Detailed information NTG0294701

Bioinformatically predicted

Overview

• Name: ccrB
• Type: Machinery gene
• Locus tag: CSC52_RS00340
• Genome accession: NZ_CP029658
• Coordinates: 75140..76768 (+)
• Length: 542 a.a.
• NCBI ID: WP_001186602.1
• Uniprot ID: Q9XB94
• Organism: Staphylococcus aureus strain AR_0467
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	73769..95108	75140..76768	within	0

Gene organization within MGE regions

Location: 73769..95108

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CSC52_RS00335 (CSC52_0063)	ccrA	73769..75118 (+)	1350	WP_000815646.1	recombinase family protein	Machinery gene
CSC52_RS00340 (CSC52_0064)	ccrB	75140..76768 (+)	1629	WP_001186602.1	recombinase family protein	Machinery gene
CSC52_RS00345 (CSC52_0065)	-	77286..77636 (+)	351	WP_000859155.1	SAUGI family uracil-DNA glycosylase inhibitor	-
CSC52_RS00350 (CSC52_0066)	-	77723..78034 (+)	312	WP_000700853.1	DUF960 family protein	-
CSC52_RS00355 (CSC52_0067)	-	78052..78558 (+)	507	WP_001092169.1	DUF1643 domain-containing protein	-
CSC52_RS00360 (CSC52_0068)	-	78579..78896 (+)	318	WP_000659050.1	JAB domain-containing protein	-
CSC52_RS00365 (CSC52_0069)	-	79015..80100 (+)	1086	WP_000868132.1	tyrosine-type recombinase/integrase	-
CSC52_RS00370 (CSC52_0071)	-	80097..81989 (+)	1893	Protein_69	site-specific integrase	-
CSC52_RS00375 (CSC52_0072)	-	81996..82373 (+)	378	WP_000361059.1	DUF6262 family protein	-
CSC52_RS00380 (CSC52_0073)	-	82524..83306 (+)	783	WP_000067268.1	aminoglycoside nucleotidyltransferase ANT(9)-Ia	-
CSC52_RS00385 (CSC52_0074)	erm(A)	83432..84163 (-)	732	WP_001072201.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	-
CSC52_RS00400 (CSC52_0076)	-	84672..85333 (+)	662	Protein_73	class I SAM-dependent methyltransferase	-
CSC52_RS00410 (CSC52_0077)	-	85678..86316 (-)	639	Protein_74	sulfite exporter TauE/SafE family protein	-
CSC52_RS00415 (CSC52_0078)	cstR	86316..86576 (-)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
CSC52_RS00420 (CSC52_0079)	-	86712..87776 (+)	1065	WP_000438836.1	DsrE/DsrF/DrsH-like family protein	-
CSC52_RS00425 (CSC52_0080)	cstB	87809..89143 (+)	1335	Protein_77	persulfide dioxygenase-sulfurtransferase CstB	-
CSC52_RS00435 (CSC52_0082)	-	89257..90387 (-)	1131	WP_010922808.1	ROK family transcriptional regulator	-
CSC52_RS00440	psm-mec	90721..90789 (+)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
CSC52_RS00445 (CSC52_0083)	mecI	90874..91245 (-)	372	WP_000369214.1	mecA-type methicillin resistance repressor MecI	-
CSC52_RS00450 (CSC52_0084)	mecR1	91245..93002 (-)	1758	WP_108720631.1	beta-lactam sensor/signal transducer MecR1	-
CSC52_RS00455 (CSC52_0085)	mecA	93099..95108 (+)	2010	WP_110184127.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-

Sequence

Protein

• Length: 542 a.a.
• Molecular weight: 62664.84 Da
• Isoelectric Point: 9.8600

>NTDB_id=294701 CSC52_RS00340 WP_001186602.1 75140..76768(+) (ccrB) [Staphylococcus aureus strain AR_0467]
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRILKDAKEGYIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPNSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEDYVMKQILEIVKSDKVIQRVVTHVNQENQVDGAALHHDIAYKQQQYD
EVQIKLNNLIKTIEDNPDLTSVIRPSIQKYEKQLNDITNQINQLKNQQNEDKPLFDAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI

Nucleotide

• Length: 1629 bp

>NTDB_id=294701 CSC52_RS00340 WP_001186602.1 75140..76768(+) (ccrB) [Staphylococcus aureus strain AR_0467]
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTATCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAAGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAATCGACCTGAGCTCCAACGTATATTGAAGGATGCGAAAGAAGGCTATATCGACTGTGTTATG
GTCTACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTATCAGAGCGTATGGAAGTCAATACTTCATCGGGTAAGCTCATGTTACAAATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAATGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCTAATAGTAAACATGAACTGATGATTAATCAACATGAAGCTAATATTGTGAAATA
TATATTCGAGTCCTATGCCAAAGGCCATGGCTATCGTAAAATAGCCAATGCATTAAATCACAAAGGCTATGTCACTAAAA
AGGGTAAACCTTTTAGTATTAGTTCTATCACATATATATTAGCTAACCCATTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTTAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAAAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCCCAATGTGGCGCACCTATGGCAGCAAGCAATACCACGAATACACTTAAAGAC
GGGACTAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGTTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGTGATTGAAGATTATGTGATGAAGCAAATACTTGAAATAGTCAAAAGTGATAAAGTCATTCAACGCGTAG
TAACACACGTCAATCAAGAAAATCAAGTTGATGGCGCTGCACTTCATCACGATATTGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAACTAAATAACTTGATTAAAACCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTACGAATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGCCTT
TATTTGATGCCAAAGAAATCAGTAAACTATTACAACACATCTTTCATGATATTAAGCACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACAATTCTATGTCACACTCAA
ACTTAATAACGAAATCATAAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTGTTTT
TGCCCCAAACACTATATCTTACTATTTAG

Domains

Predicted by InterproScan.

• Ogr/Delta-like zinc finger (Ogr_Delta) (301-356)

• Resolvase, N terminal domain (Resolvase) (11-156)

• Recombinase (Recombinase) (180-280)

3D structure

• AlphaFold DB: Q9XB94

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrB	Staphylococcus aureus N315	100	100	1