Detailed information NTG0295169

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: CSC58_RS02430
• Genome accession: NZ_CP029681
• Coordinates: 429827..430870 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain AR_0473
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 424827..435870

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CSC58_RS02385	-	425256..425366 (+)	111	WP_001790257.1	hypothetical protein	-
CSC58_RS02390 (CSC58_0445)	-	425395..425808 (+)	414	WP_025173836.1	hypothetical protein	-
CSC58_RS02400 (CSC58_0446)	-	426239..427225 (-)	987	WP_000999714.1	aromatic acid exporter family protein	-
CSC58_RS02415 (CSC58_0447)	map	427753..428511 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
CSC58_RS02420 (CSC58_0448)	-	428728..429114 (+)	387	WP_001110179.1	hypothetical protein	-
CSC58_RS02425 (CSC58_0449)	liaF	429129..429830 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
CSC58_RS02430 (CSC58_0450)	vraS	429827..430870 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
CSC58_RS02435 (CSC58_0451)	vraR	430860..431489 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
CSC58_RS02440 (CSC58_0452)	-	431601..432818 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
CSC58_RS02445 (CSC58_0453)	-	433096..433371 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
CSC58_RS02450 (CSC58_0454)	-	433378..433842 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
CSC58_RS02455 (CSC58_0455)	-	433989..434189 (+)	201	WP_000180460.1	DUF1128 family protein	-
CSC58_RS02460 (CSC58_0456)	-	434192..435448 (+)	1257	WP_001789555.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=295169 CSC58_RS02430 WP_001017131.1 429827..430870(+) (vraS) [Staphylococcus aureus strain AR_0473]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=295169 CSC58_RS02430 WP_001017131.1 429827..430870(+) (vraS) [Staphylococcus aureus strain AR_0473]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1