Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   CSC58_RS02435 Genome accession   NZ_CP029681
Coordinates   430860..431489 (+) Length   209 a.a.
NCBI ID   WP_000153530.1    Uniprot ID   D9IFM7
Organism   Staphylococcus aureus strain AR_0473     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 425860..436489
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CSC58_RS02400 (CSC58_0446) - 426239..427225 (-) 987 WP_000999714.1 aromatic acid exporter family protein -
  CSC58_RS02415 (CSC58_0447) map 427753..428511 (+) 759 WP_000636142.1 type I methionyl aminopeptidase -
  CSC58_RS02420 (CSC58_0448) - 428728..429114 (+) 387 WP_001110179.1 hypothetical protein -
  CSC58_RS02425 (CSC58_0449) liaF 429129..429830 (+) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  CSC58_RS02430 (CSC58_0450) vraS 429827..430870 (+) 1044 WP_001017131.1 sensor histidine kinase Regulator
  CSC58_RS02435 (CSC58_0451) vraR 430860..431489 (+) 630 WP_000153530.1 two-component system response regulator VraR Regulator
  CSC58_RS02440 (CSC58_0452) - 431601..432818 (-) 1218 WP_000037079.1 YihY/virulence factor BrkB family protein -
  CSC58_RS02445 (CSC58_0453) - 433096..433371 (-) 276 WP_000428172.1 YtxH domain-containing protein -
  CSC58_RS02450 (CSC58_0454) - 433378..433842 (-) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  CSC58_RS02455 (CSC58_0455) - 433989..434189 (+) 201 WP_000180460.1 DUF1128 family protein -
  CSC58_RS02460 (CSC58_0456) - 434192..435448 (+) 1257 WP_001789555.1 aminopeptidase -
  CSC58_RS02465 (CSC58_0457) - 435538..436068 (+) 531 WP_000184383.1 acyl-CoA thioesterase -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23545.29 Da        Isoelectric Point: 5.3889

>NTDB_id=295170 CSC58_RS02435 WP_000153530.1 430860..431489(+) (vraR) [Staphylococcus aureus strain AR_0473]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMDDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=295170 CSC58_RS02435 WP_000153530.1 430860..431489(+) (vraR) [Staphylococcus aureus strain AR_0473]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGATGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTCATCTATGCATTCCAACATAATTTAATTCAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-116)

Bacterial regulatory proteins, luxR family (GerE)

(147-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB D9IFM7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

99.522

100

0.995
  degU Bacillus subtilis subsp. subtilis str. 168

34.821

100

0.373

Multiple sequence alignment