Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   EQH42_RS01800 Genome accession   NZ_CP035238
Coordinates   356662..357294 (+) Length   210 a.a.
NCBI ID   WP_000698434.1    Uniprot ID   Q9S1J7
Organism   Streptococcus pneumoniae strain TVO_D39     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 351662..362294
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH42_RS01775 (EQH42_01890) mvaD 351939..352892 (+) 954 WP_000373458.1 diphosphomevalonate decarboxylase -
  EQH42_RS01780 (EQH42_01895) - 352879..353886 (+) 1008 WP_000562411.1 phosphomevalonate kinase -
  EQH42_RS01785 (EQH42_01900) fni 353870..354880 (+) 1011 WP_000210629.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  EQH42_RS01790 (EQH42_01905) liaF 354958..355656 (+) 699 WP_001224634.1 cell wall-active antibiotics response protein LiaF -
  EQH42_RS01795 (EQH42_01910) - 355653..356648 (+) 996 WP_000743667.1 sensor histidine kinase -
  EQH42_RS01800 (EQH42_01915) vraR 356662..357294 (+) 633 WP_000698434.1 response regulator transcription factor Regulator
  EQH42_RS10410 (EQH42_01920) - 357295..357537 (+) 243 Protein_356 DNA alkylation repair protein -
  EQH42_RS01805 - 357462..358064 (+) 603 Protein_357 DNA alkylation repair protein -
  EQH42_RS01810 (EQH42_01935) - 358214..358408 (+) 195 WP_001819829.1 hypothetical protein -
  EQH42_RS01815 (EQH42_01940) cbpG 358534..359359 (+) 826 Protein_359 choline-binding protein CbpG -
  EQH42_RS01820 (EQH42_01945) - 359378..360262 (+) 885 WP_000771073.1 choline-binding protein CbpF -
  EQH42_RS01825 (EQH42_01950) - 360390..361536 (-) 1147 Protein_361 IS3 family transposase -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23553.03 Da        Isoelectric Point: 4.5791

>NTDB_id=295245 EQH42_RS01800 WP_000698434.1 356662..357294(+) (vraR) [Streptococcus pneumoniae strain TVO_D39]
MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIV
TSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQEEF

Nucleotide


Download         Length: 633 bp        

>NTDB_id=295245 EQH42_RS01800 WP_000698434.1 356662..357294(+) (vraR) [Streptococcus pneumoniae strain TVO_D39]
ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGTTTGGGCTTGAAAAGCTACTTTGACCTCCAAGACGATGTAGA
AGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGACTTGGCCTTGGAACTGCGTCCAGATGTCATTGTCATGGATA
TTGTCATGCCTGAGATGAATGGGATTGACGCGACCTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTATATGCTCAAGACTTCTAGTGC
AGATGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGCGAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAAT
ACCACCGCAATCATATGGAACTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
GAAAATCAGCGCATCGCAGATGACCTCTTTATCTCTCTCAAGACGGTCAAGACCCACGTGTCCAATATTCTTGCCAAACT
TGAAGTCAGCGATCGTACCCAGGCGGCTGTCTATGCCTTTCAGCACCATTTGGTGGGGCAAGAGGAGTTTTAG

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(145-199)

Response regulator receiver domain (Response_reg)

(3-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1J7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.153

99.524

0.519
  degU Bacillus subtilis subsp. subtilis str. 168

38.393

100

0.41

Multiple sequence alignment