Detailed information NTG0030035

Bioinformatically predicted

Overview

• Name: braR
• Type: Regulator
• Locus tag: SP70585_RS08295
• Genome accession: NC_012468
• Coordinates: 1545229..1545906 (-)
• Length: 225 a.a.
• NCBI ID: WP_000548959.1
• Uniprot ID: Q9S1K2
• Organism: Streptococcus pneumoniae 70585
• Function: promote expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1540229..1550906

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SP70585_RS08265 (SP70585_1668)	-	1540390..1541019 (-)	630	WP_000762090.1	NAD(P)-dependent oxidoreductase	-
SP70585_RS14315	-	1541258..1541632 (+)	375	Protein_1580	hypothetical protein	-
SP70585_RS08275 (SP70585_1670)	-	1541889..1542029 (+)	141	WP_000422775.1	MazG-like protein	-
SP70585_RS08280 (SP70585_1671)	-	1542036..1542212 (+)	177	WP_000166031.1	MazG-like protein	-
SP70585_RS08285 (SP70585_1672)	thrS	1542270..1544213 (+)	1944	WP_000608349.1	threonine--tRNA ligase	-
SP70585_RS08290 (SP70585_1673)	-	1544262..1545236 (-)	975	WP_000887953.1	HAMP domain-containing histidine kinase	-
SP70585_RS08295 (SP70585_1674)	braR	1545229..1545906 (-)	678	WP_000548959.1	response regulator transcription factor	Regulator
SP70585_RS08300 (SP70585_1675)	-	1546062..1547135 (+)	1074	WP_001273829.1	DUF2974 domain-containing protein	-
SP70585_RS08305 (SP70585_1676)	-	1547226..1547528 (-)	303	WP_000281614.1	hypothetical protein	-
SP70585_RS08310 (SP70585_1677)	-	1547597..1548034 (-)	438	WP_001166786.1	Rrf2 family transcriptional regulator	-
SP70585_RS08315 (SP70585_1678)	-	1548110..1548952 (-)	843	WP_000160934.1	metallophosphoesterase	-
SP70585_RS08320 (SP70585_1679)	-	1549064..1549714 (+)	651	WP_000188502.1	metal-dependent transcriptional regulator	-
SP70585_RS14320 (SP70585_1680)	-	1549695..1549886 (+)	192	WP_001820758.1	hypothetical protein	-
SP70585_RS08330 (SP70585_1681)	-	1549912..1550559 (+)	648	WP_000260187.1	nicotinamide mononucleotide transporter	-

Sequence

Protein

• Length: 225 a.a.
• Molecular weight: 25964.16 Da
• Isoelectric Point: 5.1362

>NTDB_id=30035 SP70585_RS08295 WP_000548959.1 1545229..1545906(-) (braR) [Streptococcus pneumoniae 70585]
MHKILLIEDDQVIRQQIGKMLSEWGFEVVLVEDFMEVLSLFVQSEPHLVLMDIGLPLFNGYHWCQEIRKISKVPIMFLSS
RDQAMDIVMAINMGADDFVTKPFDQQVLLAKVQGLLRRSYEFGRDESLLEYAGVILNTKSMDLHYQGQVLNLTKNEFQIL
RVLFEHAGNIVARDDLMRELWNSDFFIDDNTLSVNVARLRKKLEEQGLVGFIETKKGIGYGLKHA

Nucleotide

• Length: 678 bp

>NTDB_id=30035 SP70585_RS08295 WP_000548959.1 1545229..1545906(-) (braR) [Streptococcus pneumoniae 70585]
ATGCACAAGATTTTATTAATAGAAGATGATCAGGTCATTCGTCAACAGATTGGGAAAATGCTCTCTGAATGGGGATTTGA
AGTGGTCCTGGTAGAAGACTTTATGGAAGTTTTGAGTCTATTTGTTCAGTCGGAACCTCATCTGGTCCTCATGGATATTG
GTTTGCCCTTGTTTAATGGTTATCACTGGTGTCAGGAAATCCGCAAGATTTCCAAGGTACCTATCATGTTTCTTTCTTCG
AGAGACCAGGCTATGGATATTGTCATGGCAATCAATATGGGGGCGGATGACTTTGTGACCAAGCCTTTTGACCAGCAGGT
TCTTTTAGCTAAGGTTCAGGGCTTGTTGCGTCGTTCCTATGAGTTTGGGCGTGATGAGAGTTTGCTGGAATATGCTGGTG
TTATCCTCAATACCAAATCCATGGATTTACATTATCAAGGGCAAGTCTTGAATTTGACCAAGAATGAATTCCAGATTTTA
CGCGTGTTATTTGAGCATGCAGGCAACATCGTAGCACGTGACGACCTGATGCGGGAACTTTGGAACAGTGACTTTTTCAT
TGATGATAATACCCTCTCTGTCAATGTGGCTCGTTTGCGTAAAAAGTTGGAGGAGCAGGGATTGGTAGGATTTATCGAGA
CCAAGAAAGGAATAGGGTACGGATTGAAGCATGCTTGA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (147-221)

3D structure

• AlphaFold DB: Q9S1K2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
braR	Staphylococcus aureus N315	48.624	96.889	0.471
vicR	Streptococcus mutans UA159	35.319	100	0.369