Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrB   Type   Machinery gene
Locus tag   CSC51_RS02550 Genome accession   NZ_CP029080
Coordinates   489129..490757 (-) Length   542 a.a.
NCBI ID   WP_061642462.1    Uniprot ID   -
Organism   Staphylococcus aureus strain AR466     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 489428..513142 489129..490757 flank -1329


Gene organization within MGE regions


Location: 489129..513142
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CSC51_RS02550 (CSC51_0440) ccrB 489129..490757 (-) 1629 WP_061642462.1 recombinase family protein Machinery gene
  CSC51_RS02555 (CSC51_0441) ccrA 490754..492115 (-) 1362 WP_061544228.1 recombinase family protein Machinery gene
  CSC51_RS02560 (CSC51_0442) - 492326..494092 (-) 1767 WP_061544227.1 DUF927 domain-containing protein -
  CSC51_RS02565 (CSC51_0443) - 494092..494385 (-) 294 WP_046464617.1 hypothetical protein -
  CSC51_RS02570 (CSC51_0444) - 494556..496070 (-) 1515 WP_108703122.1 hypothetical protein -
  CSC51_RS02575 (CSC51_0445) - 496701..497612 (+) 912 WP_046464619.1 ABC transporter substrate-binding protein -
  CSC51_RS14470 (CSC51_0446) - 497645..497815 (-) 171 WP_155734542.1 hypothetical protein -
  CSC51_RS02580 - 497862..498523 (-) 662 Protein_463 IS6 family transposase -
  CSC51_RS02585 (CSC51_0448) - 498637..499593 (+) 957 WP_000282655.1 thymidylate synthase -
  CSC51_RS02590 (CSC51_0449) - 499635..500120 (+) 486 WP_000175735.1 trimethoprim-resistant dihydrofolate reductase DfrS1 -
  CSC51_RS02595 (CSC51_0450) - 500130..500528 (+) 399 Protein_466 DegV family protein -
  CSC51_RS02600 (CSC51_0451) - 500584..501258 (-) 675 WP_001106019.1 IS6-like element IS257 family transposase -
  CSC51_RS02605 - 501342..501683 (+) 342 WP_001797647.1 hydroxymethylglutaryl-CoA synthase -
  CSC51_RS02615 (CSC51_0453) - 502560..503303 (+) 744 WP_000958858.1 glycerophosphoryl diester phosphodiesterase -
  CSC51_RS02620 (CSC51_0454) - 503400..503828 (+) 429 WP_000872606.1 MaoC family dehydratase -
  CSC51_RS02625 (CSC51_0455) mecA 503874..505883 (-) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  CSC51_RS02630 (CSC51_0456) - 505980..506966 (+) 987 WP_001549960.1 beta-lactam sensor/signal transducer MecR1 -
  CSC51_RS02635 (CSC51_0457) - 506938..507198 (+) 261 WP_001549961.1 type I restriction enzyme endonuclease domain-containing protein -
  CSC51_RS02640 (CSC51_0458) - 507189..508796 (-) 1608 Protein_474 IS1182 family transposase -
  CSC51_RS02645 (CSC51_0459) - 508848..509354 (-) 507 WP_001092195.1 DUF1643 domain-containing protein -
  CSC51_RS02650 (CSC51_0460) - 509369..509680 (-) 312 WP_001024803.1 DUF960 family protein -
  CSC51_RS02660 (CSC51_0461) - 509767..510117 (-) 351 WP_070508371.1 SAUGI family uracil-DNA glycosylase inhibitor -
  CSC51_RS02665 (CSC51_0462) - 510800..511390 (-) 591 WP_070508372.1 hypothetical protein -
  CSC51_RS02670 (CSC51_0463) ccrB 511517..513142 (-) 1626 WP_108703123.1 recombinase family protein Machinery gene

Sequence

Protein


Download         Length: 542 a.a.        Molecular weight: 62339.47 Da        Isoelectric Point: 9.5866

>NTDB_id=290111 CSC51_RS02550 WP_061642462.1 489129..490757(-) (ccrB) [Staphylococcus aureus strain AR466]
MTQLKKKRIGLYARVSTEMQTDGYSIHGQLNQLTEYCQFQGYEVVDEYTDRGISGKTTQRPELQRMLKDAKGGKLDGIMV
YNTTRLARNTSDLLNIVEELYEINVEFFSLTEKIEIASSTGKLMLQILASFAEFERNVIVENVFNGQRQRAIEGYYQGNL
PLGYDKVPESKKELMINQHEANIVKYIFESYAKGHGYRKIANTLNHKGYVTKKGKPFSISSITYIISNPFYIGKIQFAKY
RHWSDKRRKGLNEEPIIADGKHAPIIDKALWDKVQFKRQESRKKPQVHGKGTNLLTGIVKCPKCGAAMAASNTTNTLKDG
TKKRIRYYSCSNFRNKGSKVCSANSVRADVLEKYVMDQILEIIKSKKVLKQLVEKVNEQSQIDKSSLNHDIAYKQSQCEE
LKAKMHTLTKTIEDSPDLDSVLKPTILNYQDELNQINNQIHQLEQDKQAEAPHYDADMIANVLQAIFKDIDKLEKSQLKS
LYLTVIDRIDIRNHEHHKKQFYVTLKLNNEIIKQLFNNRPLDEVLLSTSSLFLPQTIYITIE

