Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Machinery gene
Locus tag   DV144_RS13290 Genome accession   NZ_CP031328
Coordinates   399696..400160 (+) Length   154 a.a.
NCBI ID   WP_162818857.1    Uniprot ID   -
Organism   Neisseria meningitidis strain M18755     
Function   DNA binding (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 399861..421028 399696..400160 flank -299
IScluster/Tn 400432..401933 399696..400160 flank 272


Gene organization within MGE regions


Location: 399696..421028
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DV144_RS13290 comE 399696..400160 (+) 465 WP_162818857.1 ComEA family DNA-binding protein Machinery gene
  DV144_RS02480 - 400231..401196 (-) 966 Protein_390 IS30-like element IS1655 family transposase -
  DV144_RS02485 - 401291..401933 (-) 643 Protein_391 IS1595 family transposase -
  DV144_RS02490 dnaJ 402261..403382 (+) 1122 WP_002218502.1 molecular chaperone DnaJ -
  DV144_RS02495 - 403578..405596 (+) 2019 WP_115430700.1 oligopeptide transporter, OPT family -
  DV144_RS02500 rfbC 405640..406197 (-) 558 WP_115430701.1 dTDP-4-dehydrorhamnose 3,5-epimerase -
  DV144_RS02505 rfbA 406242..407108 (-) 867 WP_002259283.1 glucose-1-phosphate thymidylyltransferase RfbA -
  DV144_RS02510 rffG 407171..408253 (-) 1083 WP_002238588.1 dTDP-glucose 4,6-dehydratase -
  DV144_RS13955 galE 408254..408874 (-) 621 Protein_397 UDP-glucose 4-epimerase GalE -
  DV144_RS13960 - 408953..409297 (-) 345 WP_002231447.1 DNA adenine methylase -
  DV144_RS14235 - 409290..409484 (-) 195 WP_002215282.1 DNA cytosine methyltransferase -
  DV144_RS02520 dcm 409462..410292 (-) 831 WP_002215283.1 DNA (cytosine-5-)-methyltransferase -
  DV144_RS02525 - 410323..412596 (-) 2274 WP_115430702.1 Tex family protein -
  DV144_RS02530 - 412660..413310 (-) 651 WP_002256274.1 ABC transporter ATP-binding protein -
  DV144_RS02535 - 413307..414104 (-) 798 WP_002215286.1 ABC transporter permease -
  DV144_RS02540 ctrB 414104..415267 (-) 1164 WP_002248588.1 capsule polysaccharide export protein CtrB -
  DV144_RS02545 ctrA 415282..416457 (-) 1176 WP_002215290.1 capsule polysaccharide export outer membrane protein CtrA -
  DV144_RS02550 neuC 416584..417717 (+) 1134 WP_115430886.1 UDP-N-acetylglucosamine 2-epimerase -
  DV144_RS02555 neuA 417721..418407 (+) 687 WP_002215295.1 N-acylneuraminate cytidylyltransferase -
  DV144_RS02560 siaC 418408..419457 (+) 1050 WP_002215299.1 polysialic acid capsule biosynthesis protein SiaC -
  DV144_RS02565 - 419541..421028 (+) 1488 WP_002215303.1 alpha-2,8-polysialyltransferase family protein -

Sequence

Protein


Download         Length: 154 a.a.        Molecular weight: 16606.87 Da        Isoelectric Point: 10.8773

>NTDB_id=305760 DV144_RS13290 WP_162818857.1 399696..400160(+) (comE) [Neisseria meningitidis strain M18755]
MLYPEKMSGMAGRHPYGVRSGLRRNGLKLWDIHFRMTRFIVARCGLLFATLKGKTMKKMFVLFCMLFSCTFSLAAVNINA
ASLQELEALPGIGPAKAKAIAEYRAQNGAFKSVDDLTKVKGIGPAVLAKLKDQASVGAPAPKGPAKPVLPADKK

Nucleotide


Download         Length: 465 bp        

>NTDB_id=305760 DV144_RS13290 WP_162818857.1 399696..400160(+) (comE) [Neisseria meningitidis strain M18755]
TTGCTTTACCCGGAAAAAATGTCGGGGATGGCGGGACGGCATCCGTACGGCGTCCGGTCGGGTTTGCGGAGGAACGGCTT
GAAACTTTGGGATATTCATTTTAGAATGACTCGTTTTATCGTCGCAAGATGCGGTTTATTGTTTGCAACCCTTAAAGGAA
AAACCATGAAGAAAATGTTCGTGCTGTTCTGTATGCTGTTCTCCTGCACCTTCTCCCTTGCGGCGGTAAACATCAATGCG
GCTTCGCTGCAGGAGTTGGAGGCGCTGCCGGGCATAGGTCCGGCGAAGGCGAAGGCCATTGCGGAATACCGTGCGCAAAA
CGGTGCGTTCAAGTCTGTGGACGATTTGACCAAGGTAAAGGGCATCGGCCCTGCGGTGCTGGCGAAGCTGAAGGATCAGG
CTTCCGTCGGCGCACCCGCACCAAAAGGCCCAGCTAAACCAGTGCTGCCCGCGGATAAAAAATAA

Domains

Predicted by InterproScan.

Helix-hairpin-helix motif (HHH_3)

(75-133)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Neisseria gonorrhoeae MS11

92.623

79.221

0.734
  comE Neisseria gonorrhoeae MS11

92.623

79.221

0.734
  comE Neisseria gonorrhoeae MS11

92.623

79.221

0.734
  comE Neisseria gonorrhoeae MS11

92.623

79.221

0.734

Multiple sequence alignment