Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   DLJ52_RS02445 Genome accession   NZ_CP029559
Coordinates   465363..467465 (+) Length   700 a.a.
NCBI ID   WP_002960430.1    Uniprot ID   -
Organism   Streptococcus sobrinus strain NIDR 6715-15     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 458421..515969 465363..467465 within 0


Gene organization within MGE regions


Location: 458421..515969
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DLJ52_RS02400 (DLJ52_02400) rsfS 458484..458837 (+) 354 WP_109982442.1 ribosome silencing factor -
  DLJ52_RS02405 (DLJ52_02405) - 458884..459621 (+) 738 WP_019777410.1 class I SAM-dependent methyltransferase -
  DLJ52_RS02410 (DLJ52_02410) - 459814..460911 (+) 1098 WP_019777409.1 nucleotidyltransferase -
  DLJ52_RS02415 (DLJ52_02415) - 460916..461161 (+) 246 WP_019777408.1 hypothetical protein -
  DLJ52_RS02420 (DLJ52_02420) - 461226..462605 (+) 1380 WP_094966497.1 hypothetical protein -
  DLJ52_RS02425 (DLJ52_02425) - 462789..463403 (+) 615 WP_019777900.1 MerR family transcriptional regulator -
  DLJ52_RS02430 (DLJ52_02430) - 463509..463862 (+) 354 Protein_429 IS3 family transposase -
  DLJ52_RS02435 (DLJ52_02435) - 463946..464881 (-) 936 WP_109982396.1 IS30 family transposase -
  DLJ52_RS02445 (DLJ52_02445) clpC 465363..467465 (+) 2103 WP_002960430.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  DLJ52_RS02450 (DLJ52_02450) - 467899..468744 (+) 846 WP_002960429.1 SDR family oxidoreductase -
  DLJ52_RS02455 (DLJ52_02455) dhaM 468977..469351 (-) 375 WP_019781567.1 dihydroxyacetone kinase phosphoryl donor subunit DhaM -
  DLJ52_RS02460 (DLJ52_02460) dhaL 469352..469930 (-) 579 WP_019795624.1 dihydroxyacetone kinase subunit DhaL -
  DLJ52_RS02465 (DLJ52_02465) dhaK 469969..470958 (-) 990 WP_019768867.1 dihydroxyacetone kinase subunit DhaK -
  DLJ52_RS02470 (DLJ52_02470) - 471387..472106 (+) 720 WP_019768868.1 YebC/PmpR family DNA-binding transcriptional regulator -
  DLJ52_RS02475 (DLJ52_02475) - 472209..473561 (-) 1353 Protein_437 MFS transporter -
  DLJ52_RS02480 (DLJ52_02480) - 473730..474827 (+) 1098 WP_019785414.1 DUF5937 family protein -
  DLJ52_RS02485 (DLJ52_02485) - 474846..475376 (+) 531 WP_109982443.1 transcriptional regulator -
  DLJ52_RS02490 (DLJ52_02490) - 475580..476239 (+) 660 WP_002960420.1 CBS domain-containing protein -
  DLJ52_RS02495 (DLJ52_02495) tmk 476368..477021 (+) 654 WP_109982444.1 dTMP kinase -
  DLJ52_RS02500 (DLJ52_02500) - 477024..477887 (+) 864 WP_002960415.1 DNA polymerase III subunit delta' -
  DLJ52_RS02505 (DLJ52_02505) - 477884..478684 (+) 801 WP_019768874.1 regulatory iron-sulfur-containing complex subunit RicT -
  DLJ52_RS02510 (DLJ52_02510) yabA 478677..478997 (+) 321 WP_002960412.1 DNA replication initiation control protein YabA -
  DLJ52_RS02515 (DLJ52_02515) rsmI 479001..479867 (+) 867 WP_109982445.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
  DLJ52_RS02520 (DLJ52_02520) - 480087..481322 (+) 1236 WP_109982446.1 ammonium transporter -
  DLJ52_RS02525 (DLJ52_02525) - 481390..481731 (+) 342 WP_019769579.1 P-II family nitrogen regulator -
  DLJ52_RS02530 (DLJ52_02530) acnA 481953..484634 (+) 2682 WP_109982447.1 aconitate hydratase AcnA -
