Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   SPP_RS01150 Genome accession   NC_012467
Coordinates   194661..196610 (+) Length   649 a.a.
NCBI ID   WP_000018164.1    Uniprot ID   C1CP43
Organism   Streptococcus pneumoniae P1031     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 189661..201610
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPP_RS01125 (SPP_0226) - 190614..191147 (+) 534 WP_000729037.1 hypothetical protein -
  SPP_RS01130 (SPP_0227) nrdI 191225..191695 (+) 471 WP_000849618.1 class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI -
  SPP_RS01135 (SPP_0228) - 191988..193250 (-) 1263 WP_000075789.1 NRAMP family divalent metal transporter -
  SPP_RS01140 (SPP_0229) - 193560..194018 (-) 459 WP_000745054.1 DUF3021 domain-containing protein -
  SPP_RS01145 (SPP_0230) brsR 194015..194455 (-) 441 WP_000861968.1 LytTR family DNA-binding domain-containing protein Regulator
  SPP_RS01150 (SPP_0231) hexB 194661..196610 (+) 1950 WP_000018164.1 DNA mismatch repair endonuclease MutL Machinery gene
  SPP_RS01155 (SPP_0232) ribE 196935..197402 (-) 468 WP_001099502.1 6,7-dimethyl-8-ribityllumazine synthase -
  SPP_RS01160 (SPP_0233) - 197403..198608 (-) 1206 WP_000456639.1 bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II -
  SPP_RS01165 (SPP_0234) ribE 198628..199263 (-) 636 WP_000493842.1 riboflavin synthase -
  SPP_RS01170 (SPP_0235) ribD 199248..200348 (-) 1101 WP_001284090.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
  SPP_RS01175 (SPP_0236) ruvA 200753..201346 (+) 594 WP_000271493.1 Holliday junction branch migration protein RuvA Machinery gene

Sequence

Protein


Download         Length: 649 a.a.        Molecular weight: 73420.86 Da        Isoelectric Point: 5.2987

>NTDB_id=29858 SPP_RS01150 WP_000018164.1 194661..196610(+) (hexB) [Streptococcus pneumoniae P1031]
MSHIIELPEMLANQIAAGEVIERPASVVKELVENAIDAGSSQIIIEIEEAGLKKVQITDNGHGIAHDEVELALRRHATSK
IKNQADLFRIRTLGFRGEALPSIASVSVLTLLTAVDGASHGTKLVARGGEVEEVIPATSPVGTKVCVEDLFFNTPARLKY
MKSQQAELSHIIDIVNRLGLAHPEISFSLISDGKEMTRTAGTGQLRQAIAGIYGLVSAKKMIEIENSDLDFEISGFVSLP
ELTRANRNYISLFINGRYIKNFLLNRAILDGFGSKLMVGRFPLAVIHIHIDPYLADVNVHPTKQEVRISKEKELMTLVSE
AIANSLKEQTLIPDALENLAKSTVRNREKVDQTILPLKENTLYYEKTEPSRPSQTEVADYQVELTDEGQDLTLFAKETLD
RLTKPAKLHFAERKPANYDQLDHPELDLASIDKAYDKLEREEASSFPELEFFGQMHGTYLFAQGRDGLYIIDQHAAQERV
KYEEYRESIGNVDQSQQQLLVPYIFEFPADDALRLKERMPLLEEVGVFLAEYGENQFILREHPIWMAEEEIESGIYEMCD
MLLLTKEVSIKKYRAELAIMMSCKRSIKANHRIDDHSARQLLYQLSQCDNPYNCPHGRPVLVHFTKSDMEKMFRRIQENH
TSLRELGKY

