Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   ETT59_RS04935 Genome accession   NZ_CP035440
Coordinates   970076..971872 (-) Length   598 a.a.
NCBI ID   WP_011284753.1    Uniprot ID   Q48TS8
Organism   Streptococcus pyogenes strain emm124     
Function   homologous recombination (predicted from homology)   
Homologous recombination

Genomic Context

Location: 965076..976872
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT59_RS04915 (ETT59_04915) rplJ 965473..965973 (-) 501 WP_002984821.1 50S ribosomal protein L10 -
  ETT59_RS04920 (ETT59_04920) mnmE 966308..967684 (+) 1377 WP_002989919.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
  ETT59_RS04925 (ETT59_04925) pepV 967752..969164 (-) 1413 WP_136276359.1 dipeptidase PepV -
  ETT59_RS04930 (ETT59_04930) - 969289..969891 (-) 603 WP_002989923.1 nitroreductase family protein -
  ETT59_RS04935 (ETT59_04935) uvrC 970076..971872 (-) 1797 WP_011284753.1 excinuclease ABC subunit UvrC Machinery gene
  ETT59_RS04940 (ETT59_04940) - 971974..973371 (-) 1398 WP_014407552.1 NAD-dependent succinate-semialdehyde dehydrogenase -
  ETT59_RS04945 (ETT59_04945) - 973484..974530 (-) 1047 WP_002984833.1 extracellular solute-binding protein -
  ETT59_RS04950 (ETT59_04950) - 974524..975312 (-) 789 WP_002984836.1 response regulator transcription factor -

Sequence

Protein


Download         Length: 598 a.a.        Molecular weight: 68903.72 Da        Isoelectric Point: 9.6587

>NTDB_id=302140 ETT59_RS04935 WP_011284753.1 970076..971872(-) (uvrC) [Streptococcus pyogenes strain emm124]
MNELIKHKLELLPDSPGCYLHKDKEGTIIYVGKAKNLKKRVRSYFRGSHDTKTELLVSEIVDFEYIVTESDTEALLLEIN
LIQKNMPKYNIKLKDDKSYPFLKITNESFPRLVITRYIKKNDGLYFGPYPDSYTANEVKKLLDRIFPFKKCKNPINKVCF
YYHLGQCCAHTICHTDKAYWDRLIDDVKHFLNGKDDKIIEDLRSKMLAASEEMAFERAAEYRDLISGIATMRTKQRVMSK
DLQDRDIFGYYVDKGWMCVQVFFVRQGKLIQRDVNLFPYYNDAEEDFLTYMGQFYQDKQHFIPKEVFIPEAIDEELVAAI
VPTKIIKPKRGEKKQLVALATKNARVSLQQKFDLLEKDIKKTSGAIENLGQLLKIDKPVRIEAFDNSNIQGTSPVAAMVV
FVDGKPSKKDYRKFKIKTVVGPDDYASMREVLFRRYSRVKKEGLQAPNLIIVDGGVGQVNVAKDVIEKQLGLTIPVAGLQ
KNDKHQTHDLLFGNPLEVVPLPRRSEEFFLLHRIQDEVHRFAVTFHRQVRRKNSFSSTLDHISGLGPKRKQLLLRHFKTI
TAIASATSEEIQALGIPKTVVEAIQQQITDNKNDRSSP

