Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpX   Type   Regulator
Locus tag   DZW30_RS05845 Genome accession   NZ_CP031621
Coordinates   1142941..1144170 (-) Length   409 a.a.
NCBI ID   WP_002984948.1    Uniprot ID   A0A4U7GJW1
Organism   Streptococcus pyogenes strain MGAS28746     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1137941..1149170
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DZW30_RS05825 (DZW30_05825) rpiA 1138224..1138907 (-) 684 WP_011284704.1 ribose-5-phosphate isomerase RpiA -
  DZW30_RS05830 (DZW30_05830) - 1139285..1141384 (+) 2100 WP_011284703.1 ATP-dependent Clp protease ATP-binding subunit -
  DZW30_RS05835 (DZW30_05835) - 1141459..1142184 (-) 726 Protein_1068 hypothetical protein -
  DZW30_RS05840 (DZW30_05840) yihA 1142332..1142931 (-) 600 WP_011284702.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
  DZW30_RS05845 (DZW30_05845) clpX 1142941..1144170 (-) 1230 WP_002984948.1 ATP-dependent Clp protease ATP-binding subunit ClpX Regulator
  DZW30_RS05850 (DZW30_05850) - 1144300..1144470 (-) 171 WP_002990165.1 hypothetical protein -
  DZW30_RS05855 (DZW30_05855) - 1144490..1144987 (-) 498 WP_011284701.1 dihydrofolate reductase -
  DZW30_RS05860 (DZW30_05860) - 1145067..1145906 (-) 840 WP_011017679.1 thymidylate synthase -
  DZW30_RS05865 (DZW30_05865) - 1146115..1147290 (+) 1176 WP_021340971.1 hydroxymethylglutaryl-CoA synthase -
  DZW30_RS05870 (DZW30_05870) - 1147277..1148554 (+) 1278 WP_011284699.1 hydroxymethylglutaryl-CoA reductase, degradative -

Sequence

Protein


Download         Length: 409 a.a.        Molecular weight: 44991.44 Da        Isoelectric Point: 4.5775

>NTDB_id=308212 DZW30_RS05845 WP_002984948.1 1142941..1144170(-) (clpX) [Streptococcus pyogenes strain MGAS28746]
MAGSRTNDIKVYCSFCGKSQDDVKKIIAGNNVFICNECVALSQEIIKEELAEEVLADLTEVPKPKELLDVLNQYVVGQDR
AKRALSVAVYNHYKRVSFTESRDDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEEIVKQRLGEKVIGFGQNSRKIDDNASYMQEIISEDIQKFGLIPEFIGRLPVVAALEQLNTSDLIQI
LTEPRNALVKQYQALLSYDGVELAFDKEALEAIANKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVTKVRITKAAVEG
KSKPVLETA

Nucleotide


Download         Length: 1230 bp        

>NTDB_id=308212 DZW30_RS05845 WP_002984948.1 1142941..1144170(-) (clpX) [Streptococcus pyogenes strain MGAS28746]
ATGGCAGGAAGTAGAACTAACGATATTAAAGTATACTGTTCATTTTGTGGTAAAAGCCAGGATGACGTTAAAAAAATTAT
CGCAGGAAATAATGTTTTCATCTGCAATGAATGCGTAGCTTTATCACAAGAAATTATAAAAGAAGAATTGGCTGAAGAAG
TCCTTGCCGATTTGACAGAAGTTCCAAAACCAAAAGAGCTCCTTGATGTTTTAAATCAATATGTGGTTGGTCAAGATCGT
GCTAAACGTGCTTTATCAGTTGCTGTGTACAATCATTATAAGCGTGTCTCGTTTACAGAAAGTCGTGATGACGATGATGT
GGATTTACAAAAGTCCAACATTTTGATGATTGGACCAACAGGTTCAGGAAAAACCTTCTTAGCACAAACTCTGGCTAAAA
GCCTCAATGTACCATTTGCTATTGCAGATGCAACTTCTTTGACTGAAGCAGGGTATGTTGGAGAAGATGTGGAAAATATT
TTACTCAAACTGATTCAGGCTGCTGACTATAATGTCGAACGAGCAGAGCGTGGTATTATTTATGTTGATGAAATAGATAA
GATTGCTAAAAAAGGTGAGAACGTATCTATCACACGTGATGTATCTGGTGAAGGTGTACAGCAAGCCCTTCTTAAAATTA
TTGAAGGTACGGTAGCAAGTGTTCCCCCACAAGGTGGGCGGAAGCACCCTAATCAAGAAATGATCCAAATTGATACAAAA
AATATCTTGTTTATTGTTGGCGGGGCTTTTGATGGCATCGAGGAGATTGTTAAACAACGTTTAGGTGAAAAAGTTATTGG
TTTTGGTCAAAACAGCCGTAAAATTGATGACAATGCTTCTTATATGCAAGAAATTATTTCAGAAGATATTCAAAAGTTTG
GGCTTATTCCAGAATTTATTGGCCGCTTACCAGTTGTGGCAGCCCTTGAACAACTAAACACATCAGATTTGATTCAAATT
TTGACAGAACCAAGAAATGCCCTGGTCAAGCAATATCAGGCCCTTCTTTCTTACGATGGCGTCGAATTGGCATTTGATAA
GGAAGCCTTAGAAGCCATTGCCAATAAAGCCATTGAGCGTAAGACAGGAGCACGTGGTCTTCGTTCTATTATTGAAGAAA
CGATGTTAGACATTATGTTTGAAATTCCAAGCCAAGAAGATGTCACAAAAGTGCGTATCACCAAGGCTGCTGTCGAAGGC
AAGTCAAAACCCGTTTTAGAGACAGCTTAA

Domains

Predicted by InterproScan.

AAA domain (Cdc48 subfamily) (AAA_2)

(110-305)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(312-391)

ClpX C4-type zinc finger (zf-C4_ClpX)

(12-48)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4U7GJW1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpX Streptococcus mutans UA159

88.998

100

0.89
  clpX Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.603

98.044

0.575

Multiple sequence alignment