Nucleotide


Download         Length: 1950 bp        

>NTDB_id=29858 SPP_RS01150 WP_000018164.1 194661..196610(+) (hexB) [Streptococcus pneumoniae P1031]
ATGTCTCATATTATTGAATTGCCAGAGATGCTGGCAAACCAAATCGCAGCTGGGGAGGTCATTGAACGTCCTGCCAGTGT
GGTTAAAGAGTTGGTAGAAAATGCCATTGACGCGGGCTCTAGTCAGATTATCATTGAGATTGAGGAAGCTGGTCTCAAGA
AGGTTCAAATCACGGATAACGGTCATGGAATTGCCCACGATGAGGTGGAGTTGGCCCTGCGTCGCCATGCGACCAGTAAG
ATAAAAAATCAAGCAGATCTCTTTCGGATTCGGACGCTTGGTTTTCGTGGTGAAGCCTTGCCTTCTATTGCGTCTGTTAG
TGTCTTGACTCTGTTAACGGCGGTGGATGGTGCTAGTCATGGAACCAAGTTAGTCGCGCGTGGGGGTGAAGTTGAGGAAG
TCATCCCAGCGACTAGTCCTGTGGGAACCAAGGTTTGTGTGGAGGATCTCTTTTTCAACACGCCTGCCCGTCTCAAGTAT
ATGAAGAGCCAGCAAGCGGAGTTGTCTCATATCATTGATATTGTCAACCGTCTGGGCTTGGCCCATCCTGAGATTTCTTT
TAGCTTGATTAGTGATGGCAAGGAAATGACGCGGACAGCAGGGACTGGTCAATTGCGCCAAGCAATCGCAGGGATTTACG
GTTTGGTCAGTGCCAAGAAGATGATTGAAATTGAGAACTCTGACCTAGATTTCGAAATTTCAGGTTTTGTGTCCTTGCCT
GAGTTGACTCGGGCTAACCGCAATTATATCAGCCTCTTCATCAATGGTCGTTATATCAAGAACTTCCTGCTCAATCGTGC
TATTTTGGATGGTTTCGGAAGCAAGCTTATGGTTGGACGTTTTCCACTGGCTGTCATTCACATCCATATCGACCCTTATC
TAGCGGATGTCAATGTGCATCCAACTAAGCAAGAGGTGCGGATTTCCAAGGAAAAAGAACTGATGACCCTGGTTTCAGAA
GCTATTGCAAATAGTCTCAAGGAACAAACCTTGATTCCAGATGCCTTGGAAAATCTTGCCAAATCGACCGTGCGCAATCG
TGAGAAGGTGGATCAAACTATTCTCCCACTCAAAGAAAATACGCTCTACTATGAGAAAACTGAGCCGTCAAGACCTAGTC
AAACTGAAGTAGCTGATTATCAGGTAGAATTGACTGATGAAGGGCAGGATTTGACCCTGTTTGCCAAGGAAACCTTGGAC
CGATTGACCAAGCCAGCAAAACTGCATTTTGCAGAGAGAAAGCCTGCTAACTACGACCAGCTAGACCATCCAGAGTTAGA
TCTTGCTAGCATCGATAAGGCTTATGACAAACTGGAGCGAGAAGAAGCATCCAGCTTCCCAGAGTTGGAGTTTTTCGGAC
AAATGCACGGGACTTATCTCTTTGCCCAAGGGCGAGATGGACTTTACATCATAGATCAGCACGCTGCTCAGGAACGGGTC
AAGTACGAGGAGTACCGTGAAAGCATTGGCAATGTTGACCAGAGCCAGCAGCAACTCCTAGTGCCCTATATCTTTGAATT
TCCTGCGGATGATGCCCTGCGTCTCAAGGAAAGAATGCCTCTCTTAGAGGAAGTGGGCGTCTTTCTAGCAGAGTACGGAG
AAAATCAATTTATTCTACGTGAACATCCTATTTGGATGGCAGAAGAAGAGATTGAATCAGGCATCTATGAGATGTGCGAC
ATGCTCCTTTTGACCAAGGAAGTTTCTATCAAGAAATACCGAGCAGAGTTGGCTATCATGATGTCTTGCAAGCGATCTAT
CAAGGCCAATCATCGTATTGATGATCATTCAGCTAGACAACTCCTCTATCAGCTTTCTCAATGTGACAATCCCTATAACT
GTCCTCACGGACGTCCTGTTTTGGTGCATTTTACCAAGTCGGATATGGAAAAGATGTTCCGACGTATTCAGGAAAATCAT
ACCAGTCTCCGTGAGTTGGGGAAATATTAA

Domains

Predicted by InterProScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-107)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

MutL C terminal dimerisation domain (MutL_C)

(450-592)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB C1CP43

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

99.846

100

0.998

Multiple sequence alignment