Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   ETT61_RS09625 Genome accession   NZ_CP035438
Coordinates   1870721..1872703 (-) Length   660 a.a.
NCBI ID   WP_136020112.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm22.8     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1865721..1877703
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT61_RS09600 (ETT61_09590) recA 1865757..1866893 (-) 1137 WP_023612576.1 recombinase RecA Machinery gene
  ETT61_RS09605 (ETT61_09595) cinA 1866982..1868253 (-) 1272 WP_136020115.1 competence/damage-inducible protein A Machinery gene
  ETT61_RS09610 (ETT61_09600) - 1868322..1868882 (-) 561 WP_136020114.1 DNA-3-methyladenine glycosylase I -
  ETT61_RS09615 (ETT61_09605) ruvA 1868892..1869488 (-) 597 WP_002982180.1 Holliday junction branch migration protein RuvA Machinery gene
  ETT61_RS09620 (ETT61_09610) - 1869490..1870710 (-) 1221 WP_136020113.1 MFS transporter -
  ETT61_RS09625 (ETT61_09615) hexB 1870721..1872703 (-) 1983 WP_136020112.1 DNA mismatch repair endonuclease MutL Machinery gene
  ETT61_RS09630 (ETT61_09620) - 1872798..1873943 (-) 1146 WP_032466283.1 site-specific integrase -
  ETT61_RS10465 (ETT61_09625) - 1874208..1874351 (+) 144 WP_011185066.1 putative holin-like toxin -
  ETT61_RS10420 - 1875210..1875719 (-) 510 WP_003049854.1 helix-turn-helix domain-containing protein -
  ETT61_RS09645 (ETT61_09635) - 1875931..1876119 (+) 189 WP_136020111.1 helix-turn-helix domain-containing protein -
  ETT61_RS09650 (ETT61_09640) - 1876135..1876755 (+) 621 WP_136020110.1 Bro-N domain-containing protein -
  ETT61_RS09655 (ETT61_09645) - 1876782..1877024 (+) 243 WP_000648623.1 hypothetical protein -
  ETT61_RS10195 - 1877283..1877453 (+) 171 WP_021775540.1 hypothetical protein -

Sequence

Protein


Download         Length: 660 a.a.        Molecular weight: 74368.05 Da        Isoelectric Point: 5.8725

>NTDB_id=301978 ETT61_RS09625 WP_136020112.1 1870721..1872703(-) (hexB) [Streptococcus pyogenes strain emm22.8]
MTNIIELPEVLANQIAAGEVVERPASVVKELVENAIDAKSSQITVEIEESGLKMIQVTDNGEGMSHEDLPLSLRRHATSK
IKSQSDLFRIRTLGFRGEALPSVASISKITIKTATKEVTHGSLLIATGGEIETLEAISTPTGTKIKVENLFYNTPARLKY
MKSLQAELAHIVDVVNRLSLAHPEVAFTLISDGRQLTQTSGTGDLRQAIAGIYGLNTTKKMLAISNADLDFEVSGYVSLP
ELTRANRNYMTILVNGRYIKNFLLNRAILDGYGSKLMVGRFPIVVIDIQIDPYLADVNVHPTKQEVRISKERELMALIST
AISESLKEQDLIPDALENLAKSSTRHFSKPEQTQLPLQSRGLYYDPQKNDFFVKESAVSEKIPETDFYSGAVDNSVKVEK
AELLPHSEEVIGPSLVKHASRPQNIFTETDHPNLDLKNRQKLSQMLTRLENEEKSVFPELDYFGQMHGTYLFAQGKDGLF
IIDQHAAQERVKYEYYRDKIGEVDSSLQQLLVPYLFEFSGSDFINLQEKMALLNEVGIFLEVYGHNTFILREHPIWMKEE
EIASGVYEMCDMLLLTNEVSIKTYRAELAIMMSCKRSIKANHSLDDYSARNLLLQLAQCQNPYNCPHGRPVLINFSKADM
EKMFRRIQENHTSLRELGKY