Nucleotide


Download         Length: 1797 bp        

>NTDB_id=302140 ETT59_RS04935 WP_011284753.1 970076..971872(-) (uvrC) [Streptococcus pyogenes strain emm124]
ATGAACGAACTGATTAAACATAAACTAGAACTCTTACCAGACAGCCCTGGCTGTTACTTACATAAAGATAAAGAAGGAAC
TATTATCTATGTCGGTAAGGCTAAGAATTTGAAAAAACGCGTCCGGTCCTATTTTCGTGGGAGCCATGATACCAAAACAG
AGTTATTAGTATCTGAGATTGTAGATTTCGAATATATTGTAACAGAGTCAGATACCGAAGCGCTTTTGTTGGAAATTAAC
TTGATTCAAAAAAATATGCCTAAGTACAACATCAAGTTAAAAGATGATAAATCTTATCCCTTTCTAAAAATCACAAATGA
GTCTTTTCCTCGGTTAGTGATTACAAGATATATTAAGAAAAATGATGGATTGTACTTTGGACCCTACCCAGATTCTTACA
CTGCTAATGAAGTTAAAAAGTTATTAGATAGGATTTTTCCGTTTAAAAAGTGTAAAAATCCTATCAATAAGGTCTGTTTT
TATTACCATTTAGGCCAGTGCTGTGCTCATACCATTTGTCATACAGACAAGGCCTATTGGGATCGTTTAATTGATGATGT
TAAGCACTTTTTAAATGGTAAAGATGACAAAATTATTGAAGATCTTCGTTCTAAGATGTTAGCAGCTTCTGAAGAAATGG
CATTTGAACGTGCCGCTGAATATCGAGATTTGATTTCAGGTATTGCCACCATGCGCACCAAGCAGCGGGTGATGAGCAAG
GATTTGCAAGATAGAGATATCTTTGGCTATTATGTTGATAAGGGATGGATGTGTGTCCAAGTTTTCTTTGTGCGTCAAGG
GAAATTAATTCAGCGTGATGTTAACCTTTTTCCCTATTATAACGATGCAGAAGAAGATTTCTTAACTTATATGGGGCAAT
TTTACCAAGATAAACAGCATTTTATCCCTAAAGAAGTCTTTATTCCAGAAGCTATTGATGAAGAACTGGTAGCCGCTATT
GTGCCAACCAAAATCATCAAACCCAAACGCGGTGAAAAAAAACAACTGGTAGCTTTGGCTACTAAGAATGCTCGTGTTAG
TCTGCAACAAAAATTTGATTTATTAGAAAAAGATATCAAAAAAACGAGTGGTGCTATCGAAAATTTAGGTCAGTTACTTA
AGATTGACAAGCCTGTGCGCATTGAAGCCTTTGATAATTCTAACATTCAAGGGACAAGTCCAGTTGCGGCTATGGTTGTT
TTTGTTGATGGCAAACCTAGTAAGAAAGATTATCGTAAATTTAAGATTAAAACAGTGGTGGGACCAGATGATTATGCCAG
TATGAGAGAAGTGCTTTTTCGAAGGTACAGTCGGGTGAAAAAGGAGGGACTGCAAGCTCCTAACTTGATTATTGTTGATG
GAGGCGTTGGACAAGTCAATGTGGCCAAAGATGTGATAGAAAAACAACTTGGACTCACTATTCCTGTTGCGGGACTTCAA
AAAAACGATAAGCACCAGACCCATGATTTGCTTTTTGGAAACCCGCTTGAAGTTGTACCGTTGCCGCGCCGTTCTGAAGA
GTTTTTCTTACTGCATCGGATTCAAGACGAAGTGCATCGCTTTGCAGTTACATTTCATAGACAAGTGCGACGTAAAAATT
CTTTTTCATCAACATTAGATCATATTTCAGGGCTTGGCCCAAAGCGAAAACAGTTATTACTAAGACACTTTAAAACCATA
ACAGCGATTGCATCAGCTACCTCTGAGGAGATTCAAGCTTTAGGTATACCTAAAACAGTAGTTGAAGCAATACAGCAACA
GATAACAGACAATAAAAATGATAGATCGTCTCCTTAA

Domains

Predicted by InterProScan.

UvrB/uvrC motif (UVR)

(196-228)

GIY-YIG catalytic domain (GIY-YIG)

(17-90)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(372-523)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q48TS8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Streptococcus pneumoniae TIGR4

73.684

98.495

0.726
  uvrC Streptococcus pneumoniae R6

73.684

98.495

0.726
  uvrC Streptococcus pneumoniae D39

73.684

98.495

0.726