  DLJ52_RS02535 (DLJ52_02535) - 484676..485794 (+) 1119 WP_109982448.1 citrate synthase -
  DLJ52_RS02540 (DLJ52_02540) icd 485799..486980 (+) 1182 WP_109982449.1 NADP-dependent isocitrate dehydrogenase -
  DLJ52_RS02545 (DLJ52_02545) serC 487538..488632 (+) 1095 WP_109982450.1 3-phosphoserine/phosphohydroxythreonine transaminase -
  DLJ52_RS02550 (DLJ52_02550) - 488672..489220 (+) 549 WP_109982451.1 GNAT family N-acetyltransferase -
  DLJ52_RS02555 (DLJ52_02555) - 489552..490730 (+) 1179 WP_109982452.1 3-phosphoglycerate dehydrogenase family protein -
  DLJ52_RS02560 (DLJ52_02560) - 490807..491037 (+) 231 WP_019770871.1 DUF6440 family protein -
  DLJ52_RS02565 (DLJ52_02565) - 491034..491567 (+) 534 WP_109982453.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
  DLJ52_RS02570 (DLJ52_02570) - 491542..491898 (+) 357 WP_109982454.1 arsenate reductase family protein -
  DLJ52_RS02575 (DLJ52_02575) - 492013..492876 (+) 864 WP_109982455.1 Rgg/GadR/MutR family transcriptional regulator -
  DLJ52_RS02580 (DLJ52_02580) tnpA 493188..493643 (+) 456 Protein_458 IS200/IS605 family transposase -
  DLJ52_RS10420 - 494105..494254 (+) 150 WP_162564131.1 hypothetical protein -
  DLJ52_RS02590 (DLJ52_02590) - 494814..496421 (+) 1608 WP_109982457.1 ABC transporter ATP-binding protein -
  DLJ52_RS02595 (DLJ52_02595) lanKC 496488..499115 (+) 2628 WP_109982458.1 class III lanthionine synthetase LanKC -
  DLJ52_RS02600 (DLJ52_02600) - 499151..500419 (+) 1269 WP_109982459.1 hypothetical protein -
  DLJ52_RS02605 (DLJ52_02605) - 500479..501114 (+) 636 WP_269460245.1 prolyl oligopeptidase family serine peptidase -
  DLJ52_RS02610 (DLJ52_02610) - 501188..501868 (+) 681 WP_230307012.1 ABC transporter ATP-binding protein -
  DLJ52_RS02615 (DLJ52_02615) - 501882..503189 (+) 1308 WP_109982462.1 FtsX-like permease family protein -
  DLJ52_RS02620 (DLJ52_02620) - 503257..504588 (+) 1332 WP_109982463.1 YqiA/YcfP family alpha/beta fold hydrolase -
  DLJ52_RS02625 (DLJ52_02625) - 504666..505496 (-) 831 WP_109982807.1 exodeoxyribonuclease III -
  DLJ52_RS02630 (DLJ52_02630) - 505691..506945 (+) 1255 Protein_468 NRAMP family divalent metal transporter -
  DLJ52_RS02635 (DLJ52_02635) - 507005..507358 (-) 354 WP_002961857.1 DUF3397 domain-containing protein -
  DLJ52_RS02640 (DLJ52_02640) rplK 507640..508065 (+) 426 WP_002961855.1 50S ribosomal protein L11 -
  DLJ52_RS02645 (DLJ52_02645) rplA 508160..508849 (+) 690 WP_002961854.1 50S ribosomal protein L1 -
  DLJ52_RS02650 (DLJ52_02650) pyrH 509060..509791 (+) 732 WP_003001144.1 UMP kinase -
  DLJ52_RS02655 (DLJ52_02655) frr 509810..510367 (+) 558 WP_002961851.1 ribosome recycling factor -
  DLJ52_RS02660 (DLJ52_02660) - 510432..511286 (+) 855 WP_019785388.1 S1 RNA-binding domain-containing protein -
  DLJ52_RS02665 (DLJ52_02665) - 511298..511861 (+) 564 WP_021673831.1 GrpB family protein -
  DLJ52_RS02670 (DLJ52_02670) - 512155..512982 (+) 828 WP_021673830.1 amino acid ABC transporter substrate-binding protein -
  DLJ52_RS02675 (DLJ52_02675) - 513965..514852 (+) 888 WP_002959057.1 MetQ/NlpA family ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 700 a.a.        Molecular weight: 76612.38 Da        Isoelectric Point: 4.8082

