Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   EQH34_RS01875 Genome accession   NZ_CP035246
Coordinates   376376..377008 (+) Length   210 a.a.
NCBI ID   WP_000698434.1    Uniprot ID   Q9S1J7
Organism   Streptococcus pneumoniae strain TVO_1901941     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 371376..382008
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH34_RS01850 (EQH34_01980) mvaD 371653..372606 (+) 954 WP_000373461.1 diphosphomevalonate decarboxylase -
  EQH34_RS01855 (EQH34_01985) - 372593..373600 (+) 1008 WP_000562422.1 phosphomevalonate kinase -
  EQH34_RS01860 (EQH34_01990) fni 373584..374594 (+) 1011 WP_000210619.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  EQH34_RS01865 (EQH34_01995) liaF 374672..375370 (+) 699 WP_001224637.1 cell wall-active antibiotics response protein LiaF -
  EQH34_RS01870 (EQH34_02000) - 375367..376362 (+) 996 WP_000743683.1 sensor histidine kinase -
  EQH34_RS01875 (EQH34_02005) vraR 376376..377008 (+) 633 WP_000698434.1 response regulator transcription factor Regulator
  EQH34_RS01880 - 377084..377778 (+) 695 Protein_370 DNA alkylation repair protein -
  EQH34_RS01885 (EQH34_02025) - 377928..378167 (+) 240 WP_000754502.1 hypothetical protein -
  EQH34_RS01890 (EQH34_02030) cbpG 378248..378842 (+) 595 Protein_372 choline-binding protein CbpG -
  EQH34_RS01895 (EQH34_02035) - 379198..379536 (+) 339 WP_001812733.1 tyrosine-type recombinase/integrase -
  EQH34_RS01900 (EQH34_02040) tig 379697..380980 (+) 1284 WP_000116466.1 trigger factor -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23553.03 Da        Isoelectric Point: 4.5791

>NTDB_id=296080 EQH34_RS01875 WP_000698434.1 376376..377008(+) (vraR) [Streptococcus pneumoniae strain TVO_1901941]
MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIV
TSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQEEF

Nucleotide


Download         Length: 633 bp        

>NTDB_id=296080 EQH34_RS01875 WP_000698434.1 376376..377008(+) (vraR) [Streptococcus pneumoniae strain TVO_1901941]
ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGTTTGGGTTTGAAAAGCTACTTTGACCTCCAAGACGATGTAGA
AGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGACTTGGCCTTGGAACTGCGTCCAGATGTCATTGTCATGGATA
TTGTCATGCCTGAGATGAATGGGATTGACGCGACTTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTATATGCTCAAGACTTCTAGTGC
AGATGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGCGAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAAT
ACCACCGCAATCATATGGAACTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
GAAAATCAGCGCATCGCAGATGACCTCTTTATCTCTCTCAAGACGGTCAAGACCCACGTGTCCAATATTCTTGCCAAACT
TGAAGTCAGCGATCGTACCCAGGCGGCTGTCTATGCCTTTCAGCACCATTTGGTGGGGCAAGAGGAGTTTTAG

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(145-199)

Response regulator receiver domain (Response_reg)

(3-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1J7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.153

99.524

0.519
  degU Bacillus subtilis subsp. subtilis str. 168

38.393

100

0.41