Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | C7M54_RS00525 | Genome accession | NZ_CP029685 |
| Coordinates | 96757..98103 (-) | Length | 448 a.a. |
| NCBI ID | WP_000816499.1 | Uniprot ID | Q9R3W9 |
| Organism | Staphylococcus aureus strain CMRSA-3 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 40889..104598 | 96757..98103 | within | 0 |
| SCCmec | 40889..98103 | 96757..98103 | within | 0 |
Gene organization within MGE regions
Location: 40889..104598
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C7M54_RS00175 (C7M54_00175) | - | 40889..42574 (+) | 1686 | WP_000676600.1 | recombinase family protein | - |
| C7M54_RS00180 (C7M54_00180) | tnpA | 42622..43107 (+) | 486 | WP_000093392.1 | IS200/IS605 family transposase | - |
| C7M54_RS00185 (C7M54_00185) | - | 43399..43737 (+) | 339 | WP_000175892.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| C7M54_RS00195 (C7M54_00195) | - | 43831..44142 (+) | 312 | WP_001166716.1 | DUF960 family protein | - |
| C7M54_RS00200 (C7M54_00200) | - | 44158..44664 (+) | 507 | WP_000848380.1 | DUF1643 domain-containing protein | - |
| C7M54_RS00205 (C7M54_00205) | - | 44685..45002 (+) | 318 | WP_000659046.1 | JAB domain-containing protein | - |
| C7M54_RS00210 (C7M54_00210) | - | 45121..46206 (+) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| C7M54_RS00215 (C7M54_00215) | - | 46203..48095 (+) | 1893 | Protein_37 | site-specific integrase | - |
| C7M54_RS00220 (C7M54_00220) | - | 48102..48479 (+) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| C7M54_RS00225 (C7M54_00225) | - | 48665..49030 (+) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| C7M54_RS00230 (C7M54_00230) | - | 49023..51437 (+) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| C7M54_RS00235 (C7M54_00235) | - | 51518..52135 (+) | 618 | WP_000562107.1 | CadD family cadmium resistance transporter | - |
| C7M54_RS00245 (C7M54_00245) | - | 52409..53047 (-) | 639 | Protein_42 | sulfite exporter TauE/SafE family protein | - |
| C7M54_RS00250 (C7M54_00250) | cstR | 53047..53307 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| C7M54_RS00255 (C7M54_00255) | - | 53443..54507 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| C7M54_RS00260 (C7M54_00260) | cstB | 54539..55873 (+) | 1335 | Protein_45 | persulfide dioxygenase-sulfurtransferase CstB | - |
| C7M54_RS00270 (C7M54_00270) | - | 55987..57135 (-) | 1149 | WP_000427807.1 | ROK family transcriptional regulator | - |
| C7M54_RS00275 (C7M54_00275) | psm-mec | 57455..57523 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| C7M54_RS00280 (C7M54_00280) | mecI | 57608..57979 (-) | 372 | Protein_48 | mecA-type methicillin resistance repressor MecI | - |
| C7M54_RS00285 (C7M54_00285) | mecR1 | 57979..59736 (-) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| C7M54_RS00290 (C7M54_00290) | mecA | 59833..61842 (+) | 2010 | WP_078056052.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| C7M54_RS00295 (C7M54_00295) | - | 61888..62316 (-) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| C7M54_RS00300 (C7M54_00300) | - | 62413..63156 (-) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| C7M54_RS00310 (C7M54_00310) | - | 63913..64302 (-) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| C7M54_RS00315 (C7M54_00315) | - | 64338..65012 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| C7M54_RS00320 (C7M54_00320) | - | 65101..66055 (-) | 955 | Protein_55 | replication initiation factor domain-containing protein | - |
| C7M54_RS00325 (C7M54_00325) | mobV | 66582..67823 (-) | 1242 | WP_000122374.1 | MobV family relaxase | - |
| C7M54_RS00330 (C7M54_00330) | tet(K) | 68012..69391 (-) | 1380 | WP_000492283.1 | tetracycline efflux MFS transporter Tet(K) | - |
| C7M54_RS00335 (C7M54_00335) | - | 69588..70262 (+) | 675 | WP_001106055.1 | IS6-like element IS257 family transposase | - |
| C7M54_RS00340 (C7M54_00340) | - | 70394..70636 (+) | 243 | WP_112366837.1 | LytTR family DNA-binding domain-containing protein | - |
| C7M54_RS00350 (C7M54_00350) | - | 71430..72104 (+) | 675 | WP_001105988.1 | IS6-like element IS257 family transposase | - |
| C7M54_RS00355 (C7M54_00355) | - | 72223..72738 (+) | 516 | WP_000377078.1 | hypothetical protein | - |
| C7M54_RS00365 (C7M54_00365) | merB | 72933..73583 (-) | 651 | WP_000790333.1 | organomercurial lyase MerB | - |
| C7M54_RS00370 (C7M54_00370) | merA | 73665..75308 (-) | 1644 | WP_000193219.1 | mercury(II) reductase | - |
