Detailed information NTG0294814

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: CSB84_RS10840
• Genome accession: NZ_CP029663
• Coordinates: 2032525..2033568 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain AR_0228
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2027525..2038568

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CSB84_RS10810 (CSB84_1986)	-	2027946..2029202 (-)	1257	WP_001795108.1	aminopeptidase	-
CSB84_RS10815 (CSB84_1987)	-	2029205..2029405 (-)	201	WP_000180460.1	DUF1128 family protein	-
CSB84_RS10820 (CSB84_1988)	-	2029552..2030016 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
CSB84_RS10825 (CSB84_1989)	-	2030023..2030298 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
CSB84_RS10830 (CSB84_1990)	-	2030576..2031793 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
CSB84_RS10835 (CSB84_1991)	vraR	2031906..2032535 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
CSB84_RS10840 (CSB84_1992)	vraS	2032525..2033568 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
CSB84_RS10845 (CSB84_1993)	liaF	2033565..2034266 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
CSB84_RS10850 (CSB84_1994)	-	2034281..2034667 (-)	387	WP_001110179.1	hypothetical protein	-
CSB84_RS10855 (CSB84_1995)	map	2034884..2035642 (-)	759	WP_000636140.1	type I methionyl aminopeptidase	-
CSB84_RS10865 (CSB84_1996)	-	2036173..2037159 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
CSB84_RS10875 (CSB84_1997)	-	2037590..2038003 (-)	414	WP_001557448.1	hypothetical protein	-
CSB84_RS10880	-	2038032..2038142 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=294814 CSB84_RS10840 WP_001017131.1 2032525..2033568(-) (vraS) [Staphylococcus aureus strain AR_0228]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=294814 CSB84_RS10840 WP_001017131.1 2032525..2033568(-) (vraS) [Staphylococcus aureus strain AR_0228]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1