Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   ETT68_RS06590 Genome accession   NZ_CP035431
Coordinates   1297557..1298198 (-) Length   213 a.a.
NCBI ID   WP_032465159.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm105     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1292557..1303198
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT68_RS06565 (ETT68_06560) comFA/cflA 1292643..1293968 (-) 1326 WP_136018894.1 DEAD/DEAH box helicase Machinery gene
  ETT68_RS06570 (ETT68_06565) - 1294024..1294656 (+) 633 WP_009880468.1 YigZ family protein -
  ETT68_RS06575 (ETT68_06570) cysK 1294784..1295725 (+) 942 WP_010922535.1 cysteine synthase A -
  ETT68_RS06580 (ETT68_06575) - 1295743..1296120 (-) 378 WP_109991563.1 S1 RNA-binding domain-containing protein -
  ETT68_RS06585 (ETT68_06580) - 1296120..1297520 (-) 1401 WP_023079249.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  ETT68_RS06590 (ETT68_06585) vraR 1297557..1298198 (-) 642 WP_032465159.1 response regulator transcription factor Regulator
  ETT68_RS06595 (ETT68_06590) - 1298191..1299195 (-) 1005 WP_002991890.1 sensor histidine kinase -
  ETT68_RS06600 (ETT68_06595) liaF 1299192..1299884 (-) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  ETT68_RS06605 (ETT68_06600) pknB 1300007..1301905 (-) 1899 WP_109991562.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  ETT68_RS06610 (ETT68_06605) - 1301902..1302642 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23723.38 Da        Isoelectric Point: 5.0119

>NTDB_id=301302 ETT68_RS06590 WP_032465159.1 1297557..1298198(-) (vraR) [Streptococcus pyogenes strain emm105]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFQHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=301302 ETT68_RS06590 WP_032465159.1 1297557..1298198(-) (vraR) [Streptococcus pyogenes strain emm105]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGATATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCAACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

53.398

96.714

0.516
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385