Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   SPP_RS02115 Genome accession   NC_012467
Coordinates   381188..381820 (+) Length   210 a.a.
NCBI ID   WP_000698434.1    Uniprot ID   Q9S1J7
Organism   Streptococcus pneumoniae P1031     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 376188..386820
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPP_RS02090 (SPP_0420) mvaD 376466..377419 (+) 954 WP_000373458.1 diphosphomevalonate decarboxylase -
  SPP_RS02095 (SPP_0421) - 377406..378413 (+) 1008 WP_000562430.1 phosphomevalonate kinase -
  SPP_RS02100 (SPP_0422) fni 378397..379407 (+) 1011 WP_000210617.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  SPP_RS02105 (SPP_0423) liaF 379484..380182 (+) 699 WP_001224637.1 cell wall-active antibiotics response protein LiaF -
  SPP_RS02110 (SPP_0424) - 380179..381174 (+) 996 WP_000743661.1 sensor histidine kinase -
  SPP_RS02115 (SPP_0425) vraR 381188..381820 (+) 633 WP_000698434.1 response regulator transcription factor Regulator
  SPP_RS13685 - 381896..382590 (+) 695 Protein_407 DNA alkylation repair protein -
  SPP_RS02135 (SPP_0429) - 382740..382979 (+) 240 WP_000754501.1 hypothetical protein -
  SPP_RS02140 (SPP_0430) cbpG 383060..383650 (+) 591 Protein_409 choline-binding protein CbpG -
  SPP_RS02145 (SPP_0431) - 383952..384344 (+) 393 WP_000378125.1 tyrosine-type recombinase/integrase -
  SPP_RS02150 (SPP_0432) tig 384505..385788 (+) 1284 WP_000116465.1 trigger factor -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23553.03 Da        Isoelectric Point: 4.5791

>NTDB_id=29867 SPP_RS02115 WP_000698434.1 381188..381820(+) (vraR) [Streptococcus pneumoniae P1031]
MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIV
TSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQEEF

Nucleotide


Download         Length: 633 bp        

>NTDB_id=29867 SPP_RS02115 WP_000698434.1 381188..381820(+) (vraR) [Streptococcus pneumoniae P1031]
ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGATTGGGCTTGAAAAGCTACTTTGACCTCCAAGACGATGTAGA
AGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGACTTGGCCTTGGAACTGCGTCCAGATGTCATTGTCATGGATA
TTGTCATGCCTGAGATGAATGGGATTGACGCGACCTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTATATGCTCAAGACTTCTAGTGC
AGATGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGCGAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAAT
ACCACCGCAATCATATGGAACTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
GAAAATCAGCGCATCGCAGATGACCTCTTTATCTCTCTCAAGACGGTCAAGACCCACGTGTCCAATATTCTTGCCAAACT
TGAAGTCAGCGATCGTACCCAGGCGGCTGTCTATGCCTTTCAGCACCATTTGGTGGGGCAAGAGGAGTTTTAG

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(145-199)

Response regulator receiver domain (Response_reg)

(3-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1J7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.153

99.524

0.519
  degU Bacillus subtilis subsp. subtilis str. 168

38.393

100

0.41