Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   EQH44_RS01945 Genome accession   NZ_CP035236
Coordinates   382140..382772 (+) Length   210 a.a.
NCBI ID   WP_000698434.1    Uniprot ID   Q9S1J7
Organism   Streptococcus pneumoniae strain TVO_1902282     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 377140..387772
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH44_RS01920 (EQH44_02060) mvaD 377417..378370 (+) 954 WP_000373457.1 diphosphomevalonate decarboxylase -
  EQH44_RS01925 (EQH44_02065) - 378357..379364 (+) 1008 WP_000562412.1 phosphomevalonate kinase -
  EQH44_RS01930 (EQH44_02070) fni 379348..380358 (+) 1011 WP_000210618.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  EQH44_RS01935 (EQH44_02075) liaF 380436..381134 (+) 699 WP_001224637.1 cell wall-active antibiotics response protein LiaF -
  EQH44_RS01940 (EQH44_02080) - 381131..382126 (+) 996 WP_000743682.1 sensor histidine kinase -
  EQH44_RS01945 (EQH44_02085) vraR 382140..382772 (+) 633 WP_000698434.1 response regulator transcription factor Regulator
  EQH44_RS10685 (EQH44_02090) - 382773..383015 (+) 243 Protein_389 DNA alkylation repair protein -
  EQH44_RS01950 - 382940..383542 (+) 603 Protein_390 DNA alkylation repair protein -
  EQH44_RS01955 (EQH44_02105) - 383692..383931 (+) 240 WP_000754501.1 hypothetical protein -
  EQH44_RS01960 (EQH44_02110) cbpG 384012..384837 (+) 826 Protein_392 choline-binding protein CbpG -
  EQH44_RS01965 (EQH44_02115) cbpF 384856..385878 (+) 1023 Protein_393 choline-binding protein CbpF -
  EQH44_RS01970 (EQH44_02120) - 386006..387141 (-) 1136 Protein_394 IS3 family transposase -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23553.03 Da        Isoelectric Point: 4.5791

>NTDB_id=295014 EQH44_RS01945 WP_000698434.1 382140..382772(+) (vraR) [Streptococcus pneumoniae strain TVO_1902282]
MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIV
TSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQEEF

Nucleotide


Download         Length: 633 bp        

>NTDB_id=295014 EQH44_RS01945 WP_000698434.1 382140..382772(+) (vraR) [Streptococcus pneumoniae strain TVO_1902282]
ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGTTTGGGCTTGAAAAGCTACTTTGACCTCCAAGACGATGTAGA
AGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGACTTGGCCTTGGAACTGCGTCCAGATGTCATTGTCATGGATA
TTGTCATGCCTGAGATGAATGGGATTGACGCGACCTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTATATGCTCAAGACTTCTAGTGC
AGATGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGCGAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAAT
ACCACCGCAATCATATGGAACTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
GAAAATCAGCGCATCGCAGATGACCTCTTTATCTCTCTCAAGACGGTCAAGACCCACGTGTCCAATATTCTTGCCAAACT
TGAAGTCAGCGATCGTACCCAGGCGGCTGTCTATGCCTTTCAGCACCATTTGGTGGGGCAAGAGGAGTTTTAG

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(145-199)

Response regulator receiver domain (Response_reg)

(3-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1J7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.153

99.524

0.519
  degU Bacillus subtilis subsp. subtilis str. 168

38.393

100

0.41