Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   ETT56_RS02680 Genome accession   NZ_CP035443
Coordinates   518100..518741 (+) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes strain emm58     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 513100..523741
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT56_RS02660 (ETT56_02660) - 513656..514396 (+) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  ETT56_RS02665 (ETT56_02665) pknB 514393..516291 (+) 1899 WP_136115169.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  ETT56_RS02670 (ETT56_02670) liaF 516414..517106 (+) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  ETT56_RS02675 (ETT56_02675) - 517103..518107 (+) 1005 WP_002983669.1 sensor histidine kinase -
  ETT56_RS02680 (ETT56_02680) vraR 518100..518741 (+) 642 WP_002983671.1 response regulator transcription factor Regulator
  ETT56_RS02685 (ETT56_02685) - 518778..520178 (+) 1401 WP_023610569.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  ETT56_RS02690 (ETT56_02690) - 520178..520555 (+) 378 WP_023610575.1 S1 RNA-binding domain-containing protein -
  ETT56_RS02695 (ETT56_02695) cysK 520573..521514 (-) 942 WP_011888673.1 cysteine synthase A -
  ETT56_RS02700 (ETT56_02700) - 521642..522274 (-) 633 WP_032465870.1 YigZ family protein -
  ETT56_RS02705 (ETT56_02705) comFA/cflA 522330..523655 (+) 1326 WP_063633007.1 DEAD/DEAH box helicase Machinery gene

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=302405 ETT56_RS02680 WP_002983671.1 518100..518741(+) (vraR) [Streptococcus pyogenes strain emm58]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=302405 ETT56_RS02680 WP_002983671.1 518100..518741(+) (vraR) [Streptococcus pyogenes strain emm58]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGACATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACATCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385

Multiple sequence alignment