Nucleotide


Download         Length: 1983 bp        

>NTDB_id=301978 ETT61_RS09625 WP_136020112.1 1870721..1872703(-) (hexB) [Streptococcus pyogenes strain emm22.8]
ATGACAAACATTATTGAATTACCGGAAGTTCTCGCCAACCAAATTGCAGCTGGTGAAGTTGTAGAAAGGCCAGCGAGTGT
TGTCAAGGAATTGGTTGAGAATGCTATTGATGCTAAAAGTAGCCAGATTACCGTTGAAATTGAAGAGTCTGGCCTTAAGA
TGATACAGGTTACAGACAACGGTGAGGGAATGTCTCATGAAGATTTACCTTTAAGTCTGCGTCGCCACGCTACTAGTAAA
ATTAAGAGTCAGAGTGATTTGTTTAGAATTAGAACACTTGGCTTCCGTGGAGAGGCTTTACCGTCTGTTGCCTCTATCAG
TAAAATCACGATAAAAACAGCAACAAAAGAAGTCACTCACGGTTCTCTTCTTATAGCTACTGGTGGGGAAATTGAGACAC
TTGAAGCGATCTCAACTCCTACTGGAACCAAAATTAAGGTTGAAAACCTTTTTTACAACACGCCTGCTCGTCTCAAATAC
ATGAAAAGTTTACAGGCAGAATTAGCTCACATTGTAGATGTGGTCAACCGGTTGAGTTTGGCACATCCAGAAGTTGCTTT
CACACTGATTAGTGATGGTCGCCAATTAACTCAGACATCAGGAACTGGCGATTTACGCCAAGCAATTGCAGGGATTTATG
GTTTGAATACTACCAAAAAAATGCTGGCTATCTCTAATGCTGATTTGGATTTTGAAGTTTCCGGCTATGTTAGCTTGCCA
GAGTTGACACGCGCCAACCGTAATTACATGACGATTTTGGTTAATGGGCGTTACATCAAGAATTTCTTGCTTAATCGAGC
AATTCTTGATGGTTACGGTTCTAAGCTCATGGTTGGACGTTTCCCAATTGTTGTGATTGATATTCAGATTGATCCCTATT
TGGCCGATGTCAATGTTCATCCCACAAAACAAGAGGTTCGTATTTCAAAAGAGCGTGAGTTGATGGCTTTAATTAGTACG
GCGATTTCTGAAAGTCTTAAGGAACAAGATTTGATTCCAGATGCTCTGGAAAACTTAGCCAAATCAAGCACACGACATTT
CTCTAAACCAGAGCAAACACAACTTCCTTTACAGTCTAGGGGACTTTATTATGATCCTCAAAAGAATGACTTTTTTGTCA
AAGAGTCGGCTGTCTCGGAAAAAATACCTGAAACTGATTTTTATTCCGGCGCTGTTGACAACAGTGTAAAGGTTGAAAAA
GCAGAGCTGTTACCCCACTCAGAAGAAGTTATAGGACCTTCTTTGGTTAAACACGCAAGTCGTCCCCAGAATATCTTTAC
CGAGACTGATCATCCTAATCTTGACTTAAAAAACAGACAAAAGTTATCTCAAATGCTAACCCGTTTGGAAAATGAAGAAA
AATCAGTATTTCCTGAATTGGATTATTTTGGTCAGATGCACGGAACTTATCTCTTTGCTCAGGGAAAAGATGGTTTATTT
ATAATTGACCAACACGCTGCCCAGGAGCGGGTTAAATACGAATATTATCGTGATAAGATAGGTGAGGTTGACAGTAGTTT
ACAGCAATTGTTGGTGCCCTATTTGTTTGAGTTTTCCGGTTCTGATTTCATTAACTTACAGGAGAAAATGGCACTCTTAA
ATGAAGTTGGTATCTTCTTAGAAGTTTATGGGCACAATACTTTCATTTTGAGGGAGCATCCTATCTGGATGAAAGAAGAA
GAGATTGCATCTGGTGTCTATGAAATGTGTGACATGTTACTTCTAACCAATGAGGTATCTATTAAAACTTACCGAGCAGA
GTTAGCTATTATGATGAGTTGTAAACGATCTATCAAGGCAAATCATAGCTTGGATGATTATTCAGCAAGAAATCTGCTAC
TGCAATTGGCCCAATGTCAAAATCCTTATAACTGCCCTCATGGTAGACCCGTGTTGATTAATTTCAGTAAGGCAGATATG
GAAAAAATGTTCCGTCGTATCCAAGAAAATCATACTAGCCTGCGAGAGCTAGGAAAATATTAG

Domains

Predicted by InterProScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-118)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

MutL C terminal dimerisation domain (MutL_C)

(462-604)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

67.018

100

0.674