Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   ETT44_RS08950 Genome accession   NZ_CP035455
Coordinates   1730522..1732504 (-) Length   660 a.a.
NCBI ID   WP_002992189.1    Uniprot ID   P0DC59
Organism   Streptococcus pyogenes strain emm197     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1725522..1737504
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT44_RS08925 (ETT44_08915) recA 1725558..1726694 (-) 1137 WP_002982186.1 recombinase RecA Machinery gene
  ETT44_RS08930 (ETT44_08920) cinA 1726783..1728054 (-) 1272 WP_115346619.1 competence/damage-inducible protein A Machinery gene
  ETT44_RS08935 (ETT44_08925) - 1728123..1728683 (-) 561 WP_136021841.1 DNA-3-methyladenine glycosylase I -
  ETT44_RS08940 (ETT44_08930) ruvA 1728693..1729289 (-) 597 WP_002992186.1 Holliday junction branch migration protein RuvA Machinery gene
  ETT44_RS08945 (ETT44_08935) - 1729291..1730511 (-) 1221 WP_002992187.1 MFS transporter -
  ETT44_RS08950 (ETT44_08940) hexB 1730522..1732504 (-) 1983 WP_002992189.1 DNA mismatch repair endonuclease MutL Machinery gene
  ETT44_RS08955 (ETT44_08945) hexA 1732633..1735188 (-) 2556 WP_021734054.1 DNA mismatch repair protein MutS Machinery gene
  ETT44_RS09530 (ETT44_08950) - 1735175..1735381 (-) 207 WP_002982173.1 hypothetical protein -
  ETT44_RS08965 (ETT44_08955) argR 1735524..1735961 (-) 438 WP_002993102.1 arginine repressor -

Sequence

Protein


Download         Length: 660 a.a.        Molecular weight: 74419.99 Da        Isoelectric Point: 5.7605

>NTDB_id=303603 ETT44_RS08950 WP_002992189.1 1730522..1732504(-) (hexB) [Streptococcus pyogenes strain emm197]
MTNIIELPEVLANQIAAGEVVERPASVVKELVENAIDAKSSQITVEIEESGLKMIQVTDNGEGMSHEDLPLSLRRHATSK
IKSQSDLFRIRTLGFRGEALPSVASISKITIKTATKEVTHGSLLIATGGEIETLEAISTPTGTKIKVENLFYNTPARLKY
MKSLQAELAHIVDVVNRLSLAHPEVAFTLISDGRQLTQTSGTGDLRQAIAGIYGLNTTKKMLAISNADLDFEVSGYVSLP
ELTRANRNYMTILVNGRYIKNFLLNRAILDGYGSKLMVGRFPIVVIDIQIDPYLADVNVHPTKQEVRISKERELMALIST
AISESLKEQDLIPDALENLAKSSTRHFSKPEQTQLPLQSRGLYYDPQKNDFFVKESAVSEKIPETDFYFGTVDNSVKVEK
AELLPHSEEVIGPSSVKHASRPQNTFTETDHPNLDLKNRQKLSQMLTRLENEEQSVFPELDYFGQMHGTYLFAQGKDGLF
IIDQHAAQERVKYEYYRDKIGEVDSSLQQLLVPYLFEFSGSDFINLQEKMALLNEVGIFLEVYGHNTFILREHPIWMKEE
EIASGVYEMCDMLLLTNEVSIKTYRAELAIMMSCKRSIKANHSLDDYSARNLLLQLAQCQNPYNCPHGRPVLINFSKADM
EKMFRRIQENHTSLRELGKY