| C7M54_RS00375 (C7M54_00375) | merT | 75366..75752 (-) | 387 | WP_001794630.1 | mercuric transport protein MerT | - |
| C7M54_RS00380 (C7M54_00380) | - | 75840..76520 (-) | 681 | WP_000010352.1 | cytochrome c biogenesis protein CcdA | - |
| C7M54_RS00385 (C7M54_00385) | - | 76517..77002 (-) | 486 | WP_000746202.1 | TlpA disulfide reductase family protein | - |
| C7M54_RS00390 (C7M54_00390) | merR | 77019..77426 (-) | 408 | WP_000525462.1 | Hg(II)-responsive transcriptional regulator MerR | - |
| C7M54_RS00395 (C7M54_00395) | - | 77726..79072 (-) | 1347 | WP_023180046.1 | NAD(P)/FAD-dependent oxidoreductase | - |
| C7M54_RS00400 (C7M54_00400) | - | 79355..80029 (+) | 675 | WP_001105987.1 | IS6-like element IS257 family transposase | - |
| C7M54_RS00405 (C7M54_00405) | - | 80091..82304 (+) | 2214 | Protein_70 | type I restriction endonuclease subunit R | - |
| C7M54_RS00410 (C7M54_00410) | - | 82384..82950 (-) | 567 | WP_000759939.1 | PepSY domain-containing protein | - |
| C7M54_RS00415 (C7M54_00415) | - | 83100..83321 (-) | 222 | WP_001070883.1 | hypothetical protein | - |
| C7M54_RS15660 | - | 83335..83499 (-) | 165 | WP_001803222.1 | hypothetical protein | - |
| C7M54_RS00420 (C7M54_00420) | - | 83788..84204 (-) | 417 | WP_000941331.1 | hypothetical protein | - |
| C7M54_RS00425 (C7M54_00425) | - | 84267..84794 (-) | 528 | WP_000717928.1 | hypothetical protein | - |
| C7M54_RS00430 (C7M54_00430) | - | 84929..85417 (-) | 489 | WP_000397419.1 | hypothetical protein | - |
| C7M54_RS00435 (C7M54_00435) | - | 85433..85723 (-) | 291 | WP_000065262.1 | hypothetical protein | - |
| C7M54_RS00440 (C7M54_00440) | - | 85780..86652 (-) | 873 | WP_000373151.1 | HTH domain-containing protein | - |
| C7M54_RS15745 (C7M54_00445) | - | 86822..86968 (-) | 147 | Protein_79 | JAB domain-containing protein | - |
| C7M54_RS00450 (C7M54_00450) | - | 87200..87862 (-) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| C7M54_RS00465 (C7M54_00465) | - | 88371..88556 (+) | 186 | Protein_81 | rRNA adenine N-6-methyltransferase family protein | - |
| C7M54_RS00470 (C7M54_00470) | erm(A) | 88567..89298 (+) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| C7M54_RS00475 (C7M54_00475) | ant(9) | 89424..90206 (-) | 783 | Protein_83 | aminoglycoside nucleotidyltransferase ANT(9) | - |
| C7M54_RS00480 (C7M54_00480) | - | 90357..90734 (-) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| C7M54_RS00485 (C7M54_00485) | - | 90741..92633 (-) | 1893 | WP_112366839.1 | site-specific integrase | - |
| C7M54_RS00490 (C7M54_00490) | - | 92827..93150 (-) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| C7M54_RS00495 (C7M54_00495) | - | 93143..93349 (-) | 207 | WP_001077283.1 | hypothetical protein | - |
| C7M54_RS00500 (C7M54_00500) | - | 93351..93872 (-) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| C7M54_RS00505 (C7M54_00505) | - | 93891..94202 (-) | 312 | WP_000833212.1 | DUF960 family protein | - |
| C7M54_RS00515 (C7M54_00515) | - | 94287..94637 (-) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| C7M54_RS00520 (C7M54_00520) | ccrB | 95108..96736 (-) | 1629 | WP_001186596.1 | recombinase family protein | Machinery gene |
| C7M54_RS00525 (C7M54_00525) | ccrA | 96757..98103 (-) | 1347 | WP_000816499.1 | recombinase family protein | Machinery gene |
| C7M54_RS00530 (C7M54_00530) | - | 98296..98571 (-) | 276 | WP_001791132.1 | hypothetical protein | - |
| C7M54_RS00535 (C7M54_00535) | - | 98661..100448 (-) | 1788 | WP_000181743.1 | DUF927 domain-containing protein | - |
| C7M54_RS00540 (C7M54_00540) | - | 100448..100732 (-) | 285 | WP_000659554.1 | DUF1413 domain-containing protein | - |
| C7M54_RS00545 (C7M54_00545) | - | 100869..101918 (+) | 1050 | WP_000613217.1 | hypothetical protein | - |
| C7M54_RS00550 (C7M54_00550) | - | 101971..102543 (+) | 573 | WP_000489177.1 | ADP-ribosyltransferase | - |
| C7M54_RS00555 (C7M54_00555) | - | 102898..104598 (+) | 1701 | WP_000649665.1 | AAA family ATPase | - |
Sequence
Protein
Download Length: 448 a.a. Molecular weight: 52138.19 Da Isoelectric Point: 10.1760
>NTDB_id=295246 C7M54_RS00525 WP_000816499.1 96757..98103(-) (ccrA) [Staphylococcus aureus strain CMRSA-3]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
Nucleotide
Download Length: 1347 bp
>NTDB_id=295246 C7M54_RS00525 WP_000816499.1 96757..98103(-) (ccrA) [Staphylococcus aureus strain CMRSA-3]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
78.174 |
100 |
0.783 |
| ccrA | Staphylococcus aureus N315 |
72.383 |
100 |
0.725 |