGAGTTTGTCTCATTACGCTTGCGCTTTGCGTTGAATAGGAGAGAGAGTGG
TTTTATTTCGGGCTTGGTTGTGGTGCTCCATGACACCACAGAACAAGAAAAAGAAGAACGTGAACGCCGTCTTTTTGTCT
CTAATGTAAGTCATGAATTAAGGACCCCTTTAACTTCGGTTAAATCCTACTTGGAGGCTCTTGATGAAGGTGCACTTAAA
GAAGATATTGCTCCAAGTTTCATAAAAGTTTCTCTTGATGAAACTAATCGGATGATGCGTATGATTTCAGATCTTTTAAA
CCTGTCTCGGATTGATAATCAAGTAACCCAATTAGCAGTAGAGATGACTAATTTTACTGCTTTTATAACTTCTATTTTAA
ACAGATTTGATTTGGTTAAAAATCAGCATACAGGTACAGGAAAAGTCTATGAAATTGTAAGAGATTACCCTATTACCTCT
GTCTGGATTGAAATTGATAATGATAAAATGACACAGGTTATCGAGAATATTTTGAACAATGCCATTAAGTATTCTCCAGA
TGGTGGAAAAATCACAGTCCGTATGAAAACAACAGATACCCAATTAATTATTTCCATTTCAGACCAAGGACTAGGTATCC
CTAAAACAGATTTGCCTCTTATTTTTGATCGGTTCTATCGTGTAGACAAGGCAAGAAGTCGTGCCCAAGGAGGGACCGGT
CTAGGCCTTGCCATTGCTAAAGAAATCATCAAGCAGCACCATGGCTTTATCTGGGCTAAGAGTGACTATGGTAAAGGATC
GACCTTTACTATTGTCTTGCCTTATGAAAAAGATGCAGCCATCTATGAAGAATGGGAGGAAGATGTAGACTAA

Domains

Predicted by InterproScan.

• PAS fold (PAS) (95-162)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (326-436)

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

3D structure

• AlphaFold DB: A0A4U7GC27

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicK	Streptococcus mutans UA159	72.947	92	0.671
micB	Streptococcus pneumoniae Cp1015	67.765	94.444	0.64