Detailed information NTG0302854

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ETT51_RS01375
• Genome accession: NZ_CP035448
• Coordinates: 238039..238779 (+)
• Length: 246 a.a.
• NCBI ID: WP_002992034.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm70
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 233039..243779

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT51_RS01360 (ETT51_01370)	gltX	233569..235014 (+)	1446	WP_002993289.1	glutamate--tRNA ligase	-
ETT51_RS01365 (ETT51_01375)	-	235409..236755 (+)	1347	WP_002991186.1	sensor histidine kinase	-
ETT51_RS01370 (ETT51_01380)	-	236752..238035 (+)	1284	WP_023610148.1	sensor histidine kinase	-
ETT51_RS01375 (ETT51_01385)	comE/blpR	238039..238779 (+)	741	WP_002992034.1	response regulator transcription factor	Regulator
ETT51_RS01380 (ETT51_01390)	rnpA	239319..239678 (+)	360	WP_002992035.1	ribonuclease P protein component	-
ETT51_RS01385 (ETT51_01395)	-	239644..240471 (+)	828	WP_002991181.1	YidC/Oxa1 family membrane protein insertase	-
ETT51_RS01390 (ETT51_01400)	jag	240483..241397 (+)	915	WP_020833245.1	RNA-binding cell elongation regulator Jag/EloR	-
ETT51_RS01395 (ETT51_01405)	rpmH	241712..241846 (+)	135	WP_002885866.1	50S ribosomal protein L34	-
ETT51_RS01400 (ETT51_01410)	-	242120..242824 (+)	705	WP_023610147.1	N-acetylmannosamine-6-phosphate 2-epimerase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28809.41 Da
• Isoelectric Point: 6.8291

>NTDB_id=302854 ETT51_RS01375 WP_002992034.1 238039..238779(+) (comE/blpR) [Streptococcus pyogenes strain emm70]
MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKLFESIQERGDHQLYFLDIEIGEYTRCGLELAAAIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAGGQKQFKGQIEECIRYTYDMMSSRESKDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFENGDSCMVSRLKMKCLFE
RWEALR

Nucleotide

• Length: 741 bp

>NTDB_id=302854 ETT51_RS01375 WP_002992034.1 238039..238779(+) (comE/blpR) [Streptococcus pyogenes strain emm70]
ATGATGAACATTTTTATTCTTGAGGATGATTTTATCCAGCAGACACGCATAGAATCTATCGTAGTAGGCATCTTAAAAGA
GACTAGAATACCATGTAATCAGCTTGAAGTGTTCTCGACTCCTCAAAAATTATTTGAGAGTATCCAAGAAAGAGGAGACC
ATCAGCTGTATTTTTTAGATATTGAAATTGGTGAATATACTCGTTGTGGGCTTGAATTAGCTGCAGCTATTCGACAAAAA
GATCCTAATGCCGTTATTGTGTTTGTCACCACTCATTCAGAATTTGCTCCTATTTCTTTTAAATATAAGGTATCCGCTCT
AGATTTTATTGATAAAGCAGGTGGTCAAAAACAGTTTAAAGGACAAATCGAAGAATGTATCCGATATACTTACGATATGA
TGTCTAGTCGTGAGTCAAAGGACATGTTTTTATTTGAGACTCCACAGACAAGATTAAAATTGCCCTATAAGGATATTTTA
TACTTTGCTACAGCCACAACTCCTCACAAAGTTTGTTTATGGACTCAGACAGAAAGATTAGAGTTTTATGGTAATCTATC
TGAAATTCAAGCAGTAGCACCGAAACTTTTTTTGTGCCATAGATCCTACCTTGTGAATCTAGATAAGGTTGTTCGAATTG
ATAAGAGTAAGCAGCTCCTTTATTTCGAAAATGGTGATTCTTGTATGGTGTCACGATTAAAAATGAAATGTCTGTTTGAA
CGGTGGGAGGCCCTTCGCTAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (152-242)

• Response regulator receiver domain (Response_reg) (4-120)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	46.862	97.154	0.455
comE/comE1	Streptococcus equinus JB1	42.017	96.748	0.407
comE/comE2	Streptococcus equinus JB1	39.431	100	0.394
comE	Streptococcus pneumoniae Rx1	38.525	99.187	0.382
comE	Streptococcus pneumoniae D39	38.525	99.187	0.382
comE	Streptococcus pneumoniae R6	38.525	99.187	0.382
comE	Streptococcus pneumoniae TIGR4	38.525	99.187	0.382
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.903	100	0.382
comE/comE2	Streptococcus gordonii strain NCTC7865	37.903	100	0.382
comE	Streptococcus mitis NCTC 12261	37.759	97.967	0.37
comE	Streptococcus mitis SK321	37.759	97.967	0.37