Detailed information NTG0306334

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: EW997_RS21290
• Genome accession: NZ_CP035879
• Coordinates: 4294425..4296998 (+)
• Length: 857 a.a.
• NCBI ID: WP_001235102.1
• Uniprot ID: P63286
• Organism: Escherichia coli strain DS26-1
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 4289425..4301998

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EW997_RS21260	pheA	4289693..4290853 (-)	1161	WP_000200100.1	bifunctional chorismate mutase/prephenate dehydratase	-
EW997_RS21265	pheL	4290952..4290999 (-)	48	WP_001700969.1	pheA operon leader peptide PheL	-
EW997_RS21270	raiA	4291103..4291444 (-)	342	WP_000178456.1	ribosome-associated translation inhibitor RaiA	-
EW997_RS21275	comL	4291715..4292452 (-)	738	WP_000197686.1	outer membrane protein assembly factor BamD	Machinery gene
EW997_RS21280	rluD	4292587..4293567 (+)	981	WP_000079100.1	23S rRNA pseudouridine(1911/1915/1917) synthase RluD	-
EW997_RS21285	yfiH	4293564..4294295 (+)	732	WP_000040129.1	purine nucleoside phosphorylase YfiH	-
EW997_RS21290	clpC	4294425..4296998 (+)	2574	WP_001235102.1	ATP-dependent chaperone ClpB	Regulator

Sequence

Protein

• Length: 857 a.a.
• Molecular weight: 95585.02 Da
• Isoelectric Point: 5.1899

>NTDB_id=306334 EW997_RS21290 WP_001235102.1 4294425..4296998(+) (clpC) [Escherichia coli strain DS26-1]
MRLDRLTNKFQLALADAQSLALGHDNQFIEPLHLMSALLNQEGGSVSPLLTSAGINAGQLRTDINQALNRLPQVEGTGGD
VQPSQDLVRVLNLCDKLAQKRGDNFISSELFVLAALESRGTLADILKAAGATTANITQAIEQMRGGESVNDQGAEDQRQA
LKKYTIDLTERAEQGKLDPVIGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKGRRVLAL
DMGALVAGAKYRGEFEERLKGVLNDLAKQEGNVILFIDELHTMVGAGKADGAMDAGNMLKPALARGELHCVGATTLDEYR
QYIEKDAALERRFQKVFVAEPSVEDTIAILRGLKERYELHHHVQITDPAIVAAATLSHRYIADRQLPDKAIDLIDEAASS
IRMQIDSKPEELDRLDRRIIQLKLEQQALMKESDEASKKRLDMLNEELSDKERQYSELEEEWKAEKASLSGTQTIKAELE
QAKIAIEQARRVGDLARMSELQYGKIPELEKQLEAATQLEGKTMRLLRNKVTDAEIAEVLARWTGIPVSRMMESEREKLL
RMEQELHHRVIGQNEAVDAVSNAIRRSRAGLADPNRPIGSFLFLGPTGVGKTELCKALANFMFDSDEAMVRIDMSEFMEK
HSVSRLVGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNL
GSDLIQERFGELDYAHMKELVLGVVSHNFRPEFINRIDEVVVFHPLGEQHIASIAQIQLKRLYKRLEERGYEIHISDEAL
KLLSENGYDPVYGARPLKRAIQQQIENPLAQQILSGELVPGKVIRLEVNEDRIVAVQ

