Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   EW647_RS12815 Genome accession   NZ_CP035767
Coordinates   2466470..2467126 (-) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli O145 strain RM12522-C8     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2461470..2472126
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EW647_RS12775 (EW647_13225) - 2461982..2462242 (+) 261 WP_000488107.1 ogr/Delta-like zinc finger family protein -
  EW647_RS12780 (EW647_13230) - 2462432..2462572 (+) 141 WP_000078920.1 Hok/Gef family protein -
  EW647_RS12785 (EW647_13235) - 2462761..2463042 (-) 282 WP_071529678.1 hypothetical protein -
  EW647_RS12805 (EW647_13255) pgsA 2464036..2464584 (-) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  EW647_RS12810 (EW647_13260) uvrC 2464641..2466473 (-) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  EW647_RS12815 (EW647_13265) letA 2466470..2467126 (-) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  EW647_RS12820 (EW647_13270) yecU 2467422..2467598 (+) 177 WP_001307856.1 protein YecU -
  EW647_RS12825 (EW647_13275) yecF 2467585..2467809 (+) 225 WP_000106476.1 DUF2594 family protein YecF -
  EW647_RS12830 (EW647_13280) sdiA 2467877..2468599 (-) 723 WP_001154283.1 transcriptional regulator SdiA -
  EW647_RS12835 (EW647_13285) tcyN 2468829..2469581 (-) 753 WP_001272991.1 L-cystine ABC transporter ATP-binding protein TcyN -
  EW647_RS12840 (EW647_13290) tcyL 2469578..2470246 (-) 669 WP_001158220.1 cystine ABC transporter permease -
  EW647_RS12845 (EW647_13295) dcyD 2470261..2471247 (-) 987 WP_001128215.1 D-cysteine desulfhydrase -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=304655 EW647_RS12815 WP_000611328.1 2466470..2467126(-) (letA) [Escherichia coli O145 strain RM12522-C8]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=304655 EW647_RS12815 WP_000611328.1 2466470..2467126(-) (letA) [Escherichia coli O145 strain RM12522-C8]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGCCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATCCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482