>NTDB_id=293513 DLJ52_RS02445 WP_002960430.1 465363..467465(+) (clpC) [Streptococcus sobrinus strain NIDR 6715-15]
MNNNFGFNNMDDIFNQLMGNMGGFNSETRRYRINGREVTPEEFNYYRQTGHLPNQEAIQDGASQANQGQIKQGGILANLG
RNLTEEARQGKLDPVIGRNQEIQDTAEILARRTKNNPVLVGDAGVGKTAVVEGLAQAIVAGDVPAAIKNKEIISIDISGL
EAGTQYRGAFEENIQKLMDEVKQAGNIILFFDEIHQILGAGSTGDGQGSKGLADIIKPALSRGELTVIGATTQDEYRNTI
LKNAALARRFNEVKVNAPSAEDTFAILQGIKPLYEQHHNVELPDSVLKAAVDYSIQYMPQRALPDKAIDLVDVTAAHLAA
QHPATDVKTLEAGIAKARDRQQAAADKEDYEAALAEKVKIDDLQKQIDNHTENQKVVATVNDVAQAVERMTGIPVSQMGA
SDIERLKEMGSRLKGKVIGQDEAVQAVSKAIRRNRAGFDEGNRPIGSFLFVGPTGVGKTELAKQLALDMFGTKDAVIRLD
MSEYSDRTAVSKLIGTTAGYVGYDDNSNTLTERVRRNPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTVNFKNT
VIIATSNAGYSFGAVPEEDGKEVSLRDKLAPFFRPEFLNRFNGVIEFSHLSKEDLQEIVDLMLDEVNRTLAKKGLTLEVS
DAAKAYLIEEGYDEAMGARPLRRVIEGQIRDKVTDFYLDHLDVKALKADMVDGKLVISQA

