Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   ETT48_RS06960 Genome accession   NZ_CP035451
Coordinates   1332524..1333165 (-) Length   213 a.a.
NCBI ID   WP_002991888.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm230     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1327524..1338165
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT48_RS06935 (ETT48_06930) comFA/cflA 1327611..1328936 (-) 1326 WP_002993198.1 DEAD/DEAH box helicase Machinery gene
  ETT48_RS06940 (ETT48_06935) - 1328991..1329623 (+) 633 WP_002983676.1 YigZ family protein -
  ETT48_RS06945 (ETT48_06940) cysK 1329751..1330692 (+) 942 WP_002991877.1 cysteine synthase A -
  ETT48_RS06950 (ETT48_06945) - 1330710..1331087 (-) 378 WP_002991882.1 S1 RNA-binding domain-containing protein -
  ETT48_RS06955 (ETT48_06950) - 1331087..1332487 (-) 1401 WP_002991887.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  ETT48_RS06960 (ETT48_06955) vraR 1332524..1333165 (-) 642 WP_002991888.1 response regulator transcription factor Regulator
  ETT48_RS06965 (ETT48_06960) - 1333158..1334162 (-) 1005 WP_002991890.1 sensor histidine kinase -
  ETT48_RS06970 (ETT48_06965) liaF 1334159..1334851 (-) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  ETT48_RS06975 (ETT48_06970) pknB 1334974..1336872 (-) 1899 WP_002994648.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  ETT48_RS06980 (ETT48_06975) - 1336869..1337609 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23767.50 Da        Isoelectric Point: 5.1640

>NTDB_id=303192 ETT48_RS06960 WP_002991888.1 1332524..1333165(-) (vraR) [Streptococcus pyogenes strain emm230]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTCSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=303192 ETT48_RS06960 WP_002991888.1 1332524..1333165(-) (vraR) [Streptococcus pyogenes strain emm230]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAAGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCCTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCTGGTGCTAAAGGTTACATGTTAAAGAC
TTGTAGTGCAGCCGAAATTCTAAATGCTATTCGGAAAGTTTCAAAAGGTGAATTGGCCATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGATATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(148-202)

Response regulator receiver domain (Response_reg)

(6-118)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385

Multiple sequence alignment