Nucleotide


Download         Length: 1983 bp        

>NTDB_id=303603 ETT44_RS08950 WP_002992189.1 1730522..1732504(-) (hexB) [Streptococcus pyogenes strain emm197]
ATGACAAACATTATTGAATTACCGGAAGTTCTCGCCAACCAAATTGCAGCTGGTGAAGTTGTAGAAAGGCCAGCGAGTGT
TGTCAAGGAATTGGTTGAGAATGCTATTGATGCTAAAAGTAGCCAGATTACCGTTGAAATTGAAGAGTCTGGCCTTAAGA
TGATACAGGTTACAGACAACGGTGAGGGAATGTCTCATGAAGATTTACCTTTAAGTCTGCGTCGCCACGCTACTAGTAAA
ATTAAGAGTCAGAGTGATTTGTTTAGAATTAGAACACTTGGCTTCCGTGGAGAGGCTTTACCGTCTGTTGCCTCTATCAG
TAAAATCACGATAAAAACAGCAACAAAAGAAGTCACTCACGGTTCTCTTCTTATAGCTACTGGTGGGGAAATTGAGACAC
TTGAAGCGATCTCAACTCCTACTGGAACCAAAATTAAGGTTGAAAACCTTTTTTACAACACGCCTGCTCGTCTCAAATAC
ATGAAAAGTTTACAGGCAGAATTAGCTCACATTGTAGATGTGGTCAACCGGTTGAGTTTGGCACATCCAGAAGTTGCTTT
CACACTGATTAGTGATGGTCGCCAATTAACTCAGACATCAGGAACTGGCGATTTACGCCAAGCAATTGCAGGGATTTATG
GTTTGAATACTACCAAAAAAATGCTGGCTATCTCTAATGCTGATTTGGATTTTGAAGTTTCCGGCTATGTTAGCTTGCCA
GAGTTGACACGCGCCAACCGTAATTACATGACGATTTTGGTTAATGGGCGTTATATCAAGAATTTCTTGCTTAATCGAGC
AATTCTTGATGGTTACGGTTCTAAGCTCATGGTTGGACGTTTCCCAATTGTTGTGATTGATATTCAGATTGATCCCTATT
TGGCCGATGTCAATGTTCATCCCACAAAACAAGAGGTTCGTATTTCAAAAGAGCGTGAGTTGATGGCTTTAATTAGTACG
GCGATTTCTGAAAGTCTTAAGGAACAAGATTTGATTCCAGATGCTCTGGAAAACTTAGCCAAATCAAGCACACGACATTT
CTCTAAACCAGAGCAAACACAACTTCCTTTACAGTCTAGGGGACTTTATTATGATCCTCAAAAGAATGACTTTTTTGTCA
AAGAGTCGGCTGTCTCGGAAAAAATACCTGAAACTGATTTTTATTTCGGCACTGTTGACAACAGTGTAAAGGTTGAAAAA
GCAGAGCTGTTACCCCACTCAGAAGAAGTTATAGGACCTTCTTCGGTTAAACACGCAAGTCGTCCCCAGAATACCTTTAC
CGAGACTGATCATCCTAATCTTGACTTAAAAAACAGACAAAAGTTATCTCAAATGCTAACCCGTTTGGAAAATGAAGAGC
AATCAGTGTTTCCCGAATTGGATTATTTTGGTCAGATGCACGGAACTTATCTCTTTGCTCAGGGAAAAGATGGTTTATTT
ATAATTGACCAACACGCTGCCCAGGAGCGGGTTAAATACGAATATTATCGTGATAAGATTGGTGAGGTTGACAGTAGTTT
ACAGCAATTGTTGGTGCCCTATTTGTTTGAGTTTTCTGGTTCTGATTTCATTAACTTACAGGAGAAAATGGCACTCTTAA
ATGAAGTTGGTATCTTCTTAGAAGTTTATGGGCACAATACTTTCATTTTGAGGGAGCATCCTATCTGGATGAAAGAAGAA
GAGATTGCATCTGGTGTCTATGAAATGTGTGACATGTTACTTCTAACCAATGAGGTATCTATTAAAACTTACCGAGCAGA
GTTAGCTATTATGATGAGTTGTAAACGATCTATCAAGGCAAATCATAGCTTGGATGATTATTCAGCAAGAAATCTGCTAC
TGCAATTGGCCCAATGTCAAAATCCTTATAACTGCCCTCATGGTAGACCCGTATTGATTAATTTTAGTAAGGCAGATATG
GAAAAAATGTTCCGTCGAATTCAAGAAAATCACACTAGCCTGCGAGAGCTAGGAAAATATTAG

Domains

Predicted by InterProScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-118)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

MutL C terminal dimerisation domain (MutL_C)

(462-604)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P0DC59

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

66.867

100

0.676