Nucleotide


Download         Length: 2103 bp        

>NTDB_id=293513 DLJ52_RS02445 WP_002960430.1 465363..467465(+) (clpC) [Streptococcus sobrinus strain NIDR 6715-15]
ATGAACAACAATTTTGGATTTAACAATATGGACGATATTTTCAATCAACTGATGGGTAACATGGGCGGTTTCAATTCAGA
AACTCGTCGCTACCGCATCAATGGTCGAGAAGTCACTCCGGAAGAATTTAACTACTATCGCCAAACTGGTCACCTGCCTA
ATCAAGAAGCAATCCAAGACGGGGCTTCCCAAGCAAACCAAGGGCAAATCAAGCAAGGTGGTATCCTGGCTAATCTGGGG
CGTAACCTGACAGAAGAAGCTCGCCAAGGCAAGCTGGATCCTGTTATCGGTCGGAACCAAGAAATTCAAGATACAGCAGA
AATCTTGGCTCGTCGGACCAAGAATAATCCTGTCCTAGTCGGTGATGCTGGTGTTGGTAAGACAGCGGTTGTTGAAGGCT
TGGCCCAAGCTATTGTCGCAGGTGATGTGCCTGCTGCTATCAAGAACAAGGAAATTATCAGCATTGATATTTCAGGTCTG
GAAGCTGGTACCCAATATCGTGGGGCATTTGAAGAAAACATTCAAAAGCTGATGGATGAAGTCAAACAAGCAGGTAATAT
CATTCTCTTCTTTGATGAAATTCACCAAATCTTGGGTGCTGGTAGTACTGGTGATGGTCAAGGCTCTAAGGGTTTGGCCG
ACATTATCAAGCCTGCCCTCTCTCGTGGTGAGCTAACCGTGATTGGGGCAACGACCCAAGATGAATACCGTAACACCATT
TTGAAGAATGCAGCTCTGGCTCGTCGTTTCAATGAAGTTAAGGTCAATGCTCCTTCGGCAGAAGATACCTTCGCTATCCT
GCAAGGGATTAAGCCCCTCTATGAACAACACCACAATGTGGAATTGCCAGATAGTGTTTTGAAGGCTGCGGTGGATTATT
CTATCCAATATATGCCCCAAAGGGCCCTGCCTGACAAGGCTATTGACTTGGTCGATGTGACGGCGGCCCACTTGGCAGCT
CAACATCCAGCAACCGATGTTAAGACCTTGGAAGCTGGTATTGCTAAAGCACGTGACCGCCAACAAGCTGCAGCTGATAA
GGAAGATTACGAAGCAGCTCTGGCTGAAAAAGTAAAGATTGATGACTTGCAAAAACAAATTGACAACCATACCGAAAATC
AAAAGGTTGTGGCGACAGTCAATGATGTGGCTCAAGCGGTTGAACGGATGACTGGTATTCCTGTTTCACAAATGGGGGCC
AGCGACATTGAACGCTTGAAAGAAATGGGTAGTCGCCTGAAAGGCAAGGTTATCGGTCAAGATGAGGCAGTTCAAGCCGT
CAGCAAGGCTATTCGTCGGAACCGAGCTGGTTTTGATGAAGGTAATCGCCCAATCGGTAGCTTCCTCTTCGTCGGACCTA
CTGGGGTTGGTAAGACCGAATTGGCTAAGCAATTGGCCCTGGATATGTTTGGTACCAAGGATGCCGTTATTCGCTTGGAT
ATGTCTGAATATAGCGACCGGACGGCTGTTTCTAAATTGATTGGTACGACTGCTGGTTATGTGGGTTACGATGACAATTC
CAACACTTTGACCGAACGGGTTCGTCGCAATCCTTATTCTATTATCCTCCTTGATGAAATCGAAAAGGCTGACCCACAAG
TCATCACCTTGCTTTTGCAAGTTTTGGACGATGGTCGCCTGACCGATGGTCAAGGCAACACCGTCAACTTCAAGAATACT
GTGATTATCGCCACCTCTAATGCTGGCTATAGCTTTGGTGCTGTGCCAGAAGAAGATGGTAAGGAAGTTAGTCTGCGAGA
TAAATTAGCACCATTCTTCCGTCCAGAATTCCTTAACCGCTTCAACGGGGTTATCGAGTTCTCTCATTTATCTAAAGAAG
ATTTGCAGGAAATTGTTGACTTGATGCTGGATGAAGTCAACCGCACCTTGGCCAAGAAGGGTTTGACCTTGGAAGTCAGC
GATGCGGCTAAGGCTTACCTGATTGAAGAAGGTTACGATGAAGCCATGGGAGCACGGCCTCTGCGTCGGGTCATCGAAGG
CCAAATTCGTGACAAGGTCACCGACTTCTATCTGGATCATCTGGATGTCAAAGCTCTCAAGGCCGATATGGTTGACGGTA
AGTTAGTCATTTCTCAAGCCTAA

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(610-680)

ATPase family associated with various cellular activities (AAA) (AAA)

(118-250)

AAA domain (Cdc48 subfamily) (AAA_2)

(443-602)

AAA lid domain (AAA_lid_9)

(259-352)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Lactococcus lactis subsp. cremoris KW2

49.222

100

0.497
  clpE Streptococcus mutans UA159

51.944

91.857

0.477
  clpE Streptococcus pneumoniae Rx1

46.733

100

0.47
  clpE Streptococcus pneumoniae D39

46.733

100

0.47
  clpE Streptococcus pneumoniae R6

46.733

100

0.47
  clpE Streptococcus pneumoniae TIGR4

49.843

90.857

0.453
  clpC Bacillus subtilis subsp. subtilis str. 168

45.866

91.571

0.42
  clpC Streptococcus pneumoniae Rx1

42.969

91.429

0.393
  clpC Streptococcus pneumoniae D39

42.969

91.429

0.393
  clpC Streptococcus thermophilus LMD-9

43.103

91.143

0.393
  clpC Streptococcus pneumoniae TIGR4

43.014

91

0.391
  clpC Streptococcus thermophilus LMG 18311

42.79

91.143

0.39
  clpC Streptococcus mutans UA159

43.178

89

0.384
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

41.842

88.429

0.37

Multiple sequence alignment