Detailed information NTG0030037

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: SPH_RS10320
• Genome accession: NC_010380
• Coordinates: 1947498..1948535 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae Hungary19A-6
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1942498..1953535

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPH_RS10295 (SPH_2105)	-	1943237..1944568 (-)	1332	WP_000390042.1	hemolysin family protein	-
SPH_RS10300 (SPH_2106)	endA	1944859..1945683 (-)	825	WP_001036790.1	DNA-entry nuclease EndA	Machinery gene
SPH_RS10305 (SPH_2107)	-	1945722..1945910 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
SPH_RS10310 (SPH_2108)	murA	1945903..1947186 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
SPH_RS10315 (SPH_2109)	-	1947210..1947440 (-)	231	WP_000250391.1	DUF1146 family protein	-
SPH_RS10320 (SPH_2110)	sepM	1947498..1948535 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
SPH_RS10325 (SPH_2111)	coaD	1948519..1949007 (-)	489	WP_001280746.1	pantetheine-phosphate adenylyltransferase	-
SPH_RS10330 (SPH_2112)	rsmD	1948997..1949536 (-)	540	WP_000691938.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
SPH_RS10335 (SPH_2113)	asnA	1949601..1950593 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
SPH_RS10340 (SPH_2114)	-	1950706..1951389 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
SPH_RS10345 (SPH_2115)	-	1951445..1952185 (-)	741	WP_000152674.1	RNA methyltransferase	-
SPH_RS10350 (SPH_2116)	-	1952219..1952497 (+)	279	WP_001174613.1	acylphosphatase	-
SPH_RS10355 (SPH_2117)	yidC	1952575..1953501 (+)	927	WP_000835944.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=30037 SPH_RS10320 WP_000727277.1 1947498..1948535(-) (sepM) [Streptococcus pneumoniae Hungary19A-6]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=30037 SPH_RS10320 WP_000727277.1 1947498..1948535(-) (sepM) [Streptococcus pneumoniae Hungary19A-6]
ATGAAAAAAAAGATTAGATGGCCCTTGTATGTCATTGCGGCCTTGATTGTGACCTTCTTGGCATTTGTGGTGCCTTTGCC
CTACTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCTACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGACTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGAAAAAATGGGATTGGAATCGGCTTGATTGATCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGACCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591