Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   SPT_RS01070 Genome accession   NC_012469
Coordinates   186941..188890 (+) Length   649 a.a.
NCBI ID   WP_000018164.1    Uniprot ID   C1CP43
Organism   Streptococcus pneumoniae Taiwan19F-14     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 181941..193890
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPT_RS01050 (SPT_0206) - 182423..183769 (-) 1347 WP_012677168.1 IS1380-like element ISSpn5 family transposase -
  SPT_RS01055 (SPT_0207) - 184118..185380 (-) 1263 WP_000075789.1 NRAMP family divalent metal transporter -
  SPT_RS01060 (SPT_0208) - 185690..186148 (-) 459 WP_000745055.1 DUF3021 domain-containing protein -
  SPT_RS01065 (SPT_0209) brsR 186145..186585 (-) 441 WP_000861967.1 LytTR family DNA-binding domain-containing protein Regulator
  SPT_RS13220 (SPT_0210) - 186673..186798 (-) 126 WP_001822433.1 hypothetical protein -
  SPT_RS01070 (SPT_0211) hexB 186941..188890 (+) 1950 WP_000018164.1 DNA mismatch repair endonuclease MutL Machinery gene
  SPT_RS01075 (SPT_0212) ribE 189215..189682 (-) 468 WP_001099502.1 6,7-dimethyl-8-ribityllumazine synthase -
  SPT_RS01080 (SPT_0213) - 189683..190888 (-) 1206 WP_001814751.1 bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II -
  SPT_RS01085 (SPT_0214) ribE 190908..191543 (-) 636 WP_000493846.1 riboflavin synthase -
  SPT_RS01090 (SPT_0215) ribD 191528..192628 (-) 1101 WP_001284108.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
  SPT_RS01095 (SPT_0216) ruvA 193033..193626 (+) 594 WP_000271492.1 Holliday junction branch migration protein RuvA Machinery gene

Sequence

Protein


Download         Length: 649 a.a.        Molecular weight: 73420.86 Da        Isoelectric Point: 5.2987

>NTDB_id=30098 SPT_RS01070 WP_000018164.1 186941..188890(+) (hexB) [Streptococcus pneumoniae Taiwan19F-14]
MSHIIELPEMLANQIAAGEVIERPASVVKELVENAIDAGSSQIIIEIEEAGLKKVQITDNGHGIAHDEVELALRRHATSK
IKNQADLFRIRTLGFRGEALPSIASVSVLTLLTAVDGASHGTKLVARGGEVEEVIPATSPVGTKVCVEDLFFNTPARLKY
MKSQQAELSHIIDIVNRLGLAHPEISFSLISDGKEMTRTAGTGQLRQAIAGIYGLVSAKKMIEIENSDLDFEISGFVSLP
ELTRANRNYISLFINGRYIKNFLLNRAILDGFGSKLMVGRFPLAVIHIHIDPYLADVNVHPTKQEVRISKEKELMTLVSE
AIANSLKEQTLIPDALENLAKSTVRNREKVDQTILPLKENTLYYEKTEPSRPSQTEVADYQVELTDEGQDLTLFAKETLD
RLTKPAKLHFAERKPANYDQLDHPELDLASIDKAYDKLEREEASSFPELEFFGQMHGTYLFAQGRDGLYIIDQHAAQERV
KYEEYRESIGNVDQSQQQLLVPYIFEFPADDALRLKERMPLLEEVGVFLAEYGENQFILREHPIWMAEEEIESGIYEMCD
MLLLTKEVSIKKYRAELAIMMSCKRSIKANHRIDDHSARQLLYQLSQCDNPYNCPHGRPVLVHFTKSDMEKMFRRIQENH
TSLRELGKY

