Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   ETT44_RS02890 Genome accession   NZ_CP035455
Coordinates   538252..538893 (+) Length   213 a.a.
NCBI ID   WP_136021932.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm197     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 533252..543893
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT44_RS02870 (ETT44_02870) - 533808..534548 (+) 741 WP_136021933.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  ETT44_RS02875 (ETT44_02875) pknB 534545..536443 (+) 1899 WP_002994648.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  ETT44_RS02880 (ETT44_02880) liaF 536566..537258 (+) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  ETT44_RS02885 (ETT44_02885) - 537255..538259 (+) 1005 WP_002991890.1 sensor histidine kinase -
  ETT44_RS02890 (ETT44_02890) vraR 538252..538893 (+) 642 WP_136021932.1 response regulator transcription factor Regulator
  ETT44_RS02895 (ETT44_02895) - 538930..540330 (+) 1401 WP_011054832.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  ETT44_RS02900 (ETT44_02900) - 540330..540707 (+) 378 WP_002991882.1 S1 RNA-binding domain-containing protein -
  ETT44_RS02905 (ETT44_02905) cysK 540725..541666 (-) 942 WP_002991877.1 cysteine synthase A -
  ETT44_RS02910 (ETT44_02910) - 541794..542426 (-) 633 WP_002988970.1 YigZ family protein -
  ETT44_RS02915 (ETT44_02915) comFA/cflA 542481..543806 (+) 1326 WP_002988971.1 DEAD/DEAH box helicase Machinery gene

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23723.38 Da        Isoelectric Point: 5.1641

>NTDB_id=303551 ETT44_RS02890 WP_136021932.1 538252..538893(+) (vraR) [Streptococcus pyogenes strain emm197]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKASKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=303551 ETT44_RS02890 WP_136021932.1 538252..538893(+) (vraR) [Streptococcus pyogenes strain emm197]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGCTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGATATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATTGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

35.841

100

0.38