Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   ETT66_RS02695 Genome accession   NZ_CP035433
Coordinates   517288..517929 (+) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes strain emm65     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 512288..522929
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT66_RS02675 (ETT66_02675) - 512844..513584 (+) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  ETT66_RS02680 (ETT66_02680) pknB 513581..515479 (+) 1899 WP_136286278.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  ETT66_RS02685 (ETT66_02685) liaF 515602..516294 (+) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  ETT66_RS02690 (ETT66_02690) - 516291..517295 (+) 1005 WP_111681220.1 sensor histidine kinase -
  ETT66_RS02695 (ETT66_02695) vraR 517288..517929 (+) 642 WP_002983671.1 response regulator transcription factor Regulator
  ETT66_RS02700 (ETT66_02700) - 517966..519366 (+) 1401 WP_136114036.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  ETT66_RS02705 (ETT66_02705) - 519366..519743 (+) 378 WP_032464495.1 S1 RNA-binding domain-containing protein -
  ETT66_RS02710 (ETT66_02710) cysK 519761..520702 (-) 942 WP_011528853.1 cysteine synthase A -
  ETT66_RS02715 (ETT66_02715) - 520830..521462 (-) 633 WP_002983676.1 YigZ family protein -
  ETT66_RS02720 (ETT66_02720) comFA/cflA 521517..522842 (+) 1326 WP_047235421.1 DEAD/DEAH box helicase Machinery gene

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=301461 ETT66_RS02695 WP_002983671.1 517288..517929(+) (vraR) [Streptococcus pyogenes strain emm65]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=301461 ETT66_RS02695 WP_002983671.1 517288..517929(+) (vraR) [Streptococcus pyogenes strain emm65]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCTGGTGCTAAAGGTTACATGTTAAAGAC
TTCTAGTGCAGCCGAAATTCTAAATGCTATTCGGAAAGTTTCAAAAGGTGAATTGGCCATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGATATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACTCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGATGATAATT
AG

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385