Nucleotide


Download         Length: 1950 bp        

>NTDB_id=30098 SPT_RS01070 WP_000018164.1 186941..188890(+) (hexB) [Streptococcus pneumoniae Taiwan19F-14]
ATGTCTCATATTATTGAATTGCCAGAGATGCTGGCAAACCAAATCGCGGCTGGAGAGGTCATTGAACGTCCTGCCAGTGT
GGTCAAAGAGTTGGTAGAAAATGCCATTGACGCGGGCTCTAGTCAGATTATCATTGAGATTGAGGAAGCTGGTCTCAAGA
AGGTTCAAATCACGGATAACGGTCATGGAATTGCCCACGATGAGGTGGAGTTGGCCCTGCGTCGCCATGCGACCAGTAAG
ATAAAAAATCAAGCAGATCTCTTTCGGATTCGGACGCTTGGTTTTCGTGGTGAAGCCTTGCCTTCTATTGCGTCTGTTAG
TGTCTTGACTCTGTTAACGGCGGTGGATGGTGCTAGTCATGGAACCAAGTTAGTCGCGCGCGGGGGTGAAGTTGAGGAAG
TCATCCCAGCGACTAGTCCTGTGGGAACCAAGGTTTGTGTGGAGGATCTCTTTTTCAACACGCCTGCCCGTCTCAAGTAT
ATGAAGAGCCAGCAAGCGGAGTTGTCTCATATCATTGATATTGTCAACCGTCTGGGCTTGGCCCATCCTGAGATTTCTTT
TAGCTTGATTAGTGATGGCAAGGAAATGACGCGGACAGCAGGGACTGGTCAATTGCGCCAAGCAATCGCAGGGATTTACG
GTTTGGTCAGTGCCAAGAAGATGATTGAAATTGAGAACTCTGACCTAGATTTCGAAATTTCAGGTTTTGTGTCCTTGCCT
GAGTTGACTCGGGCTAACCGCAATTATATCAGCCTCTTCATCAATGGTCGTTATATCAAGAACTTCCTGCTCAATCGTGC
TATTTTGGATGGTTTCGGAAGCAAGCTTATGGTTGGACGTTTTCCACTGGCTGTCATTCACATCCATATCGACCCTTATC
TAGCGGATGTCAATGTGCATCCAACTAAGCAAGAGGTGCGGATTTCCAAGGAAAAAGAACTGATGACCCTGGTTTCAGAA
GCTATTGCAAATAGTCTCAAGGAACAAACCTTGATTCCAGATGCCTTGGAAAATCTTGCCAAATCGACCGTGCGCAATCG
TGAGAAGGTGGATCAAACTATTCTCCCACTCAAAGAAAATACGCTCTACTATGAGAAAACTGAGCCGTCAAGACCTAGTC
AAACTGAAGTAGCTGATTATCAGGTAGAATTGACTGATGAAGGGCAGGATTTGACCCTGTTTGCCAAGGAAACCTTGGAC
CGATTGACCAAGCCAGCAAAACTGCATTTTGCAGAGAGAAAGCCTGCTAACTACGACCAGCTAGACCATCCAGAGTTAGA
TCTTGCTAGCATCGATAAGGCTTATGACAAACTGGAGCGAGAAGAAGCATCCAGCTTCCCAGAGTTGGAGTTTTTCGGAC
AAATGCACGGGACTTATCTCTTTGCCCAAGGGCGAGATGGACTTTACATCATAGATCAGCACGCTGCTCAGGAACGGGTC
AAGTACGAGGAGTACCGTGAAAGCATTGGCAATGTTGACCAGAGCCAGCAGCAACTCCTAGTGCCCTATATCTTTGAATT
TCCTGCGGATGATGCCCTGCGTCTCAAGGAAAGAATGCCTCTCTTAGAGGAAGTGGGCGTCTTTCTAGCAGAGTACGGAG
AAAATCAATTTATTCTACGTGAACATCCTATTTGGATGGCAGAAGAAGAGATTGAATCAGGCATCTATGAGATGTGCGAC
ATGCTCCTTTTGACCAAGGAAGTTTCTATCAAGAAATACCGAGCAGAGCTGGCTATCATGATGTCTTGCAAGCGATCTAT
CAAGGCCAATCATCGTATTGATGATCATTCAGCTAGACAACTCCTCTATCAGCTTTCTCAATGTGACAATCCCTATAACT
GTCCTCACGGACGTCCTGTTTTGGTGCATTTTACCAAGTCGGATATGGAAAAGATGTTCCGACGTATTCAGGAAAATCAC
ACCAGTCTCCGTGAGTTGGGGAAATATTAA

Domains

Predicted by InterProScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-107)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

MutL C terminal dimerisation domain (MutL_C)

(450-592)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB C1CP43

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

99.846

100

0.998

Multiple sequence alignment