Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   ETT70_RS06715 Genome accession   NZ_CP035429
Coordinates   1280674..1281315 (-) Length   213 a.a.
NCBI ID   WP_136275908.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emmNA     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1275674..1286315
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT70_RS06690 (ETT70_06680) comFA/cflA 1275761..1277086 (-) 1326 WP_047235421.1 DEAD/DEAH box helicase Machinery gene
  ETT70_RS06695 (ETT70_06685) - 1277141..1277773 (+) 633 WP_002983676.1 YigZ family protein -
  ETT70_RS06700 (ETT70_06690) cysK 1277901..1278842 (+) 942 WP_011528853.1 cysteine synthase A -
  ETT70_RS06705 (ETT70_06695) - 1278860..1279237 (-) 378 WP_032464495.1 S1 RNA-binding domain-containing protein -
  ETT70_RS06710 (ETT70_06700) - 1279237..1280637 (-) 1401 WP_136115800.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  ETT70_RS06715 (ETT70_06705) vraR 1280674..1281315 (-) 642 WP_136275908.1 response regulator transcription factor Regulator
  ETT70_RS06720 (ETT70_06710) - 1281308..1282312 (-) 1005 WP_002991890.1 sensor histidine kinase -
  ETT70_RS06725 (ETT70_06715) liaF 1282309..1283001 (-) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  ETT70_RS06730 (ETT70_06720) pknB 1283124..1285022 (-) 1899 WP_111681221.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  ETT70_RS06735 (ETT70_06725) - 1285019..1285759 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23781.46 Da        Isoelectric Point: 5.1641

>NTDB_id=301111 ETT70_RS06715 WP_136275908.1 1280674..1281315(-) (vraR) [Streptococcus pyogenes strain emmNA]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVSEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=301111 ETT70_RS06715 WP_136275908.1 1280674..1281315(-) (vraR) [Streptococcus pyogenes strain emmNA]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTAGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGATATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATTGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.427

96.714

0.507
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385