Nucleotide

• Length: 2574 bp

>NTDB_id=306334 EW997_RS21290 WP_001235102.1 4294425..4296998(+) (clpC) [Escherichia coli strain DS26-1]
ATGCGTCTGGATCGTCTTACTAATAAATTCCAGCTTGCTCTTGCCGATGCCCAATCACTTGCACTCGGGCACGACAACCA
ATTCATCGAACCACTTCATTTAATGAGCGCCCTGCTGAATCAGGAAGGGGGTTCGGTTAGTCCTTTGTTAACATCAGCTG
GCATAAATGCTGGCCAGTTGCGCACAGATATCAATCAGGCATTAAATCGTTTACCGCAGGTTGAAGGTACTGGTGGTGAT
GTCCAGCCATCACAGGATCTGGTGCGCGTTCTTAATCTTTGCGACAAGCTGGCGCAAAAACGTGGTGATAACTTTATCTC
GTCAGAACTGTTCGTTCTGGCGGCACTTGAGTCTCGCGGCACGCTGGCCGACATCCTGAAAGCAGCAGGGGCGACCACCG
CCAACATTACTCAAGCGATTGAACAAATGCGTGGAGGTGAAAGCGTGAACGATCAAGGTGCTGAAGACCAACGTCAGGCT
TTGAAAAAATATACCATCGACCTTACCGAACGAGCCGAACAGGGCAAACTCGATCCGGTGATTGGTCGTGATGAAGAAAT
TCGCCGTACCATTCAGGTGCTGCAACGTCGTACTAAAAATAACCCGGTACTGATTGGTGAACCCGGCGTCGGTAAAACTG
CCATCGTTGAAGGTCTGGCGCAGCGTATTATCAACGGCGAAGTGCCGGAAGGATTGAAAGGCCGCCGCGTACTGGCGCTG
GATATGGGCGCGCTGGTGGCTGGGGCGAAATATCGCGGTGAGTTTGAAGAACGTTTAAAAGGCGTGCTTAACGATCTTGC
CAAACAGGAAGGCAACGTCATCCTGTTTATCGACGAATTACATACCATGGTCGGCGCGGGTAAAGCCGATGGCGCAATGG
ACGCCGGAAACATGCTGAAACCGGCGCTGGCGCGTGGTGAATTGCACTGCGTAGGTGCCACGACGCTTGACGAATATCGC
CAGTACATCGAAAAAGATGCTGCGCTGGAACGTCGTTTCCAGAAAGTGTTTGTTGCCGAGCCTTCTGTTGAAGATACCAT
TGCGATTCTGCGTGGCCTGAAAGAACGTTACGAATTGCACCACCATGTGCAAATTACTGACCCGGCAATTGTTGCAGCGG
CGACGTTGTCTCATCGCTACATTGCTGACCGTCAGCTGCCGGATAAAGCCATCGACCTGATCGATGAAGCAGCATCCAGC
ATTCGTATGCAGATTGACTCAAAACCAGAAGAACTCGACCGACTCGATCGTCGTATCATCCAGCTCAAACTGGAACAACA
GGCGTTAATGAAAGAGTCTGATGAAGCCAGTAAAAAACGCCTGGATATGCTCAACGAAGAACTGAGCGACAAAGAACGTC
AGTACTCCGAGTTAGAAGAAGAGTGGAAAGCAGAGAAGGCATCGCTTTCTGGTACGCAGACCATTAAAGCGGAACTGGAA
CAGGCGAAAATCGCTATTGAACAGGCTCGCCGTGTGGGGGACCTGGCGCGGATGTCTGAACTGCAATACGGCAAAATCCC
GGAACTGGAAAAGCAACTGGAAGCCGCAACGCAGCTCGAAGGCAAAACTATGCGTCTGTTGCGTAATAAAGTGACCGACG
CCGAAATTGCTGAAGTGCTGGCGCGTTGGACGGGGATTCCGGTTTCTCGCATGATGGAAAGCGAGCGCGAAAAACTGCTG
CGTATGGAGCAAGAACTGCACCATCGCGTCATTGGTCAGAACGAAGCGGTTGATGCGGTATCTAACGCTATTCGCCGTAG
CCGTGCGGGGTTGGCGGATCCAAATCGCCCGATTGGTTCATTCCTGTTCCTCGGCCCAACGGGTGTGGGGAAAACAGAGC
TTTGTAAGGCGCTGGCGAACTTTATGTTTGATAGCGACGAGGCGATGGTCCGTATAGATATGTCCGAGTTTATGGAGAAA
CACTCGGTGTCTCGTTTGGTTGGTGCGCCTCCGGGATATGTCGGTTATGAAGAAGGTGGCTACCTGACCGAAGCGGTGCG
TCGTCGTCCGTATTCCGTCATCCTGCTGGATGAAGTGGAAAAAGCGCATCCGGATGTCTTCAACATTCTGTTGCAGGTAC
TGGATGATGGGCGTCTGACTGACGGGCAGGGGAGAACGGTCGACTTCCGTAATACGGTCGTCATTATGACCTCTAACCTC
GGTTCCGATCTGATTCAGGAACGCTTCGGTGAACTGGATTATGCGCACATGAAAGAGCTGGTGCTCGGTGTGGTTAGCCA
TAACTTCCGTCCGGAATTCATTAACCGTATCGATGAAGTGGTGGTCTTCCATCCGCTGGGTGAACAGCACATTGCGTCGA
TTGCGCAGATTCAGTTGAAACGTCTGTATAAACGTCTGGAAGAACGTGGTTATGAAATCCACATTTCTGACGAGGCGCTG
AAACTGCTGAGCGAGAACGGTTACGATCCGGTCTATGGTGCACGTCCTCTGAAACGTGCAATTCAGCAGCAGATCGAAAA
CCCGCTGGCACAGCAAATACTGTCTGGTGAATTGGTTCCGGGTAAAGTGATTCGCCTGGAAGTTAATGAAGACCGGATTG
TCGCCGTCCAGTAA

Domains

Predicted by InterProScan.

• AAA lid domain (AAA_lid_9) (342-443)

• ATPase family associated with various cellular activities (AAA) (AAA) (203-337)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (94-145)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (17-68)

• AAA domain (Cdc48 subfamily) (AAA_2) (596-760)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (766-845)

3D structure

• AlphaFold DB: P63286

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	47.816	100	0.485
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	42.575	100	0.428
clpE	Streptococcus pneumoniae Rx1	47.865	79.23	0.379
clpE	Streptococcus pneumoniae D39	47.865	79.23	0.379
clpE	Streptococcus pneumoniae R6	47.865	79.23	0.379
clpE	Streptococcus pneumoniae TIGR4	47.865	79.23	0.379
clpC	Lactococcus lactis subsp. cremoris KW2	46.377	80.513	0.373
clpE	Streptococcus mutans UA159	46.491	79.813	0.371