Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   EQH18_RS01845 Genome accession   NZ_CP035262
Coordinates   367669..368301 (+) Length   210 a.a.
NCBI ID   WP_000698434.1    Uniprot ID   Q9S1J7
Organism   Streptococcus pneumoniae strain TVO_1901923     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 362669..373301
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH18_RS01820 (EQH18_01935) mvaD 362947..363900 (+) 954 WP_000373458.1 diphosphomevalonate decarboxylase -
  EQH18_RS01825 (EQH18_01940) - 363887..364894 (+) 1008 WP_000562431.1 phosphomevalonate kinase -
  EQH18_RS01830 (EQH18_01945) fni 364878..365888 (+) 1011 WP_000210617.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  EQH18_RS01835 (EQH18_01950) liaF 365965..366663 (+) 699 WP_001224637.1 cell wall-active antibiotics response protein LiaF -
  EQH18_RS01840 (EQH18_01955) - 366660..367655 (+) 996 WP_000743661.1 sensor histidine kinase -
  EQH18_RS01845 (EQH18_01960) vraR 367669..368301 (+) 633 WP_000698434.1 response regulator transcription factor Regulator
  EQH18_RS01850 - 368376..369070 (+) 695 Protein_370 DNA alkylation repair protein -
  EQH18_RS01855 (EQH18_01980) - 369220..369459 (+) 240 WP_000754501.1 hypothetical protein -
  EQH18_RS01860 (EQH18_01985) cbpG 369540..370130 (+) 591 Protein_372 choline-binding protein CbpG -
  EQH18_RS01865 (EQH18_01990) - 370486..370824 (+) 339 WP_001812733.1 tyrosine-type recombinase/integrase -
  EQH18_RS01870 (EQH18_01995) - 370904..371485 (-) 582 WP_061645657.1 IS30 family transposase -
  EQH18_RS01875 (EQH18_02000) tig 371859..373142 (+) 1284 WP_000116465.1 trigger factor -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23553.03 Da        Isoelectric Point: 4.5791

>NTDB_id=297645 EQH18_RS01845 WP_000698434.1 367669..368301(+) (vraR) [Streptococcus pneumoniae strain TVO_1901923]
MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIV
TSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQEEF

Nucleotide


Download         Length: 633 bp        

>NTDB_id=297645 EQH18_RS01845 WP_000698434.1 367669..368301(+) (vraR) [Streptococcus pneumoniae strain TVO_1901923]
ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGTTTGGGCTTGAAAAGCTACTTTGACCTCCAAGACGATGTAGA
AGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGACTTGGCCTTGGAACTGCGTCCAGATGTTATTGTCATGGATA
TTGTCATGCCTGAGATGAATGGGATTGACGCGACCTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTATATGCTCAAGACTTCTAGTGC
AGATGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGCGAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAAT
ACCACCGCAATCATATGGAACTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
GAAAATCAGCGCATCGCAGATGACCTCTTTATCTCTCTCAAGACGGTCAAGACCCACGTGTCCAACATTCTTGCCAAACT
TGAAGTCAGCGATCGTACTCAGGCGGCTGTCTATGCCTTTCAGCACCATTTGGTGGGGCAAGAGGAGTTTTAG

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(145-199)

Response regulator receiver domain (Response_reg)

(3-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1J7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.153

99.524

0.519
  degU Bacillus subtilis subsp. subtilis str. 168

38.393

100

0.41