Nucleotide


Download         Length: 1629 bp        

>NTDB_id=290111 CSC51_RS02550 WP_061642462.1 489129..490757(-) (ccrB) [Staphylococcus aureus strain AR466]
ATGACACAACTCAAAAAGAAACGTATTGGATTATACGCACGTGTATCAACTGAAATGCAAACGGATGGTTACAGTATCCA
TGGTCAATTAAATCAACTTACAGAGTATTGTCAATTTCAAGGTTATGAAGTCGTTGATGAATATACCGATCGTGGTATAT
CAGGTAAAACAACGCAACGTCCTGAACTACAACGTATGTTAAAAGATGCTAAAGGAGGTAAATTAGATGGTATTATGGTA
TATAATACTACTCGTTTAGCTAGAAATACCTCAGATTTATTAAATATTGTCGAAGAATTGTATGAGATTAATGTTGAATT
TTTTAGTCTAACTGAAAAAATAGAAATTGCGAGCTCCACAGGTAAGTTGATGCTCCAAATCTTAGCGAGCTTCGCAGAAT
TTGAAAGAAACGTTATTGTAGAAAACGTGTTTAATGGCCAAAGACAACGTGCTATTGAAGGTTATTACCAAGGTAATTTA
CCTTTAGGCTATGATAAAGTACCTGAGAGTAAAAAAGAGCTTATGATTAATCAACATGAAGCAAATATTGTTAAATATAT
TTTTGAGTCATACGCCAAAGGTCACGGTTATCGTAAGATTGCGAACACATTGAATCATAAAGGTTATGTGACTAAGAAAG
GGAAACCGTTTAGTATTTCGTCCATTACTTATATCATCTCAAACCCTTTTTACATTGGAAAGATACAGTTTGCGAAGTAT
AGACACTGGAGCGATAAAAGACGAAAAGGACTCAATGAGGAACCGATTATCGCAGATGGTAAGCATGCGCCTATTATTGA
TAAAGCTTTATGGGATAAAGTACAGTTTAAACGCCAAGAGAGTCGCAAGAAACCACAAGTTCATGGTAAAGGGACCAATC
TACTTACTGGGATTGTAAAGTGCCCAAAATGTGGCGCAGCCATGGCGGCAAGTAATACGACCAATACATTAAAAGATGGC
ACTAAGAAAAGAATCAGATATTATTCATGTAGCAATTTTAGAAACAAAGGTTCTAAAGTATGTTCAGCCAATAGTGTTAG
AGCAGATGTATTAGAAAAATATGTTATGGACCAGATATTGGAAATTATCAAAAGTAAAAAGGTATTGAAGCAATTGGTTG
AAAAAGTAAATGAACAAAGCCAAATAGATAAATCTTCTTTGAATCATGATATTGCCTATAAACAGTCACAATGTGAAGAA
CTAAAAGCCAAAATGCATACATTAACGAAAACCATTGAAGACTCACCTGACTTAGATAGCGTATTGAAACCAACAATACT
TAACTATCAAGATGAATTGAATCAAATAAATAATCAAATCCATCAACTAGAGCAAGATAAACAAGCAGAAGCTCCACATT
ATGATGCTGATATGATTGCCAACGTACTACAAGCAATATTCAAAGATATAGACAAATTAGAGAAATCTCAGTTGAAATCA
CTCTATCTGACGGTTATCGATCGTATTGATATCCGAAACCATGAACATCATAAGAAGCAATTTTATGTTACGCTTAAACT
GAATAATGAAATTATCAAACAACTATTTAATAACCGTCCACTTGACGAAGTGCTCCTTAGCACTTCGTCTTTATTTTTGC
CACAAACTATATATATAACTATTGAATAA

Domains

Predicted by InterproScan.

Ogr/Delta-like zinc finger (Ogr_Delta)

(300-355)

Resolvase, N terminal domain (Resolvase)

(11-154)

Recombinase (Recombinase)

(179-280)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrB Staphylococcus aureus N315

72.14

100

0.721

Multiple sequence alignment